INT38190

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Context Info
Confidence 0.39
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.46
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Svs4) extracellular region (Svs4)
Anatomy Link Frequency
dendrites 1
spikes 1
PC-3 1
soma 1
Svs4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 56 99.72 Very High Very High Very High
halothane 12 99.40 Very High Very High Very High
Spinal cord 4 98.64 Very High Very High Very High
anesthesia 17 98.58 Very High Very High Very High
isoflurane 11 98.02 Very High Very High Very High
sodium channel 15 97.64 Very High Very High Very High
Calcium channel 10 96.12 Very High Very High Very High
Pyramidal cell 14 95.00 High High
tetrodotoxin 10 94.80 High High
Pain 2 77.40 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 2 100.00 Very High Very High Very High
Reprotox - General 1 2 96.00 Very High Very High Very High
Stress 8 91.76 High High
Pain 2 77.40 Quite High
Toxicity 2 73.12 Quite High
Hyperalgesia 1 72.08 Quite High
Cancer 2 67.84 Quite High
Necrosis 1 56.56 Quite High
Cognitive Disorder 1 48.24 Quite Low
Schizophrenia 1 39.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated that the ADP is rapidly attenuated in the axon, such that when it reaches the action potential initiation site in the axon it provides sufficient depolarization to trigger repetitive axonal spikes, but insufficient depolarization to inactivate sodium channels.
Negative_regulation (attenuated) of ADP in spikes associated with action potential and sodium channel
1) Confidence 0.39 Published 2009 Journal Neuron Section Body Doc Link PMC2777250 Disease Relevance 0 Pain Relevance 0.37
One investigation has found that cerebral ADP stayed constant during hypercarbia in rats that were anesthetized with halothane, while another observed that ADP decreased during supercarbia in rats that received no supplemental anesthesia.
Negative_regulation (decreased) of ADP associated with anesthesia and halothane
2) Confidence 0.38 Published 1986 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3711164 Disease Relevance 0 Pain Relevance 0.55
In contrast, hypercarbia during either isoflurane anesthesia or no anesthesia caused a decrease of only 10% in PCr, which meant that the calculated decrease in ADP was 60%, in agreement with the results of the second investigation.
Negative_regulation (decrease) of ADP associated with anesthesia and isoflurane
3) Confidence 0.38 Published 1986 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3711164 Disease Relevance 0 Pain Relevance 0.97
This ADP is blocked by replacing extracellular calcium with magnesium, by the application of the calcium-channel blocker cadmium, and by buffering intracellular calcium at near physiological levels.
Negative_regulation (blocked) of ADP
4) Confidence 0.38 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9325366 Disease Relevance 0 Pain Relevance 0.20
Finally, we show that the pronounced ADP is markedly attenuated in the axon, consistent with the hypothesis that the ADP is generated by high-voltage-activated calcium channels localized in the dendrites (Llinas and Yarom, 1981b).
Negative_regulation (attenuated) of ADP in dendrites associated with calcium channel
5) Confidence 0.29 Published 2009 Journal Neuron Section Body Doc Link PMC2777250 Disease Relevance 0 Pain Relevance 0.15
In contrast, the ADP was larger at the soma and strongly attenuated in the axon.
Negative_regulation (attenuated) of ADP in soma
6) Confidence 0.29 Published 2009 Journal Neuron Section Body Doc Link PMC2777250 Disease Relevance 0 Pain Relevance 0.05
ADP hydrolysis was decreased 25% in chronically stressed males, while no change was observed on ATPase activity.
Negative_regulation (decreased) of ADP
7) Confidence 0.06 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890946 Disease Relevance 0.77 Pain Relevance 0.35
A decrease in the initial slope of the ADP (?
Negative_regulation (decrease) of ADP
8) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088280 Disease Relevance 0 Pain Relevance 0.53
In vitro studies have confirmed the efficacy of growth factor inhibitors such as suramin in reducing cellular proliferation of androgen dependent LNCaP and independent PC-3 CaP cell lines as well as CaP cells obtained by primary culture.
Negative_regulation (reducing) of androgen dependent LNCaP in PC-3 associated with hyperplasia
9) Confidence 0.00 Published 1995 Journal Cancer Surv. Section Abstract Doc Link 7621460 Disease Relevance 0.69 Pain Relevance 0

General Comments

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