INT38154

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 7.99
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vps54) growth (Vps54)
Vps54 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 173 97.60 Very High Very High Very High
lidocaine 2 96.40 Very High Very High Very High
cytokine 21 92.84 High High
imagery 19 90.36 High High
positron emission tomography 37 88.32 High High
halothane 12 86.44 High High
Inflammation 46 62.48 Quite High
metalloproteinase 38 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 402 100.00 Very High Very High Very High
Contracture 22 100.00 Very High Very High Very High
Cancer 280 99.96 Very High Very High Very High
Metastasis 104 99.52 Very High Very High Very High
Targeted Disruption 26 99.42 Very High Very High Very High
Residual Neoplasm 12 94.28 High High
Death 20 82.44 Quite High
Lifespan 32 63.08 Quite High
INFLAMMATION 46 62.48 Quite High
Severe Combined Immunodeficiency 1 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither membrane depolarization with high [K]0 solutions nor a short (2 min) exposure to Ca-free media inhibits the HCC.
Negative_regulation (inhibits) of HCC associated with contracture
1) Confidence 0.37 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3701644 Disease Relevance 0.88 Pain Relevance 0.28
The HCC is abolished by 4 mM procaine, partially inhibited by 4 to 10 mM procainamide and potentiated by 4 mM lidocaine, but it is not significantly affected by dantrolene (40 microM).
Negative_regulation (abolished) of HCC associated with contracture and lidocaine
2) Confidence 0.37 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3701644 Disease Relevance 0.85 Pain Relevance 0.30
To assess whether the combined suppression of both VEGF activity by bevacizumab and VEGF expression by targeting mTOR via rapamycin (RAPA) results in the inhibition of HCC tumor, we created an orthotopic xenograft HCC model.
Spec (whether) Negative_regulation (inhibition) of HCC associated with cancer and hepatocellular cancer
3) Confidence 0.05 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.15 Pain Relevance 0.37
China) inhibits HCC, which may be attributable to anti-angiogenesis [14,16].


Negative_regulation (inhibits) of HCC associated with hepatocellular cancer
4) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.61 Pain Relevance 0.13
to inhibit HCC.
Negative_regulation (inhibit) of HCC associated with hepatocellular cancer
5) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.67 Pain Relevance 0.11
The compound was diluted with distilled water for further use, which inhibits HCC cell lines MHCC97H with high invasive potential and Hep3B cells with very low invasiveness in vitro and inhibits HCC growth and metastasis in vivo [15].
Negative_regulation (inhibits) of HCC associated with hepatocellular cancer and metastasis
6) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.59 Pain Relevance 0.07
The higher ratio of MMP/TIMP has been related to a poorer prognosis in HCC [26].
Negative_regulation (prognosis) of HCC associated with hepatocellular cancer
7) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.03 Pain Relevance 0.58
In fact, DEN-induced hepatocarcinogenesis has been examined in IL-6 knockout mice and wild-type controls, and a marked reduction in HCC incidence was seen in IL-6 knockout mice.
Negative_regulation (reduction) of HCC associated with targeted disruption and hepatocellular cancer
8) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.11 Pain Relevance 0.07
knockout mice, and the occurrence of HCC was reduced.
Negative_regulation (reduced) of HCC associated with targeted disruption and hepatocellular cancer
9) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.09 Pain Relevance 0.08

General Comments

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