INT3816

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Context Info
Confidence 0.65
First Reported 1977
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.51
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
blood 1
Ahr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
agonist 23 99.20 Very High Very High Very High
aspirin 2 98.80 Very High Very High Very High
Pain 3 97.56 Very High Very High Very High
bradykinin 1 96.60 Very High Very High Very High
Inflammation 40 96.20 Very High Very High Very High
cINOD 2 95.44 Very High Very High Very High
Analgesic 2 87.40 High High
Arthritis 2 85.68 High High
corticosteroid 18 84.24 Quite High
Disease Link Frequency Relevance Heat
Asthma 259 99.30 Very High Very High Very High
Cough 34 98.76 Very High Very High Very High
Sickle Cell Anemia 9 98.16 Very High Very High Very High
Acute Chest Syndrome 3 97.84 Very High Very High Very High
Nociception 1 97.76 Very High Very High Very High
Pain 3 97.56 Very High Very High Very High
Occupational Lung Diseases 12 96.84 Very High Very High Very High
Respiratory Syncytial Virus 116 96.32 Very High Very High Very High
INFLAMMATION 42 96.20 Very High Very High Very High
Stress 15 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Gene_expression (include) of AHR
1) Confidence 0.65 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Gene_expression (/) of AHR
2) Confidence 0.65 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0
Single-dose studies showed that AHR-5850 produced less gastric irritation than acetylsalicylic acid when applied topically to the exposed gastric mucosa of cats or when administered orally to rats and dogs.
Gene_expression (produced) of AHR-5850 associated with aspirin
3) Confidence 0.62 Published 1977 Journal Agents Actions Section Abstract Doc Link 871089 Disease Relevance 0.57 Pain Relevance 0.61
Evaluation of AHR with methacholine challenge in patients with SCD appears to be well tolerated and may elucidate a cause of SCD morbidity.
Gene_expression (Evaluation) of AHR associated with sickle cell anemia
4) Confidence 0.43 Published 2008 Journal Pediatr. Pulmonol. Section Abstract Doc Link 18671275 Disease Relevance 1.01 Pain Relevance 0.19
A number of xenobiotic metabolism related receptors of interest were present on the array but were either not differentially expressed (pregnane X receptor, Nr1i2; constitutive androstane receptor, Nr1i3; aryl hydrocarbon receptor, Ahr; peroxisome proliferator-activated receptor alpha and gamma, Ppara/Pparg; retinoid x receptor alpha and beta, Rxra/Rxrb) or minimally passed threshold criteria for differential expression (retinoid X receptor, Rxrg).
Neg (not) Gene_expression (expressed) of hydrocarbon receptor
5) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
A number of xenobiotic metabolism related receptors of interest were present on the array but were either not differentially expressed (pregnane X receptor, Nr1i2; constitutive androstane receptor, Nr1i3; aryl hydrocarbon receptor, Ahr; peroxisome proliferator-activated receptor alpha and gamma, Ppara/Pparg; retinoid x receptor alpha and beta, Rxra/Rxrb) or minimally passed threshold criteria for differential expression (retinoid X receptor, Rxrg).
Neg (not) Gene_expression (expressed) of Ahr
6) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
From the latter analysis, the authors obtained the blood effect-site equilibration half-life (t1/2ke0) and the effect-site concentration producing 25% depression of Vi45 and AHR (C25).
Gene_expression (producing) of AHR in blood
7) Confidence 0.32 Published 2003 Journal Anesthesiology Section Body Doc Link 14508308 Disease Relevance 0.06 Pain Relevance 0
Twelve subjects with asymptomatic AHR had a provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20) of ?
Gene_expression (subjects) of AHR
8) Confidence 0.30 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 1.60 Pain Relevance 0
No significant differences were observed between the atopic asymptomatic AHR group and mild atopic asthma group in terms of mean RBM thicknesses (p>0.05, Fig. 1), nor between the non-atopic asymptomatic AHR group and the two control groups in terms of mean RBM thicknesses (p>0.05, Fig. 1).


Gene_expression (group) of AHR associated with asthma
9) Confidence 0.30 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 0.32 Pain Relevance 0
Mean RBM thicknesses were significantly higher in the mild atopic asthma group and the atopic asymptomatic AHR group than in the other three groups (p=0.048, Fig. 1, 2), which is also in minimum RBM thicknesses (p=0.037).
Gene_expression (group) of AHR associated with asthma
10) Confidence 0.30 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 0.37 Pain Relevance 0
We conclude that AHR or increased CRS is present during the coughing phase in children with recurrent cough.
Gene_expression (present) of AHR associated with cough
11) Confidence 0.28 Published 1997 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 9196099 Disease Relevance 1.43 Pain Relevance 0.13
Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro.
Gene_expression (expression) of aryl hydrocarbon receptor
12) Confidence 0.26 Published 2006 Journal Carcinogenesis Section Title Doc Link 16531450 Disease Relevance 0.17 Pain Relevance 0.14
Indeed, PDM02 and PDM11 are AhR antagonists, while PDM10 is an agonist (TableĀ 1); but they all displayed the same inhibitory effect toward OC differentiation, and furthermore, RSV always showed inhibitory activity ([10] and present results), in contrast with the situation of Voronov et al. [42], where it was tested in the presence of AhR agonists and stimulated resorption.
Gene_expression (antagonists) of AhR associated with antagonist, agonist and respiratory syncytial virus
13) Confidence 0.26 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.73 Pain Relevance 0.14
EIB is considered a form of airway hyperresponsiveness (AHR) and its expression increases and decreases in relationship to the degree of underlying airway reactivity9 and the severity of the underlying asthma.10 The importance of AHR in EIB and asthma was emphasized by a recent study which showed that children with increased airway responsiveness in late infancy and childhood had a greater risk of developing asthma than their counterparts who did not have increased airway responsiveness in infancy.11
Gene_expression (expression) of AHR associated with asthma
14) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 0.99 Pain Relevance 0.09

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