INT38173

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 40
Total Number 45
Disease Relevance 32.63
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
plasma 3
liver 3
brain 3
Epithelium 2
fibroblasts 2
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 176 100.00 Very High Very High Very High
antinociception 1 99.96 Very High Very High Very High
Chronic pancreatitis 80 99.84 Very High Very High Very High
antagonist 65 99.04 Very High Very High Very High
ischemia 34 99.04 Very High Very High Very High
Central nervous system 1 98.60 Very High Very High Very High
Inflammation 239 98.32 Very High Very High Very High
Antinociceptive 3 97.28 Very High Very High Very High
Inflammatory mediators 7 96.64 Very High Very High Very High
Pain 10 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 31 99.88 Very High Very High Very High
Cancer 927 99.84 Very High Very High Very High
Pancreatitis 80 99.84 Very High Very High Very High
Pancreatic Cancer 140 99.80 Very High Very High Very High
Aggression 8 99.70 Very High Very High Very High
Metastasis 564 99.56 Very High Very High Very High
Colon Cancer 574 99.34 Very High Very High Very High
Cv Unclassified Under Development 124 99.04 Very High Very High Very High
Renal Disease 151 98.76 Very High Very High Very High
INFLAMMATION 249 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously demonstrated the increased expression of angiogenin (ANG) in pancreatic cancer and its relation to cancer aggressiveness; however, the expression patterns and the roles of angiogenin in chronic pancreatitis are still unknown.
Gene_expression (expression) of angiogenin associated with cancer, aggression, pancreatic cancer and chronic pancreatitis
1) Confidence 0.75 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 0.83 Pain Relevance 0.46
Increased angiogenin expression in obstructive chronic pancreatitis surrounding pancreatic cancer but not in pure chronic pancreatitis.
Gene_expression (expression) of angiogenin associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.75 Published 1999 Journal Pancreas Section Title Doc Link 10206479 Disease Relevance 1.08 Pain Relevance 0.65
These findings suggest that ANG expression is increased in pancreatic cancer surrounding tissue but is not increased in pure chronic pancreatitis, and that ANG is potentially involved in the pancreatic cancer microenvironment rather than the establishment of pure chronic pancreatitis.
Gene_expression (expression) of ANG associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.75 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.46 Pain Relevance 0.75
We previously demonstrated the increased expression of angiogenin (ANG) in pancreatic cancer and its relation to cancer aggressiveness; however, the expression patterns and the roles of angiogenin in chronic pancreatitis are still unknown.
Gene_expression (expression) of ANG associated with cancer, aggression, pancreatic cancer and chronic pancreatitis
4) Confidence 0.75 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 0.83 Pain Relevance 0.46
First suggestions that the Mas gene codes for an Ang II-sensitive receptor [12] have been corrected by findings that alterations in intracellular Ca2+-concentrations in Mas-transfected cells after Ang II treatment could only be confirmed in cells expressing the Ang II receptor AT1 endogenously [13], [14].
Gene_expression (expressing) of Ang
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.64 Pain Relevance 0.26
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Gene_expression (production) of Ang in kidney associated with renal disease
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.17
We previously demonstrated the increased expression of angiogenin (ANG) in pancreatic cancer and its relation to cancer aggressiveness; however, the expression patterns and the roles of angiogenin in chronic pancreatitis are still unknown.
Gene_expression (expression) of angiogenin associated with cancer, aggression, pancreatic cancer and chronic pancreatitis
7) Confidence 0.65 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 0.93 Pain Relevance 0.56
By contrast, acinar cells and interstitial fibroblasts in the tissues surrounding pancreatic cancer showed increased ANG mRNA expression.
Gene_expression (expression) of ANG in acinar cells associated with pancreatic cancer
8) Confidence 0.65 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.32 Pain Relevance 0.76
Our results suggest that ANG produces antinociception via acting on the central nervous system and shows antinociceptive profiles in various pain models, especially inflammatory pain.
Gene_expression (produces) of ANG in central nervous system associated with pain, antinociception, ipn, central nervous system and antinociceptive
9) Confidence 0.59 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951472 Disease Relevance 0.51 Pain Relevance 0.71
Our data implicates that the proinflammatory properties of Ang-(1–7) and the Mas receptor in the kidney are primarily stimulated by a local activation of the NF-?
Gene_expression (receptor) of Ang in kidney
10) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.60 Pain Relevance 0.40
The pro-angiogenic effects of ANG II are mediated by the ANG II type 1 receptor (AT1R), which is overexpressed in several human cancers [7-19].
Gene_expression (overexpressed) of ANG associated with cancer
11) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.23 Pain Relevance 0
The significant reduction in ACE expression at day 16 following captopril treatment suggests that in addition to the inhibition of ACE activity, captopril also reduces ACE levels, presumably leading to an even greater inhibition of ANG II production.
Gene_expression (production) of ANG
12) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.05 Pain Relevance 0
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Gene_expression (production) of Ang in plasma
13) Confidence 0.51 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.19 Pain Relevance 0.11
We investigated the expression of ANG both in the tissues and in the sera of chronic pancreatitis patients (pure chronic pancreatitis) by using in situ hybridization, Western blot analysis, and enzyme-linked immunosorbent assay.
Spec (investigated) Gene_expression (expression) of ANG associated with chronic pancreatitis
14) Confidence 0.51 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.00 Pain Relevance 0.64
In situ hybridization revealed no detectable ANG messenger RNA (mRNA) signals in all tissues of pure chronic pancreatitis and normal pancreas.
Neg (no) Gene_expression (detectable) of ANG in pancreas associated with chronic pancreatitis
15) Confidence 0.51 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.07 Pain Relevance 0.68
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Gene_expression (expression) of ANG in liver associated with cancer, colon cancer and metastasis
16) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.75 Pain Relevance 0
Since the contribution of MSFs to cell proliferation is approximately one third of the total cell proliferation (MSF + PAN02), since MSF cell proliferation was not influenced by the status of AT2 receptor expression (Figure 5) nor by the presence of Ang II or the AT2 antagonist (data not shown), and since PAN02 cells do not express Ang II receptors, the growth of PAN02 cells appears to be indirectly regulated by the MSFs.
Neg (not) Gene_expression (express) of Ang associated with antagonist
17) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.30 Pain Relevance 0.05
Thus, in the captopril treated liver, the production of ANG II would be severely compromised by the inhibition of its conversion from ANG I, the preferential production of ANG-(1-7), and the reduction of angiotensinogen expression, all of which would contribute to the reduced availability of ANG II to support tumor growth [43,44].


Gene_expression (production) of ANG in liver associated with cancer
18) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.88 Pain Relevance 0
We show a marked up-regulation of ACE during CRC metastases development, which would presumably favor CRC metastases growth by increasing production of ANG II.
Gene_expression (production) of ANG associated with colon cancer and metastasis
19) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.39 Pain Relevance 0
ACE-2 generates the biologically active peptide, Ang (1–7), from Ang II and the inactive peptide Ang (1–9) from Ang I [17, 18].
Gene_expression (generates) of Ang
20) Confidence 0.40 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.39 Pain Relevance 0

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