INT38251

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1984
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 1.37
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Anatomy Link Frequency
liver 2
hepatocyte 2
kidney 2
L-2 1
Gclc (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
Paracetamol 70 97.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 8 84.64 Quite High
Hepatotoxicity 3 79.92 Quite High
Stress 8 75.00 Quite High
Toxicity 10 63.04 Quite High
Stupor 2 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, APAP and CCl(4) both increased gamma-GCS(h) mRNA and protein; however, there was a marked dose-dependent decrease in gamma-GCS activity.
Negative_regulation (decrease) of gamma-GCS
1) Confidence 0.57 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.21 Pain Relevance 0.06
To determine whether protection against acetaminophen-induced liver and kidney damage involved ribose cysteine dependent GSH biosynthesis, buthionine sulfoximine was used to selectively block gamma-glutamylcysteine synthetase (gamma-GCS).
Negative_regulation (block) of gamma-GCS in kidney associated with paracetamol
2) Confidence 0.54 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15910414 Disease Relevance 0.22 Pain Relevance 1.12
To determine whether protection against acetaminophen-induced liver and kidney damage involved ribose cysteine dependent GSH biosynthesis, buthionine sulfoximine was used to selectively block gamma-glutamylcysteine synthetase (gamma-GCS).
Negative_regulation (block) of gamma-glutamylcysteine synthetase in kidney associated with paracetamol
3) Confidence 0.54 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15910414 Disease Relevance 0.22 Pain Relevance 1.12
Buthionine sulphoximine (BSO) is an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS) and, consequently lowers tissue glutathione (GSH) concentrations.
Negative_regulation (inhibitor) of gamma-glutamylcysteine synthetase
4) Confidence 0.41 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6148944 Disease Relevance 0 Pain Relevance 0
Buthionine sulphoximine (BSO) is an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS) and, consequently lowers tissue glutathione (GSH) concentrations.
Negative_regulation (inhibitor) of gamma-GCS
5) Confidence 0.41 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6148944 Disease Relevance 0 Pain Relevance 0
L-2-Oxothiazolidine-4-carboxylate is well transported into many cells and is converted by 5-oxoprolinase to cysteine, a substrate of gamma-glutamylcysteine synthetase. gamma-Glutamylcysteine and related compounds are effectively transported, especially into renal cells, thus providing substrate for glutathione synthetase; higher than normal levels of glutathione can be achieved because this enzyme is not significantly inhibited by glutathione, whereas gamma-glutamylcysteine synthetase is feedback-inhibited.
Negative_regulation (inhibited) of gamma-glutamylcysteine synthetase in L-2
6) Confidence 0.37 Published 1986 Journal J Am Coll Nutr Section Abstract Doc Link 3722629 Disease Relevance 0 Pain Relevance 0.06
Glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferasemu, and glutathione peroxidase 1 were down-regulated in the liver of hepatocyte RXRalpha-deficient mice.
Negative_regulation (down-regulated) of Glutamate-cysteine ligase catalytic subunit in hepatocyte associated with glutamate
7) Confidence 0.36 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.14 Pain Relevance 0.23
Glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferasemu, and glutathione peroxidase 1 were down-regulated in the liver of hepatocyte RXRalpha-deficient mice.
Negative_regulation (down-regulated) of GCLC in hepatocyte associated with glutamate
8) Confidence 0.36 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.14 Pain Relevance 0.23
To determine whether protection against acetaminophen-induced liver and kidney damage involved ribose cysteine dependent GSH biosynthesis, buthionine sulfoximine was used to selectively block gamma-glutamylcysteine synthetase (gamma-GCS).
Negative_regulation (block) of gamma-GCS in liver associated with paracetamol
9) Confidence 0.18 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15910414 Disease Relevance 0.22 Pain Relevance 1.12
To determine whether protection against acetaminophen-induced liver and kidney damage involved ribose cysteine dependent GSH biosynthesis, buthionine sulfoximine was used to selectively block gamma-glutamylcysteine synthetase (gamma-GCS).
Negative_regulation (block) of gamma-glutamylcysteine synthetase in liver associated with paracetamol
10) Confidence 0.18 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15910414 Disease Relevance 0.22 Pain Relevance 1.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox