INT3823

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 19.49
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPI)
Anatomy Link Frequency
foot 2
blood 2
osteoblast 2
muscle 1
nephron 1
ALPI (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 4 99.80 Very High Very High Very High
Pain 22 99.54 Very High Very High Very High
pain flank 1 99.04 Very High Very High Very High
Analgesic 4 99.00 Very High Very High Very High
Bile 176 94.24 High High
cINOD 1 84.04 Quite High
imagery 10 83.92 Quite High
Pain refractory 1 82.44 Quite High
pruritus 30 81.00 Quite High
positron emission tomography 1 80.08 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 174 100.00 Very High Very High Very High
Calcification 48 100.00 Very High Very High Very High
Anaemia 11 99.96 Very High Very High Very High
Pressure And Volume Under Development 15 99.92 Very High Very High Very High
Hypophosphatemia 8 99.90 Very High Very High Very High
Osteogenic Sarcomas 5 99.86 Very High Very High Very High
Cancer 108 99.84 Very High Very High Very High
Splenomegaly 1 99.82 Very High Very High Very High
Abdominal Pain 4 99.80 Very High Very High Very High
Disease 134 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
He presented with gradual onset of muscle weakness and painful cramp of the bilateral quadriceps femoris muscles, followed by low inorganic phosphorus, elevated alkaline phosphatase in the serum and hyperphosphaturia.
Positive_regulation (elevated) of alkaline phosphatase in muscle associated with cramps, pain, familial hypophosphatemia and muscle weakness
1) Confidence 0.69 Published 1995 Journal Rinsho Shinkeigaku Section Abstract Doc Link 7781239 Disease Relevance 0.54 Pain Relevance 0.10
Workers exposed to mercury, which affects the S3 segment, showed an increased IAP elimination; abusers of analgesics, which affect more distal parts of the nephron, did not.
Positive_regulation (increased) of IAP in nephron associated with analgesic
2) Confidence 0.69 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1582013 Disease Relevance 0 Pain Relevance 0.10
Aggravating severe hypophosphatemia and elevated serum alkaline phosphatase levels with high bone fraction had been noted after 6 months of ADV therapy.
Positive_regulation (elevated) of serum alkaline phosphatase associated with hypophosphatemia
3) Confidence 0.68 Published 2008 Journal The Korean journal of hepatology Section Abstract Doc Link 18815461 Disease Relevance 1.20 Pain Relevance 0.09
Leukocytosis with marked eosionphilia and elevated serum alkaline phosphatase were noted.
Positive_regulation (elevated) of serum alkaline phosphatase associated with leukocytosis
4) Confidence 0.66 Published 2006 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 16911704 Disease Relevance 0.52 Pain Relevance 0.17
The diagnosis of Paget's disease was confirmed four months before admission, but pain and elevated serum alkaline phosphatase levels remained despite treatment with i.v. bisphosphonates.
Positive_regulation (elevated) of serum alkaline phosphatase associated with pain
5) Confidence 0.64 Published 2006 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 17091439 Disease Relevance 0.70 Pain Relevance 0.19
Therefore, the only indication of possible diffusion of the disease to bone was increased serum alkaline phosphatase.
Positive_regulation (increased) of serum alkaline phosphatase associated with disease
6) Confidence 0.55 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1896169 Disease Relevance 1.10 Pain Relevance 0.14
We present the case of a 38-year-old man in whom extensive bilateral melorheostosis was associated with elevated serum alkaline phosphatase, swelling of the right foot and progressive deformity of the left hand, left leg and right foot.
Positive_regulation (elevated) of serum alkaline phosphatase in foot associated with pressure and volume under development and melorheostosis
7) Confidence 0.54 Published 2002 Journal Skeletal Radiol. Section Abstract Doc Link 12483433 Disease Relevance 0.43 Pain Relevance 0.08
Following treatment with bisphosphonate (30 mg/day of pamidronate for 6 days) infusion, the pain and swelling of his right foot showed improvement and his elevated serum alkaline phosphatase decreased.
Positive_regulation (elevated) of serum alkaline phosphatase in foot associated with pain and pressure and volume under development
8) Confidence 0.54 Published 2002 Journal Skeletal Radiol. Section Abstract Doc Link 12483433 Disease Relevance 0.45 Pain Relevance 0.10
INVESTIGATIONS: Laboratory findings were elevated levels of serum alkaline phosphatase (AP), CA 19-9 and CEA.
Positive_regulation (elevated) of serum alkaline phosphatase
9) Confidence 0.43 Published 2006 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 17091439 Disease Relevance 0.10 Pain Relevance 0
Normal renal tubular function, blood pH, and serum concentration of 25-hydroxycholecalciferol and elevated serum alkaline phosphatase excluded the common causes of osteomalacia.
Positive_regulation (elevated) of serum alkaline phosphatase in blood associated with rickets
10) Confidence 0.35 Published 1977 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 874058 Disease Relevance 0.73 Pain Relevance 0.07
Left flank pain occurred several days after admission, and the serum alkaline phosphatase level increased between days 5 and 12 following admission.
Positive_regulation (increased) of serum alkaline phosphatase associated with pain flank
11) Confidence 0.33 Published 2007 Journal Angiology Section Abstract Doc Link 17875963 Disease Relevance 1.15 Pain Relevance 0.10
However, pertinent laboratory data were notable for hypocalcemia (7.5 mg/dL, albumin 4.1 mg/dL) with low urinary calcium excretion (14 mg/day), hypophosphatemia (2.0 mg/dL) with low urinary phosphate excretion (53 mg/day), hypomagnesemia (1.5 mg/dL) with low urine magnesium excretion (23 mg/day), low 1, 25 (OH)2 vitamin D3, and elevated serum alkaline phosphatase and intact parathyroid hormone (iPTH).
Positive_regulation (elevated) of serum alkaline phosphatase in parathyroid associated with hypomagnesemia, hypocalcemia and hypophosphatemia
12) Confidence 0.23 Published 2010 Journal South. Med. J. Section Abstract Doc Link 20710144 Disease Relevance 0.99 Pain Relevance 0.24
The side effects that were observed were medullary pain, splenomegaly, and an elevation of levels of leukocyte alkaline phosphatase.
Positive_regulation (elevation) of leukocyte alkaline phosphatase in leukocyte associated with pain and splenomegaly
13) Confidence 0.15 Published 1989 Journal N. Engl. J. Med. Section Abstract Doc Link 2471075 Disease Relevance 0.77 Pain Relevance 0.10
The levels of serum biochemical markers of bone metabolism were all within normal ranges except for mild elevation of the serum alkaline phosphatase level.
Neg (except) Positive_regulation (elevation) of serum alkaline phosphatase
14) Confidence 0.13 Published 1997 Journal J. Pediatr. Section Body Doc Link 9386665 Disease Relevance 0 Pain Relevance 0
Laboratory analysis revealed elevated total bilirubin (23.5 mg/dl), with predominant direct bilirubin and an increased serum level of alkaline phosphatase and GGT, AST, ALT.
Positive_regulation (increased) of alkaline phosphatase
15) Confidence 0.09 Published 2010 Journal Chirurgia (Bucur) Section Abstract Doc Link 20540247 Disease Relevance 0.82 Pain Relevance 0.18
s polymorphism presenting with platelet Gs hyperfunction, brachydactyly, increased alkaline phosphatase and neurological problems or growth deficiency [9, 17].
Positive_regulation (increased) of alkaline phosphatase in platelet
16) Confidence 0.09 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 0.81 Pain Relevance 0.08
The clinical features of DMAC infection are fever, weight loss, abdominal pain, anemia, elevated serum alkaline phosphatase, and elevated serum lactate dehydrogenase.
Positive_regulation (elevated) of serum alkaline phosphatase associated with abdominal pain, anaemia, weight loss, fever and infection
17) Confidence 0.07 Published 1998 Journal Int. J. Infect. Dis. Section Abstract Doc Link 9831675 Disease Relevance 1.10 Pain Relevance 0.10
Treatment with bortezomib caused a significant increase in bone-specific alkaline phosphatase and pro-collagen type I N-terminal propeptide, a novel bone formation marker.
Positive_regulation (increase) of alkaline phosphatase
18) Confidence 0.06 Published 2010 Journal European Journal of Haematology Section Abstract Doc Link PMC2970902 Disease Relevance 0.45 Pain Relevance 0
Serum alkaline phosphatase was elevated with a level of 173 U/l (normal value: 35–104 U/l).
Positive_regulation (elevated) of Serum alkaline phosphatase
19) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2241629 Disease Relevance 0.81 Pain Relevance 0.11
Evidence suggesting that bortezomib, the first clinically available proteasome inhibitor, could overcome the osteoblast inhibition observed in MM was provided from the APEX trial where serum alkaline phosphatase (AP) was found to be increased in patients responding to bortezomib treatment (21).
Positive_regulation (increased) of alkaline phosphatase in osteoblast associated with osteoporosis and multiple myeloma
20) Confidence 0.05 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 1.05 Pain Relevance 0

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