INT38109

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.68
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CSN 3
membranous urethra 2
urethra 2
nerve trunk 1
meatus 1
Csn (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 13 99.96 Very High Very High Very High
Dopamine 6 96.72 Very High Very High Very High
anesthesia 5 92.08 High High
Catecholamine 1 84.80 Quite High
unmyelinated 12 65.92 Quite High
medulla 6 28.84 Quite Low
Spinal cord 78 11.16 Low Low
ketamine 13 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Incontinence 624 99.96 Very High Very High Very High
Hypoxia 7 99.12 Very High Very High Very High
Frailty 5 89.52 High High
Ganglion Cysts 2 79.92 Quite High
Injury 24 50.00 Quite Low
Overactive Bladder 48 20.08 Low Low
Peripheral Arterial Disease 12 18.80 Low Low
Spinal Cord Injury 72 11.52 Low Low
Urinary Dysfunction 12 7.68 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the translation of peripheral chemoreceptor activity into expiratory minute ventilation (VE) we used an index relating the increase of VE to the increase of CSN activity for a given hypoxic stimulus (delta VE/delta CSN).
Positive_regulation (increase) of CSN in CSN associated with hypoxia
1) Confidence 0.50 Published 1987 Journal J. Appl. Physiol. Section Abstract Doc Link 3693222 Disease Relevance 0.52 Pain Relevance 0.25
Relative stimulation thresholds were determined by inverting the AFs, and the simulation results suggest that the CSN is activated at lower thresholds by stimulation in the membranous urethra than the thresholds necessary to activate the DNP by stimulation in the penile urethra (Figure 3D).
Positive_regulation (activated) of CSN in membranous urethra associated with stress incontinence
2) Confidence 0.13 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.89 Pain Relevance 0
Following a 3-hour incubation of carotid bodies with their attached nerves in media containing 20 microM 3H-tyrosine, electrical stimulation of CSN C-fibers in chronically sympathectomized preparations provoked the release of 3H-DA, but not 3H-NE.
Positive_regulation (stimulation) of CSN in CSN associated with c fibre and dopamine
3) Confidence 0.11 Published 1993 Journal Biol. Signals Section Abstract Doc Link 8102579 Disease Relevance 0.08 Pain Relevance 0.40
The ability to activate the DNP selectively without co-activation of the CSN (and vice versa) was calculated for each electrode configuration at the different intraurethral locations (Figure 4).
Positive_regulation (activation) of CSN
4) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.80 Pain Relevance 0
The selectivity between activation of the DNP and the CSN was dependent on electrode geometry.
Positive_regulation (activation) of CSN
5) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.06 Pain Relevance 0
These results indicate that the DNP is more readily activated by stimulation in the penile urethra while the CSN is more readily activated by stimulation in the membranous urethra, which reflects the proximity of each nerve trunk to the corresponding segment of the urethra.
Positive_regulation (activated) of CSN in nerve trunk associated with stress incontinence
6) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.85 Pain Relevance 0
Further, these in vivo observations highlight the importance of selective DNP or CSN activation because the bladder response to activation of these nerves is different for different stimulation frequencies and involves different neural pathways [2].
Positive_regulation (activation) of CSN in neural
7) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.48 Pain Relevance 0
The DNP AFs (Figure 3A) were significantly greater in the penile urethra (1-4 cm) than in the membranous urethra (5-7 cm), while stimulation in the membranous urethra (5-7 cm) generated significantly greater CSN AFs (Figure 3B) than stimulation in the penile urethra (1-4 cm).
Positive_regulation (generated) of CSN in membranous urethra associated with stress incontinence
8) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.76 Pain Relevance 0
Selective activation of the DNP was best achieved by stimulation in the distal urethra (near the glans) while selective activation of the CSN was best achieved by stimulation in the proximal urethra (near the prostate).
Positive_regulation (activation) of CSN in urethra associated with stress incontinence
9) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.35 Pain Relevance 0
No electrode geometry exhibited selectivity >1 at 4 cm from the urethral meatus, suggesting that stimulation in the penile bulb will produce co-activation of the CSN and DNP.
Positive_regulation (activation) of CSN in meatus
10) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.05 Pain Relevance 0
This reveals that at ~4 cm (the proximal portion of the penile bulb) neither the DNP nor the CSN can be activated selectively.
Positive_regulation (activated) of CSN in bulb
11) Confidence 0.08 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.40 Pain Relevance 0
The simulation and in vivo results show that the threshold for pudendal afferent fiber activation for stimulation in the proximal urethra (CSN activation) was lower than the threshold for stimulation in the penile urethra (DNP activation), so future clinical studies should investigate the use of lower amplitude stimuli in the proximal urethra compared to the penile urethra to avoid spillover of activation to neighboring nerves (e.g., autonomic innervation of the proximal urethra).
Positive_regulation (activation) of CSN in urethra associated with stress incontinence
12) Confidence 0.07 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.86 Pain Relevance 0.10
Additionally, selective activation of the DNP or CSN depends on stimulation location.
Positive_regulation (activation) of CSN
13) Confidence 0.07 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.23 Pain Relevance 0
The results of this study show that the location and geometry of the electrode both play significant roles in determining the stimulation threshold and selective activation of the two primary sensory branches (DNP, CSN) of the cat pudendal nerve.
Positive_regulation (activation) of CSN in nerve
14) Confidence 0.07 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.25 Pain Relevance 0
In unlesioned rats, Fast Blue traced CSN from similar coronal levels as for the lentivector transduced rats were analyzed.
Positive_regulation (traced) of CSN
15) Confidence 0.04 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0

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