INT38095

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Context Info
Confidence 0.20
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
blood 2
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 28 99.88 Very High Very High Very High
chemokine 1 95.24 Very High Very High Very High
Potency 1 55.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.48 Very High Very High Very High
Necrosis 4 97.60 Very High Very High Very High
Adhesions 1 94.04 High High
Overdose 1 90.56 High High
Injury 6 87.76 High High
Hepatotoxicity 4 81.60 Quite High
Shock 2 81.16 Quite High
Ulcers 1 79.36 Quite High
Cancer 2 75.00 Quite High
Liver Failure 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(i.v.) 2 h prior to paracetamol, the increase in serum transaminase activity was reduced to 117 +/- 104 units/l and ethane exhalation amounted to 18 +/- 8 nmol kg-1 h-1.
Negative_regulation (reduced) of Positive_regulation (increase) of serum transaminase associated with paracetamol
1) Confidence 0.20 Published 1987 Journal Chem. Biol. Interact. Section Abstract Doc Link 3690721 Disease Relevance 0.08 Pain Relevance 0.39
On the contrary, serum transaminase elevation and histopathological changes were attenuated in TNF-Rp55-KO mice injected with APAP (600 mg/kg).
Negative_regulation (attenuated) of Positive_regulation (elevation) of serum transaminase associated with targeted disruption and paracetamol
2) Confidence 0.17 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.24 Pain Relevance 0.79
Treatment of mice with GGA 4h before or 0.5h after APAP administration suppressed increases in transaminase activities and ammonia content in blood as well as hepatic necrosis.
Negative_regulation (suppressed) of Positive_regulation (increases) of transaminase in blood associated with necrosis and paracetamol
3) Confidence 0.12 Published 2006 Journal Toxicology Section Abstract Doc Link 16377054 Disease Relevance 0.65 Pain Relevance 0.98

General Comments

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