INT3824

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 28.58
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 12
plasma 3
Lips 2
urine 2
gland 1
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 17 100.00 Very High Very High Very High
anesthesia 4 99.60 Very High Very High Very High
alcohol 21 98.06 Very High Very High Very High
Dismenorea 1 97.12 Very High Very High Very High
pruritus 3 97.00 Very High Very High Very High
Pain 76 96.08 Very High Very High Very High
palliative 5 88.00 High High
analgesia 1 86.68 High High
agonist 1 83.52 Quite High
rheumatoid arthritis 10 83.00 Quite High
Disease Link Frequency Relevance Heat
Headache 15 100.00 Very High Very High Very High
Hypoparathyroidism 2 99.62 Very High Very High Very High
Hypercalcemia 324 99.56 Very High Very High Very High
Hypocalcemia 37 99.48 Very High Very High Very High
Bone Cancer 31 99.04 Very High Very High Very High
Congenital Anomalies 11 98.78 Very High Very High Very High
Pleurisy 2 98.74 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 98.60 Very High Very High Very High
Kidney Stones 31 98.40 Very High Very High Very High
Rickets 21 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduced parathormone (PTH) level was found among the female HIV-infected patients.
Negative_regulation (reduced) of PTH associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.59 Published 1997 Journal Eur. J. Med. Res. Section Abstract Doc Link 9262487 Disease Relevance 1.01 Pain Relevance 0
CONCLUSION: Ultrasound-guided percutaneous ethanol injection may be employed to palliate parathyroid carcinoma in selected cases, with a transitory decrease in PTH and calcium levels.


Negative_regulation (decrease) of PTH in parathyroid
2) Confidence 0.58 Published 2008 Journal Arq Bras Endocrinol Metabol Section Body Doc Link 18604386 Disease Relevance 0.06 Pain Relevance 0
Two patients showed a prompt decrease of PTH after removal of the single enlarged gland, featuring the kinetics observed in the adenomas.
Negative_regulation (decrease) of PTH in gland associated with adenoma
3) Confidence 0.57 Published 2000 Journal World J Surg Section Abstract Doc Link 10787076 Disease Relevance 0.72 Pain Relevance 0.08
The suppressed PTH intact level found back to normal values within 8 weeks.
Negative_regulation (suppressed) of PTH
4) Confidence 0.57 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2241629 Disease Relevance 0.62 Pain Relevance 0.14
The levels of intact parathyroid hormone decreased rapidly and serum concentration of alkaline phosphatase gradually decreased for a few months postoperatively.
Negative_regulation (decreased) of parathyroid hormone in parathyroid
5) Confidence 0.57 Published 1992 Journal Hinyokika Kiyo Section Abstract Doc Link 1609662 Disease Relevance 0.85 Pain Relevance 0.14
Serum parathyroid hormone levels (mid-molecule assay) were suppressed before treatment (64 +/- 16 pg/ml), but rose rapidly to 223 +/- 68 pg/ml by Day 7 of treatment.
Negative_regulation (suppressed) of parathyroid hormone in parathyroid
6) Confidence 0.57 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3030098 Disease Relevance 0.54 Pain Relevance 0.08
Postoperatively, the i-PTH level decreased immediately and calcium phosphate product was maintained in the reference range.
Negative_regulation (decreased) of PTH
7) Confidence 0.57 Published 2008 Journal Clin. Nephrol. Section Abstract Doc Link 18218318 Disease Relevance 1.75 Pain Relevance 0.05
Sato et al.19 showed in a randomized placebo-controlled 56-week study conducted on 98 hemiplegic patients following stroke that 56 weeks of cyclical etidronate treatment (400 mg/day for 2 weeks every 14 weeks) did not only retard the immobilization-induced loss of the metacarpal BMD by decreasing the serum pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (1CTP) level, but also decreased the serum parathyroid hormone level and improved hypercalcemia, which was followed by an increased serum 1,25-dihydroxyvitamin D level.
Negative_regulation (decreased) of parathyroid hormone in parathyroid associated with stroke and hypercalcemia
8) Confidence 0.57 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 1.08 Pain Relevance 0.03
The present data confirm that both doses produced a significant suppression of PTH.
Negative_regulation (suppression) of PTH
9) Confidence 0.56 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0 Pain Relevance 0
Laboratory findings revealed a decreased parathyroid hormone (PTH) level and marked elevation of parathyroid hormone-related protein (PTHRP).
Negative_regulation (decreased) of PTH in parathyroid
10) Confidence 0.55 Published 1995 Journal Surg. Today Section Abstract Doc Link 8640024 Disease Relevance 1.10 Pain Relevance 0.09
A reduced parathormone (PTH) level was found among the female HIV-infected patients.
Negative_regulation (reduced) of parathormone associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.51 Published 1997 Journal Eur. J. Med. Res. Section Abstract Doc Link 9262487 Disease Relevance 1.01 Pain Relevance 0
A pharmacologic dose of 1 alpha-hydroxyvitamin D3 or or 1,25-dihydroxyvitamin D3 slightly increased the serum phosphate level and renal tubular reabsorption of phosphate, and slightly decreased plasma PTH level without any symptomatic improvement.
Negative_regulation (decreased) of PTH in plasma
12) Confidence 0.50 Published 1997 Journal Korean J. Intern. Med. Section Abstract Doc Link 9159046 Disease Relevance 1.00 Pain Relevance 0.14
The now available calcimimetic cinacalcet was prescribed eventually at a maximum dose of 90 mg twice daily, which decreased PTH concentrations from 120 pmol/l to 85 pmol/l, stabilised calcium concentrations to about 2.80 mmol/l and stabilised creatinine clearance at 51 ml/min.
Negative_regulation (decreased) of PTH associated with disorders of creatine metabolism
13) Confidence 0.43 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.65 Pain Relevance 0
The data are consistent with the hypothsis that lack of parathyroid hormone causes both hypocalcemia and a decreased serum concentration of 1,25-dihydroxycholecalciferol which, in turn, limit the availability of calcium and cause defective synthesis of bone matrix resulting in abnormal mineralization.
Negative_regulation (lack) of parathyroid hormone in parathyroid associated with hypocalcemia
14) Confidence 0.42 Published 1977 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 874058 Disease Relevance 0.72 Pain Relevance 0.07
The serum abnormalities were due to idiopathic hypoparathyroidism as evidenced by a decreased serum concentration of parathyroid hormone and an appropriate rise in urinary cyclic AMP and phosphate excretion, and serum calcium concentration, in response to exogenously administered parathyroid extract.
Negative_regulation (decreased) of parathyroid hormone in parathyroid associated with hypoparathyroidism and congenital anomalies
15) Confidence 0.42 Published 1977 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 874058 Disease Relevance 0.67 Pain Relevance 0.09
To clinicians this seems counterintuitive, because the elevated levels of parathyroid hormone (PTH) found in hyperparathyroidism typically result in reduced BMD and increased fracture risk.
Negative_regulation (levels) of parathyroid hormone in parathyroid associated with hypercalcemia
16) Confidence 0.42 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.71 Pain Relevance 0.04
To clinicians this seems counterintuitive, because the elevated levels of parathyroid hormone (PTH) found in hyperparathyroidism typically result in reduced BMD and increased fracture risk.
Negative_regulation (levels) of PTH in parathyroid associated with hypercalcemia
17) Confidence 0.42 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.71 Pain Relevance 0.04
[Surgery of primary hyperparathyroidism by unilateral approach under local anesthesia and intraoperative determination of PTH 1-84].
Negative_regulation (determination) of PTH 1 associated with anesthesia and hypercalcemia
18) Confidence 0.41 Published 1994 Journal Ann. Endocrinol. (Paris) Section Title Doc Link 7857082 Disease Relevance 0.40 Pain Relevance 0.27
The box-plots in Figure 2 suggest a somewhat greater PTH suppression with the higher dose of vitamin D, and we attribute the lack of a statistical difference in PTH between the dose groups to the relatively small sample sizes in this study.
Negative_regulation (suppression) of PTH
19) Confidence 0.41 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0 Pain Relevance 0
In both groups, statistically significant suppression of PTH was detected only after 6 months of supplementation.
Negative_regulation (suppression) of PTH
20) Confidence 0.41 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0 Pain Relevance 0

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