INT38189

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.68
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Svs4) extracellular region (Svs4)
Anatomy Link Frequency
brain 1
Svs4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 28 100.00 Very High Very High Very High
tetrodotoxin 6 99.88 Very High Very High Very High
anesthesia 14 98.32 Very High Very High Very High
halothane 12 98.10 Very High Very High Very High
analgesia 2 97.28 Very High Very High Very High
antagonist 22 97.20 Very High Very High Very High
isoflurane 8 92.56 High High
Antinociceptive 8 91.72 High High
tail-flick 4 89.36 High High
antiallodynic 2 77.68 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 15 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.88 Very High Very High Very High
Hypercapnia 2 94.40 High High
Nociception 38 93.80 High High
Bordatella Infection 5 87.08 High High
Ganglion Cysts 154 73.68 Quite High
Neuropathic Pain 11 73.28 Quite High
Pain 42 50.00 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Qualitatively different responses of ADP levels have previously been observed in the brain during hypercarbia.
Regulation (responses) of ADP in brain
1) Confidence 0.24 Published 1986 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3711164 Disease Relevance 0 Pain Relevance 0.34
Hypercarbia during halothane anesthesia caused the measured phosphocreatine (PCr) to decrease by 40%, while the calculated change in ADP was 10%, in agreement with the former investigation.
Regulation (change) of ADP associated with anesthesia and halothane
2) Confidence 0.24 Published 1986 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3711164 Disease Relevance 0 Pain Relevance 1.01
After TTX, the ADP and ADO responses were normal, but NMDA and hypoxia responses were completely blocked.
Regulation (responses) of ADP associated with tetrodotoxin, adenocard and hypoxia
3) Confidence 0.06 Published 1995 Journal Brain Res. Section Abstract Doc Link 8750962 Disease Relevance 1.20 Pain Relevance 0.63
It efficiently inhibits P2X receptors, but it discriminates between ADP and UTP responses on P2Y receptors.
Regulation (responses) of ADP
4) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.09 Pain Relevance 0.11
In addition to the pyrimidine nucleotides acting on P2Y2, P2Y4, and P2Y6 receptors, the ADP analog ADP-?
Regulation (acting) of ADP
5) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.70 Pain Relevance 0.63
In addition to the pyrimidine nucleotides acting on P2Y2, P2Y4, and P2Y6 receptors, the ADP analog ADP-?
Regulation (acting) of ADP
6) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.70 Pain Relevance 0.63

General Comments

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