INT3821

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Context Info
Confidence 0.42
First Reported 1977
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.89
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1s) extracellular region (C1s) molecular_function (C1s)
Anatomy Link Frequency
abdomen 1
C1s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 99.94 Very High Very High Very High
abdominal pain 14 98.68 Very High Very High Very High
interstitial cystitis 2 98.20 Very High Very High Very High
Inflammation 1 89.56 High High
cva 1 88.80 High High
analgesia 5 84.88 Quite High
epidural 2 75.00 Quite High
corticosteroid 1 72.96 Quite High
Antihistamine 1 71.60 Quite High
pruritus 1 70.40 Quite High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 19 99.16 Very High Very High Very High
Abdominal Pain 14 98.68 Very High Very High Very High
Interstitial Cystitis 2 98.20 Very High Very High Very High
Acute Abdomen 3 98.00 Very High Very High Very High
Pressure And Volume Under Development 33 97.92 Very High Very High Very High
Death 1 97.68 Very High Very High Very High
Asphyxia 1 97.08 Very High Very High Very High
Insect Bites And Stings 1 97.04 Very High Very High Very High
Emergencies 9 96.72 Very High Very High Very High
Syndrome 3 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE-inhibitors, NSAID), C1-esterase deficiency and other causes.
Negative_regulation (deficiency) of C1-esterase associated with cinod
1) Confidence 0.42 Published 2004 Journal Ther Umsch Section Abstract Doc Link 15195721 Disease Relevance 0.35 Pain Relevance 0.10
Acquired C1-esterase inhibitor deficiency: a rare cause of episodic acute abdominal pain and ascites.
Negative_regulation (deficiency) of C1-esterase associated with pressure and volume under development and abdominal pain
2) Confidence 0.42 Published 2003 Journal Eur J Emerg Med Section Title Doc Link 12972907 Disease Relevance 0.87 Pain Relevance 0.19
We describe a typical case of acquired C1-esterase inhibitor deficiency in a 65-year-old woman presenting with recurrent acute abdomen and ascites who had undergone two negative surgical interventions before diagnosis was eventually established.
Negative_regulation (deficiency) of C1-esterase in abdomen associated with pressure and volume under development and acute abdomen
3) Confidence 0.42 Published 2003 Journal Eur J Emerg Med Section Abstract Doc Link 12972907 Disease Relevance 0.87 Pain Relevance 0.17
C1-esterase inhibitor deficiency is a rare yet classic medical cause of acute abdominal pain mimicking a surgical emergency.
Negative_regulation (deficiency) of C1-esterase associated with abdominal pain and emergencies
4) Confidence 0.42 Published 2003 Journal Eur J Emerg Med Section Abstract Doc Link 12972907 Disease Relevance 0.71 Pain Relevance 0.17
Diagnostic and therapeutic problems associated with hereditary deficiency of the C1 esterase inhibitor.
Negative_regulation (deficiency) of C1 esterase
5) Confidence 0.28 Published 1977 Journal Clin. Allergy Section Title Doc Link 872360 Disease Relevance 0.56 Pain Relevance 0.09
Hereditary angioedema (HAE) is the autosomal dominant deficiency of C1-esterase inhibitor.
Negative_regulation (inhibitor) of C1-esterase associated with hereditary angioedema
6) Confidence 0.24 Published 2001 Journal Pediatr Radiol Section Abstract Doc Link 11321752 Disease Relevance 1.20 Pain Relevance 0.26
Low levels of C4, and absence of C1 esterase inhibitor confirm the diagnosis.
Negative_regulation (inhibitor) of C1 esterase
7) Confidence 0.20 Published 1977 Journal Clin. Allergy Section Abstract Doc Link 872360 Disease Relevance 0.53 Pain Relevance 0.09
The diagnosis can be confirmed by finding low levels of C1 esterase inhibitor, C4 and C2.
Negative_regulation (inhibitor) of C1 esterase
8) Confidence 0.19 Published 1992 Journal J Assoc Physicians India Section Abstract Doc Link 1452538 Disease Relevance 0.63 Pain Relevance 0.09
Quantitative and functional analyses of C1 esterase inhibitor and complement components C4 and C1q should be performed when HAE is suspected.
Negative_regulation (inhibitor) of C1 esterase associated with hereditary angioedema
9) Confidence 0.13 Published 2001 Journal Arch. Intern. Med. Section Abstract Doc Link 11700154 Disease Relevance 1.14 Pain Relevance 0.11
Sera from 41 patients with interstitial cystitis were tested for immunoglobulins (IgA, G, M), complement components (C1q, C3, C4) and for C1-esterase inhibitor.
Negative_regulation (inhibitor) of C1-esterase associated with interstitial cystitis
10) Confidence 0.06 Published 1983 Journal Eur. Urol. Section Abstract Doc Link 6606579 Disease Relevance 0.17 Pain Relevance 0.17
Low C1 esterase inhibitor confirm the diagnosis.
Negative_regulation (inhibitor) of C1 esterase
11) Confidence 0.05 Published 2006 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 16556528 Disease Relevance 0.61 Pain Relevance 0.14
A decrease in plasminogen and alpha 2-antiplasmin suggested activation of the fibrinolytic system and a decrease in prekallikrein and kallikrein inhibition activity (C-1-esterase inhibitor) an activation of the kallikrein system.
Negative_regulation (inhibitor) of C-1-esterase
12) Confidence 0.01 Published 1986 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3739576 Disease Relevance 0.07 Pain Relevance 0.50
METHODS AND RESULTS: We determined serially in the patients up to 10 days after admission factor XII and the beta-factor XIIa inhibition, kallikrein-like activity, prekallikrein, C1-esterase inhibitor, kallikrein inhibition, high molecular weight kininogen as indicators of the contact phase and bradykinin generation, thrombin-antithrombin III (TAT) complex as marker of the activated coagulation cascade, fibrinogen, plasminogen, plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (TPA), and D-dimers as indicators of the fibrinolytic system.
Negative_regulation (inhibitor) of C1-esterase
13) Confidence 0.01 Published 1995 Journal Circulation Section Body Doc Link 7743613 Disease Relevance 0.18 Pain Relevance 0

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