INT38201

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.35
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
head 3
caudate nucleus 2
substantia nigra 2
striatum 2
nervous system 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Botox 135 99.98 Very High Very High Very High
Substantia nigra 20 99.28 Very High Very High Very High
Neurotransmitter 3 97.60 Very High Very High Very High
antagonist 1 94.60 High High
tetrodotoxin 2 94.52 High High
anesthesia 1 90.64 High High
Sumatriptan 2 77.60 Quite High
Dopamine 2 73.44 Quite High
agonist 1 72.08 Quite High
Action potential 2 54.40 Quite High
Disease Link Frequency Relevance Heat
Movement Disorders 18 93.20 High High
Toxicity 3 85.52 High High
Gastroenteritis 3 79.92 Quite High
Poisoning 4 76.72 Quite High
Ocular Toxicity (including Many Sub-types) 18 74.88 Quite High
Hemifacial Spasm 18 73.68 Quite High
Paralysis 9 71.20 Quite High
Synkinesis 24 70.64 Quite High
Wound Healing 6 62.80 Quite High
Sialorrhea 15 58.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, application of acetylcholine into the substantia nigra induced an increase, while apomorphine induced a decrease in the release of acetylcholinesterase from the striatum.
Negative_regulation (decrease) of Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
1) Confidence 0.59 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.20
Both compounds reduced the release of acetylcholinesterase in the ipsilateral striatum.
Negative_regulation (reduced) of Localization (release) of acetylcholinesterase in striatum
2) Confidence 0.59 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.36
The spontaneous release of acetylcholinesterase was reduced in the ipsilateral caudate nucleus.
Negative_regulation (reduced) of Localization (release) of acetylcholinesterase in caudate nucleus
3) Confidence 0.53 Published 1982 Journal Neuroscience Section Abstract Doc Link 7155357 Disease Relevance 0 Pain Relevance 0.29
Drugs which inhibited raphé-stimulated release of AChE had no effect on concomitant animal rotation, indicating that the behavioural events are mediated via distinct processes, unrelated to those mediating nigral AChE release.
Negative_regulation (inhibited) of Localization (release) of AChE
4) Confidence 0.41 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532190 Disease Relevance 0 Pain Relevance 0.43
It has many structural similarities with naturally occurring compounds, and their primary target of action in insects is the nervous system; it also inhibit the release of the acetylcholinesterase at the synaptic junction [12].
Negative_regulation (inhibit) of Localization (release) of acetylcholinesterase in nervous system
5) Confidence 0.26 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0.30 Pain Relevance 0
Blocking the release of ACHE leads to a reduction of pathological movement of muscles and secretion of glands in the head and neck area increasing the quality of life for patients.
Negative_regulation (Blocking) of Localization (release) of ACHE in head
6) Confidence 0.02 Published 2008 Journal Head Face Med Section Body Doc Link PMC2292691 Disease Relevance 0.76 Pain Relevance 0.18
BTA prevents the release of acetylcholine (ACHE) in synapses.
Negative_regulation (prevents) of Localization (release) of ACHE in synapses associated with botox
7) Confidence 0.02 Published 2008 Journal Head Face Med Section Body Doc Link PMC2292691 Disease Relevance 0.54 Pain Relevance 0.19
Blocking the release of ACHE leads to a reduction of pathological movement of muscles and secretion of glands in the head and neck area increasing the quality of life for patients.
Negative_regulation (Blocking) of in neck Localization (release) of ACHE in head
8) Confidence 0.01 Published 2008 Journal Head Face Med Section Body Doc Link PMC2292691 Disease Relevance 0.76 Pain Relevance 0.18

General Comments

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