INT3817

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 22.12
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
colon 2
macrophages 1
dendritic cells 1
thymus 1
hearts 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 99.52 Very High Very High Very High
cINOD 179 99.20 Very High Very High Very High
aspirin 28 98.90 Very High Very High Very High
metalloproteinase 9 94.88 High High
isoflurane 4 93.96 High High
withdrawal 2 92.48 High High
Inflammatory response 15 92.00 High High
Enkephalin 1 91.28 High High
agonist 58 90.56 High High
COX-2 inhibitor 30 88.48 High High
Disease Link Frequency Relevance Heat
Cancer 798 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 494 100.00 Very High Very High Very High
Adenoma 143 100.00 Very High Very High Very High
Polyps 154 99.98 Very High Very High Very High
Intestinal Cancer 12 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 141 99.82 Very High Very High Very High
Disease 255 99.80 Very High Very High Very High
Targeted Disruption 67 99.76 Very High Very High Very High
Aging 21 99.76 Very High Very High Very High
Pancreatitis 11 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention.
Negative_regulation (loss) of Apc associated with aspirin, inflammation, cancer and cinod
1) Confidence 0.58 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11585736 Disease Relevance 0.58 Pain Relevance 0.41
Generally, colon cancers show either chromosomal instability (CIN), which correlates with loss of APC function, or microsatellite instability, which correlates with loss of mismatch repair function, but not both.
Negative_regulation (loss) of APC in colon associated with chromosomal instability, familial adenomatous polyposis, colon cancer and microsatellite instability
2) Confidence 0.51 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.97 Pain Relevance 0
The EP receptor subtype EP1 mediates the effects of PGE(2) by increasing intracellular calcium levels ([Ca(2+)](i)), whereas antagonism of EP1 has been shown to attenuate tumorigenesis in Apc(Min/+) mice.
Negative_regulation (attenuate) of Apc
3) Confidence 0.43 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11809688 Disease Relevance 0.78 Pain Relevance 0.31
Sulindac chemoprotection activity although potent in Gdf15 ( +/+ ), Apc ( min/+ ) mice was abolished in Gdf15 ( -/- ), Apc ( min/+ ) mice.
Negative_regulation (abolished) of Apc
4) Confidence 0.43 Published 2010 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 19784846 Disease Relevance 0.16 Pain Relevance 0
Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.
Negative_regulation (Chemoprevention) of Min associated with adenoma, inflammation and cinod
5) Confidence 0.41 Published 1996 Journal Cancer Res. Section Title Doc Link 8631000 Disease Relevance 0.59 Pain Relevance 0.17
Hematocrit values in untreated Min/+ mice were drastically reduced compared with those in wild-type C57Bl/6J mice.
Negative_regulation (reduced) of Min
6) Confidence 0.41 Published 2002 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12050094 Disease Relevance 0.39 Pain Relevance 0.06
Finally, whole-genome allelic loss studies showed that there were few unique chromosomal deletions in the NSAID-resistant tumors from F1 mice, implying that loss-of-function mutations secondary to Apc inactivation are not likely to account for the observed difference in chemoresistance.
Negative_regulation (inactivation) of Apc associated with cancer and cinod
7) Confidence 0.41 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 9934849 Disease Relevance 0.83 Pain Relevance 0.19
Indomethacin, 1.5 mg/kg iv, or acetylsalicylic acid, 150 mg/kg given intragastrically, altered propagation velocity and at times its direction of propagation, but did not abolish the MAPC.
Neg (not) Negative_regulation (abolish) of MAPC associated with aspirin
8) Confidence 0.38 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 871161 Disease Relevance 0.75 Pain Relevance 0.30
Indomethacin, 5.0 mg/kg iv, abolished all MAPC activity.
Negative_regulation (abolished) of MAPC
9) Confidence 0.38 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 871161 Disease Relevance 0.77 Pain Relevance 0.32
Apc(min)/+ progeny of pregnant dams treated with piroxicam and/or DFMO were reduced in number and their ratio to Apc+/+ progeny was decreased to approximately 0.28:1.
Negative_regulation (reduced) of Apc
10) Confidence 0.37 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10766173 Disease Relevance 0.71 Pain Relevance 0
When a specific APC mutation has been identified in an index patient all 1st degree relatives carry a 50% risk of FAP and should be referred for genetic counseling and offered APC mutation testing.
Negative_regulation (referred) of APC associated with familial adenomatous polyposis
11) Confidence 0.32 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.75 Pain Relevance 0.11
to suppress tumor growth is also through inhibiting APC/?
Negative_regulation (inhibiting) of APC associated with cancer
12) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.44 Pain Relevance 0.20
The two genes, Apc and Siah1, which were found to be downregulated in Dll1 mutants, are known to act via ?
Negative_regulation (downregulated) of Apc
13) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.29 Pain Relevance 0
Consistently, the BrdU labelling index also decreased in Apc?
Negative_regulation (decreased) of Apc
14) Confidence 0.25 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.06 Pain Relevance 0
Requirement of macrophages for intestinal tumour development in Apc?
Negative_regulation (development) of Apc in macrophages associated with intestinal cancer
15) Confidence 0.25 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.26 Pain Relevance 0.05
This effect occurred despite loss of Apc heterozygosity and beta-catenin activation.
Negative_regulation (loss) of Apc
16) Confidence 0.24 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.86 Pain Relevance 0.07
on a C57BL/6 genetic background is about 50, while the polyp number in ApcMin/+
Negative_regulation (number) of ApcMin associated with polyps
17) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 0.89 Pain Relevance 0
ligands have a negative effect on the APC functions of dendritic cells [69].
Negative_regulation (effect) of APC in dendritic cells
18) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.35 Pain Relevance 0.11
HDL augment APC-induced inactivation of Va and VIIIa factors (Griffin et al 1999).
Negative_regulation (inactivation) of APC-induced associated with disorder of lipid metabolism
19) Confidence 0.12 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.14 Pain Relevance 0
However, COX-1-deficient Min mice exhibit similar decreases in intestinal tumorigenesis as COX-2-null Min mice [12].
Negative_regulation (decreases) of Min
20) Confidence 0.12 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.99 Pain Relevance 0.33

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