INT3818

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Context Info
Confidence 0.39
First Reported 1977
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 12.52
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
CD86 1
plasma 1
blood 1
epithelium 1
saliva 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 14 100.00 Very High Very High Very High
Inflammation 93 96.40 Very High Very High Very High
cytokine 102 93.08 High High
aspirin 3 92.80 High High
Action potential 2 91.68 High High
Central nervous system 30 90.08 High High
agonist 35 75.28 Quite High
addiction 4 13.80 Low Low
chemokine 12 9.64 Low Low
Pain 5 6.08 Low Low
Disease Link Frequency Relevance Heat
Cancer 592 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 487 100.00 Very High Very High Very High
INFLAMMATION 113 100.00 Very High Very High Very High
Aging 106 99.28 Very High Very High Very High
Diarrhoea 6 99.28 Very High Very High Very High
Adenoma 121 99.14 Very High Very High Very High
Endotoxemia 5 99.08 Very High Very High Very High
Disorder Of Lipid Metabolism 141 99.00 Very High Very High Very High
Vibrio Infection 7 98.92 Very High Very High Very High
Repression 2 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous APC truncation has been shown to affect chromosome attachment in cultured cells.
Regulation (affect) of APC associated with familial adenomatous polyposis
1) Confidence 0.39 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.18 Pain Relevance 0
We investigated effects of these anti-inflammatory drugs on the MAPC.
Spec (investigated) Regulation (effects) of MAPC associated with inflammation and cinod
2) Confidence 0.24 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 871161 Disease Relevance 0.78 Pain Relevance 0.33
The mouse model of FAP contains a point mutation in the APC gene; it develops numerous adenomas and was the first model used to study the involvement of the APC gene in intestinal tumorigenesis.
Regulation (involvement) of APC gene associated with adenoma and familial adenomatous polyposis
3) Confidence 0.23 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.69 Pain Relevance 0
Of course, other modulations of APC8015 therapy might also be investigated, including increased number of infusions, coordination with standard hormonal therapies, or combination with standard radiation or even chemotherapies.
Regulation (modulations) of APC8015
4) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503669 Disease Relevance 0.36 Pain Relevance 0.05
A number of protein factors have been identified that regulate APC in both a positive and negative manner.
Regulation (regulate) of APC
5) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503669 Disease Relevance 0.14 Pain Relevance 0
HDL may affect the blood coagulation process via the regulation of activated protein C (APC), which is the crucial element regulating blood coagulation by the proteolytic inactivation of Va and VIIIa factors.
Regulation (regulation) of APC in blood associated with disorder of lipid metabolism
6) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.22 Pain Relevance 0
transcriptional target of APC/?
Regulation (target) of APC
7) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.40 Pain Relevance 0.25
, we then examined the role of CD40 ligation in APC function of A?
Spec (examined) Regulation (role) of APC
8) Confidence 0.13 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.35 Pain Relevance 0.34
(e) Recently, we reported that Wnt-7a induces dissociation of the APC protein from the ?
Regulation (dissociation) of APC
9) Confidence 0.12 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.71 Pain Relevance 0.13
Probably the numbers of major histocompatibility complex (MHC)-II, CD80, and CD86 co-receptors on APC do not change appreciably with aging, according to most available data.
Neg (not) Regulation (change) of APC in CD86 associated with aging
10) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.57 Pain Relevance 0.07
These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin.
Regulation (modulate) of APC associated with familial adenomatous polyposis
11) Confidence 0.06 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16382042 Disease Relevance 0.54 Pain Relevance 0.06
On the other hand, the MIN-O sizes were not statistically different between the two SERM groups.
Neg (not) Regulation (different) of MIN-O associated with cancer
12) Confidence 0.06 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.59 Pain Relevance 0
The SERM treatment did not affect the intensity of the cytoplasmic PyV-mT staining in the MIN-O epithelium (Fig. 2e).
Regulation (intensity) of MIN-O in epithelium associated with cancer
13) Confidence 0.06 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.02 Pain Relevance 0
The mechanisms by which tick saliva alters antigen presenting cell (APC) function are poorly understood.
Regulation (alters) of APC in saliva
14) Confidence 0.02 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.14 Pain Relevance 0.09
In an porcine model of endotoxemia, Nielsen et al. confirmed a pro-fibrinolytic effect of aPC by decreasing plasma levels of plasminogen activator inhibitor 1 [17].
Regulation (effect) of aPC in plasma associated with endotoxemia
15) Confidence 0.01 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.85 Pain Relevance 0.37

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