INT38203

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Context Info
Confidence 0.39
First Reported 1986
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.27
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Txnrd1) cytosol (Txnrd1) mitochondrion (Txnrd1)
sulfur compound metabolic process (Txnrd1) nucleolus (Txnrd1) nucleus (Txnrd1)
Anatomy Link Frequency
motoneurons 2
hepatocytes 1
Txnrd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
induced neuropathy 3 80.56 Quite High
Enkephalin 2 75.00 Quite High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the biliary excretion index and biliary clearance decreased by 83 and 85%, respectively, in TR- SC rat hepatocytes, indicating that DPDPE is an Mrp2 substrate.
Negative_regulation (decreased) of TR in hepatocytes
1) Confidence 0.39 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15528320 Disease Relevance 0 Pain Relevance 0.20
A single 50 mg/kg i.p. dose of ACR resulted in a 33.4% decrease in NADH-tetrazolium reductase (NADH-TR) (indicative of oxidative metabolism) activity in rat soleus motoneurons within one hour of injection.
Negative_regulation (decrease) of NADH-TR in motoneurons
2) Confidence 0.32 Published 1986 Journal Neurotoxicology Section Abstract Doc Link 3714120 Disease Relevance 0.10 Pain Relevance 0
Methylene bis ACR (Mb-ACR), a non-neurotoxic analogue, produced a much smaller (6.7%) decrease in NADH-TR activity.
Negative_regulation (decrease) of NADH-TR
3) Confidence 0.32 Published 1986 Journal Neurotoxicology Section Abstract Doc Link 3714120 Disease Relevance 0.09 Pain Relevance 0.07
In vitro histochemical assays demonstrated a dose-dependent inhibition of motoneuron NADH-TR activity (10-54%) by 1-10mM ACR.
Negative_regulation (inhibition) of NADH-TR in motoneuron
4) Confidence 0.20 Published 1986 Journal Neurotoxicology Section Abstract Doc Link 3714120 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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