INT38153

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Context Info
Confidence 0.31
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.31
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vps54) growth (Vps54)
Anatomy Link Frequency
liver 1
muscle fibers 1
Vps54 (Mus musculus)
Pain Link Frequency Relevance Heat
halothane 6 99.84 Very High Very High Very High
alcohol 6 96.88 Very High Very High Very High
lidocaine 1 96.40 Very High Very High Very High
cytokine 22 88.84 High High
Inflammation 46 79.84 Quite High
palliative 2 63.28 Quite High
positron emission tomography 74 62.88 Quite High
imagery 38 9.36 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 319 100.00 Very High Very High Very High
Contracture 11 100.00 Very High Very High Very High
Metastasis 42 99.76 Very High Very High Very High
Viral Infection 1 99.76 Very High Very High Very High
Hepatitis 19 98.76 Very High Very High Very High
Colon Cancer 2 98.16 Very High Very High Very High
Malignant Neoplastic Disease 14 97.84 Very High Very High Very High
Apoptosis 48 94.48 High High
Hyperplasia 16 93.92 High High
Cancer 283 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is proposed that the HCC results from synergistic interaction of halothane and low temperature inhibiting Ca-sequestration by the sarcoplasmic reticulum of the muscle fibers.
HCC Binding (interaction) of in muscle fibers associated with contracture and halothane
1) Confidence 0.31 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3701644 Disease Relevance 0.79 Pain Relevance 0.27
Our immunohistochemistry staining of VEGF showed that only the vehicle control mice eventually developed advanced HCC characterized by poorly differentiated HCC tissues surrounded by well-differentiated HCC tissues.
HCC Binding (characterized) of associated with hepatocellular cancer
2) Confidence 0.04 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.32 Pain Relevance 0.03
However, its effect in HCC is less conclusively documented.
HCC Binding (effect) of associated with hepatocellular cancer
3) Confidence 0.04 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.87 Pain Relevance 0.06
To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC.


HCC Binding (associated) of associated with hepatocellular cancer and metastasis
4) Confidence 0.03 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2845108 Disease Relevance 0.73 Pain Relevance 0
Studies with genetically modified mice have revealed many genes associated with HCC.
HCC Binding (associated) of associated with hepatocellular cancer
5) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.60 Pain Relevance 0.04
These observations suggest that a better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.



HCC Binding (target) of in liver associated with hepatocellular cancer
6) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.56 Pain Relevance 0.11
HCC has been strongly associated with viral infections such as hepatitis B and C; exposure to toxins, such as alcohol, aflatoxin, and phenobarbital; and exposure to various carcinogens such as polyvinyl chloride (Thorgeirsson and Grisham 2002).
HCC Binding (associated) of associated with viral infection, hepatocellular cancer, hepatitis and alcohol
7) Confidence 0.01 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.44 Pain Relevance 0.05

General Comments

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