INT38204

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Context Info
Confidence 0.66
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.23
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Acr) molecular_function (Acr) protein complex (Acr)
Anatomy Link Frequency
limbs 1
Acr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Fibrositis 224 99.98 Very High Very High Very High
Pain 156 98.14 Very High Very High Very High
anesthesia 2 96.48 Very High Very High Very High
Lasting pain 48 95.72 Very High Very High Very High
Analgesic 2 79.48 Quite High
Inflammation 2 78.92 Quite High
induced neuropathy 2 61.68 Quite High
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Acupuncture 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 224 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 3 99.64 Very High Very High Very High
Pain 200 98.14 Very High Very High Very High
Poisoning 1 97.84 Very High Very High Very High
Neuropathic Pain 4 91.12 High High
Congenital Anomalies 1 84.16 Quite High
Ataxia 1 82.96 Quite High
INFLAMMATION 2 78.92 Quite High
Muscle Weakness 1 68.72 Quite High
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylene bis ACR (Mb-ACR), a non-neurotoxic analogue, produced a much smaller (6.7%) decrease in NADH-TR activity.
Gene_expression (produced) of ACR
1) Confidence 0.66 Published 1986 Journal Neurotoxicology Section Abstract Doc Link 3714120 Disease Relevance 0.09 Pain Relevance 0.06
Methylene bis ACR (Mb-ACR), a non-neurotoxic analogue, produced a much smaller (6.7%) decrease in NADH-TR activity.
Gene_expression (produced) of ACR
2) Confidence 0.58 Published 1986 Journal Neurotoxicology Section Abstract Doc Link 3714120 Disease Relevance 0.09 Pain Relevance 0.06
Instead, dose-rate determined onset and progression of neurotoxicity, e.g. the higher ACR dose-rate produced moderate neurotoxicity after approximately 8 days of intoxication, whereas the lower dose-rate caused moderate neurotoxicity after 26 days.
Gene_expression (produced) of ACR associated with drug induced neurotoxicity and poisoning
3) Confidence 0.53 Published 2002 Journal Neurotoxicology Section Abstract Doc Link 12164553 Disease Relevance 0.63 Pain Relevance 0.10
Based on the review of the literature we hypothesised that: a) WSP is common in the population, b) considerable differences in prevalences of WSP exist between the ACR and Manchester definitions, c) WSP is more common in women than in men and increases with age d) not only chronic pain but also spreading of pain (i.e., WSP) is associated with increased consumption of health care and work disability.
Gene_expression (exist) of ACR associated with pain, lasting pain and fibrositis
4) Confidence 0.14 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2488345 Disease Relevance 1.76 Pain Relevance 1.39
Different definitions of WSP have been used in the literature, e.g.,: 1) pain at more than three locations in both the upper and lower half of the body [4]; 2) pain in at least two sections of two contra lateral limbs and in the axial skeleton (i.e., the Manchester definition) [13]; and 3) pain is considered widespread when all of the following are present: pain in the left side of the body, pain in the right side of the body, pain above the waist, and pain below the waist; axial skeletal pain (cervical spine or anterior chest or thoracic spine or low back) must be present (i.e., the ACR definition of chronic WSP as part of the classification criteria for FMS) [18].
Gene_expression (definition) of ACR in limbs associated with pain and fibrositis
5) Confidence 0.14 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2488345 Disease Relevance 1.66 Pain Relevance 1.24

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