INT38130

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.16
Pain Relevance 7.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 2
spinal cord 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 104 100.00 Very High Very High Very High
Periaqueductal grey 55 100.00 Very High Very High Very High
agonist 31 100.00 Very High Very High Very High
antinociception 23 99.96 Very High Very High Very High
tetrodotoxin 2 99.84 Very High Very High Very High
Morphine 77 99.66 Very High Very High Very High
Spinal cord 12 99.60 Very High Very High Very High
Antinociceptive 18 99.28 Very High Very High Very High
Neuropathic pain 9 99.08 Very High Very High Very High
antagonist 25 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 190 100.00 Very High Very High Very High
Injury 17 99.72 Very High Very High Very High
Neuropathic Pain 13 99.08 Very High Very High Very High
Pain 48 97.28 Very High Very High Very High
Inflammatory Pain 13 94.40 High High
INFLAMMATION 22 87.60 High High
Stress 8 85.28 High High
Nociception 29 66.08 Quite High
Targeted Disruption 1 64.76 Quite High
Hyperalgesia 10 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M), local electrical stimulation evoked IPSCs in PAG neurons which were abolished by tetrodotoxin (300 nM, n = 3) and by the GABAA antagonist SR95531 (10 ?
Negative_regulation (abolished) of Gene_expression (neurons) of PAG in neurons associated with tetrodotoxin, antagonist and periaqueductal grey
1) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.25 Pain Relevance 0.41
However, no significant alteration was detected in the NR2A expression in the PAG after injury (Fig. 1).
Negative_regulation (detected) of Gene_expression (expression) of PAG associated with injury and central grey
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.72 Pain Relevance 0.96
produced by microinjection of DOR agonists into the PAG is weak compared to
Negative_regulation (microinjection) of Gene_expression (produced) of PAG associated with agonist and urological neuroanatomy
3) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.65 Pain Relevance 1.59
PAG/NRD stimulation-produced inhibition of the VIR was completely eliminated by bilateral section of the dorsolateral funiculi.
Negative_regulation (inhibition) of Gene_expression (produced) of PAG associated with central grey
4) Confidence 0.19 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697757 Disease Relevance 0.94 Pain Relevance 0.62
Pretreatment with AS-ODN against PP 2 A or PP5 via each route weakened the antinociceptive effect of morphine, accompanied by reduction of expression levels of PP in the periaqueductal gray (PAG) and the spinal cord.
Negative_regulation (reduction) of Gene_expression (expression) of PAG in spinal cord associated with central grey, antinociceptive, spinal cord and morphine
5) Confidence 0.16 Published 2005 Journal Brain Res. Section Abstract Doc Link 16102737 Disease Relevance 0.29 Pain Relevance 1.45
Urinary profiles of HBF mice showed lower levels of PAG, tryptamine and an unknown metabolite (U1), and higher levels of ?
Negative_regulation (showed) of Gene_expression (levels) of PAG associated with urological neuroanatomy
6) Confidence 0.12 Published 2007 Journal Mol Syst Biol Section Body Doc Link PMC2673711 Disease Relevance 0.16 Pain Relevance 0.12
Conversely, the down-regulated P2X3 receptor expression in the lPAG with antisense oligodeoxynucleotide (ODN) for P2X3 gene significantly attenuated the antinociceptive effect of EA treatment.
Negative_regulation (down-regulated) of Gene_expression (expression) of lPAG associated with electroacupuncture and antinociceptive
7) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.17 Pain Relevance 1.54
These results suggest that P2X3 receptors in the lPAG play an inhibitory role in pain modulation and EA exerts a marked therapeutic effect in relieving neuropathic pain in CCI rats, which may be related to its regulative effect on the expression of P2X3 receptors in the lPAG.
Negative_regulation (effect) of Gene_expression (expression) of lPAG associated with pain, neuropathic pain and electroacupuncture
8) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 0.99 Pain Relevance 1.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox