INT38250

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.83
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syt17) molecular_function (Syt17) biological_process (Syt17)
Anatomy Link Frequency
Golgi cells 2
spike 1
neurons 1
cerebellar cortex 1
Syt17 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 18 100.00 Very High Very High Very High
dorsal root ganglion 3 98.92 Very High Very High Very High
antagonist 1 98.20 Very High Very High Very High
substance P 3 97.72 Very High Very High Very High
c fibre 1 92.72 High High
potassium channel 8 91.92 High High
agonist 1 89.44 High High
dexamethasone 1 88.16 High High
aspirin 1 86.76 High High
nociceptor 6 83.76 Quite High
Disease Link Frequency Relevance Heat
Ataxia 84 99.60 Very High Very High Very High
Ganglion Cysts 3 98.92 Very High Very High Very High
Nociception 2 84.72 Quite High
Pain 7 83.20 Quite High
Inflammatory Pain 2 75.00 Quite High
Hyperalgesia 2 74.24 Quite High
INFLAMMATION 2 60.32 Quite High
Camurati-engelmann Disease 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin (BK) inhibitor caused a inhibition of both first and second phases, and pretreatment of compound 48/80 and indomethacin inhibited only the second phase.
Negative_regulation (inhibitor) of BK associated with bradykinin
1) Confidence 0.38 Published 1986 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3721360 Disease Relevance 0.57 Pain Relevance 1.44
BK clearly increased intracellular calcium in cultured dorsal root ganglion (DRG) neurons of TRPV1-KO mice, although the incidence of BK-sensitive neurons was reduced.
Negative_regulation (reduced) of BK in neurons associated with ganglion cysts, dorsal root ganglion and bradykinin
2) Confidence 0.19 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18789982 Disease Relevance 0.72 Pain Relevance 1.40
Statistical analysis confirmed the absence of a significant difference in the latency of complex spike response (Fig. 6G) and the shorter duration in simple spike inhibition of BK?
Negative_regulation (inhibition) of BK in spike
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0 Pain Relevance 0
Therefore, loss of Golgi cell BK channels and the fact that their firing discharges were continuously phase-locked to beta oscillation in BK?
Negative_regulation (loss) of BK in Golgi cell
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.15 Pain Relevance 0.03
Inactivation of BK channels in mice, either by targeted deletion or pharmacological blockade, locks Purkinje and Golgi cells in highly rhythmic and synchronous firing, which possibly results in motor impairment.
Negative_regulation (Inactivation) of BK in Golgi cells
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.29 Pain Relevance 0
We demonstrated that either genetic or pharmacological BK inactivation leads to ataxia and to the emergence of a beta oscillatory field potential in the cerebellar cortex.
Negative_regulation (inactivation) of BK in cerebellar cortex associated with ataxia
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2776494 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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