INT3819

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 27.03
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
colon 2
macrophages 1
myocardium 1
lymph node 1
epithelium 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 57 100.00 Very High Very High Very High
cytokine 124 99.68 Very High Very High Very High
Inflammation 414 99.48 Very High Very High Very High
cINOD 65 99.16 Very High Very High Very High
Action potential 5 96.96 Very High Very High Very High
tolerance 33 96.60 Very High Very High Very High
Nicotine 7 96.40 Very High Very High Very High
rheumatoid arthritis 170 95.60 Very High Very High Very High
COX-2 inhibitor 7 94.64 High High
Morphine 2 94.64 High High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 778 100.00 Very High Very High Very High
Cancer 487 100.00 Very High Very High Very High
Adenoma 182 100.00 Very High Very High Very High
Intestinal Cancer 16 100.00 Very High Very High Very High
Cv General 4 Under Development 14 100.00 Very High Very High Very High
Stress 28 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 418 99.82 Very High Very High Very High
Vibrio Infection 18 99.74 Very High Very High Very High
INFLAMMATION 487 99.48 Very High Very High Very High
Lung Injury 117 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An infusion of prostaglandin F2alpha, 2 microng/kg per min intraluminally, induced MAPC activity similar to that of the cholera complex.
Positive_regulation (induced) of MAPC associated with vibrio infection
1) Confidence 0.69 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 871161 Disease Relevance 0.74 Pain Relevance 0.29
We investigated the mechanism by which cholera enterotoxin stimulates MAPC activity.
Spec (investigated) Positive_regulation (stimulates) of MAPC associated with vibrio infection
2) Confidence 0.69 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 871161 Disease Relevance 0.70 Pain Relevance 0.31
Protein analyses showed that Egfr activity was highest in the tumors, and also up-regulated in Min/+ relative to WT enterocytes.
Positive_regulation (up-regulated) of Min in enterocytes associated with cancer
3) Confidence 0.67 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.08 Pain Relevance 0
Dietary arginine increased high-grade colon adenoma incidence in Apc(Min/+)Nos2(+/+) mice, but not in Nos2 knockout mice.
Neg (not) Positive_regulation (increased) of Apc in colon associated with targeted disruption and adenoma
4) Confidence 0.59 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.84 Pain Relevance 0.26
We demonstrate that [Ca(2+)](i) is significantly elevated in tumors of Apc(Min/+) mice relative to the adjacent normal-appearing mucosa.
Positive_regulation (elevated) of Apc associated with cancer
5) Confidence 0.50 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11809688 Disease Relevance 0.77 Pain Relevance 0.31
Since the identification of the APC gene and the presence of a naturally occurring autosomal dominantly transmitted mouse equivalent of FAP (known as the Multiple Intestinal Neoplasia or Min mouse) harboring a germline mutation in the mouse Apc gene (written Apc to designate mouse) questions concerning disease expression and penetrance could be addressed.
Positive_regulation (mutation) of Apc in germline associated with familial adenomatous polyposis, intestinal cancer and disease
6) Confidence 0.50 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.64 Pain Relevance 0
Dietary arginine increased high-grade colon adenoma incidence in Apc(Min/+)Nos2(+/+) mice, but not in Nos2 knockout mice.
Neg (not) Positive_regulation (increased) of Min in colon associated with targeted disruption and adenoma
7) Confidence 0.49 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.84 Pain Relevance 0.26
The NAG-1 transgenic mice (NAG-(Tg+)) were characterized, and then the antitumorigenic activity was evaluated with 2 colorectal carcinogenesis models: chemical induction with azoxymethane and genetic induction using the Apc(Min+) mutation.
Positive_regulation (induction) of Apc
8) Confidence 0.45 Published 2006 Journal Gastroenterology Section Body Doc Link 17101328 Disease Relevance 0 Pain Relevance 0
In colonic epithelium the APC gene appears to be present in two different forms, which gives rise to two mRNA transcripts, one being approximately 300 bases longer than the other with the largest being the most abundant [29,34].
Positive_regulation (present) of APC in epithelium associated with familial adenomatous polyposis
9) Confidence 0.43 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.90 Pain Relevance 0
Among these are sequencing of the full APC gene, combination of conformation strand gel electrophoresis (CSGE) screening and protein truncation test (PTT), protein truncation test alone and finally linkage analysis.
Positive_regulation (sequencing) of APC gene associated with familial adenomatous polyposis
10) Confidence 0.43 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.78 Pain Relevance 0
-catenin destruction; loss of APC function increases transcription of ?
Positive_regulation (increases) of APC associated with familial adenomatous polyposis
11) Confidence 0.43 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.06 Pain Relevance 0
Activated Protein C (APC), an endogenous anticoagulant, improves tissue microperfusion and endothelial cell survival in systemic inflammatory states such as sepsis, but intravenous administration may cause severe bleeding.
Positive_regulation (Activated) of APC in endothelial cell associated with inflammation, hemorrhage and sepsis
12) Confidence 0.43 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887192 Disease Relevance 0.60 Pain Relevance 0.05
It was established that in an inductive phase of immune response rotational stress increases the number of APC, intensifies DTH and suppresses proliferation in the regional lymph node.
Positive_regulation (increases) of APC in lymph node associated with stress
13) Confidence 0.41 Published 2008 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 18942470 Disease Relevance 0.26 Pain Relevance 0.24
An APC-independent proliferation could be excluded since both clones proliferated only marginally without APC and increasing the number of APC resulted in a higher proliferation.
Positive_regulation (increasing) of APC
14) Confidence 0.40 Published 1998 Journal Int. Immunol. Section Abstract Doc Link 9620607 Disease Relevance 0 Pain Relevance 0.58
Inhaled APC prevents deterioration of lung function in response to alveolar distention
Positive_regulation (Inhaled) of APC in lung
15) Confidence 0.40 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0 Pain Relevance 0
Colonic and intestinal adenocarcinomas arise as a direct result of the loss of function of the adenomatous polyposis coli (APC) gene and stabilization of ?
Positive_regulation (stabilization) of APC associated with adenocarcinoma and familial adenomatous polyposis
16) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.06 Pain Relevance 0.13
Every five minutes the dose of APC was increased as shown in Figure 1, up to a maximum dose of 100 ?
Positive_regulation (increased) of APC
17) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.14 Pain Relevance 0.04
We employed one sample t test to compare the size of the ProSense-680+ particles of APC?
Positive_regulation (particles) of APC associated with familial adenomatous polyposis
18) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.95 Pain Relevance 0.08
Colonic and intestinal adenocarcinomas arise as a direct result of the loss of function of the adenomatous polyposis coli (APC) gene and stabilization of ?
Positive_regulation (stabilization) of adenomatous polyposis coli associated with adenocarcinoma and familial adenomatous polyposis
19) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 1.06 Pain Relevance 0.13
The two genes, Apc and Siah1, which were found to be downregulated in Dll1 mutants, are known to act via ?
Positive_regulation (act) of Apc
20) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.30 Pain Relevance 0

General Comments

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