INT38249

Context Info Confidence 0.40 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 2.58 Pain Relevance 3.96

nucleolus (VIPR1) plasma membrane (VIPR1) nucleus (VIPR1) cytoplasm (VIPR1) signal transducer activity (VIPR1)

Anatomy Link Frequency plasma 2 platelet 1 dorsal root ganglia 1 oocytes 1 respiratory 1 VIPR1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 18 100.00 Pain 2 100.00 antagonist 12 99.20 Analgesic 3 99.12 agonist 8 98.64 transcutaneous nerve stimulation 2 98.52 alcohol 3 97.68 nociceptor 4 97.20 Opioid 1 96.68 Serotonin 1 96.20

Disease Link Frequency Relevance Heat Pain 2 100.00 Hypoxia 53 99.24 Respiratory Failure 1 88.48 Cv General 3 Under Development 4 80.56 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 66.88 Depression 1 64.56 Hypocapnia 4 57.68 Alkalosis 3 56.48 Pressure And Volume Under Development 24 52.64 Cancer 119 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have previously shown that plasma vasoactive intestinal polypeptide (VIP) is increased in normal subjects by low-frequency transcutaneous nerve stimulation.

Positive_regulation (increased) of plasma vasoactive intestinal polypeptide in plasma associated with transcutaneous nerve stimulation

1) Confidence 0.40 Published 1986 Journal Gen. Pharmacol. Section Abstract Doc Link 3721187 Disease Relevance 0.07 Pain Relevance 0.17

Increase in plasma vasoactive intestinal polypeptide (VIP) in muscular exercise in humans.

Positive_regulation (Increase) of plasma vasoactive intestinal polypeptide in plasma

2) Confidence 0.35 Published 1986 Journal Gen. Pharmacol. Section Title Doc Link 3721187 Disease Relevance 0.14 Pain Relevance 0.23

HVR was also augmented by domperidone in hypoxic cats, but remained below that of controls.

Positive_regulation (augmented) of HVR associated with hypoxia

3) Confidence 0.21 Published 1995 Journal Respir Physiol Section Abstract Doc Link 8525121 Disease Relevance 1.27 Pain Relevance 0.39

the previous orphan receptor RDC1 is now recognized as an additional CXCL12 receptor,

Positive_regulation (orphan receptor) of RDC1

4) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.07 Pain Relevance 0.07

For both rVR1 and hVR1, time-response waveforms elicited by resiniferatoxin increased more gradually compared to other agonists.

Positive_regulation (increased) of hVR1 associated with agonist

5) Confidence 0.10 Published 2002 Journal J Biomol Screen Section Abstract Doc Link 14599363 Disease Relevance 0 Pain Relevance 0.61

Capsaicin (EC(50) = 853 nM), low pH (<5.5), and noxious heat (44 degrees C) activate hVR1 expressed in Xenopus oocytes.

Positive_regulation (activate) of hVR1 in oocytes associated with qutenza

6) Confidence 0.06 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11243859 Disease Relevance 0.08 Pain Relevance 0.79

Given the potential importance of VR1 in pain, we have cloned the human capsaicin receptor, hVR1, from a human dorsal root ganglia (DRG) cDNA library.

Positive_regulation (importance) of hVR1 in dorsal root ganglia associated with pain and qutenza

7) Confidence 0.04 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11243859 Disease Relevance 0.10 Pain Relevance 0.85

General metabolic stimulants, such as caffeine and cocoa; and respiratory stimulants, such as progesterone, increase the HVR.[11] On the other hand, respiratory depressants, such as alcohol and fragmented sleep, depress the HVR.

Positive_regulation (increase) of HVR in respiratory associated with alcohol

8) Confidence 0.03 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.39 Pain Relevance 0.09

In addition, the late phase of the HVR is mediated in part through platelet-derived growth factor (PDGF)-beta receptors.

Positive_regulation (mediated) of HVR in platelet

9) Confidence 0.02 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15950554 Disease Relevance 0.46 Pain Relevance 0.75

General Comments

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