INT38256

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.58
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chkb)
Anatomy Link Frequency
plasma 4
heart 2
Chkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 2 99.98 Very High Very High Very High
Calcitonin gene-related peptide 48 99.14 Very High Very High Very High
antagonist 7 98.72 Very High Very High Very High
ischemia 6 98.46 Very High Very High Very High
lidocaine 6 97.58 Very High Very High Very High
qutenza 13 97.20 Very High Very High Very High
opioid receptor 1 93.24 High High
agonist 3 88.48 High High
tolerance 1 81.96 Quite High
local anesthetic 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Heat Stress Disorders 18 99.84 Very High Very High Very High
Contracture 2 99.82 Very High Very High Very High
Fever 8 99.70 Very High Very High Very High
Injury 18 99.46 Very High Very High Very High
Cv Unclassified Under Development 8 98.46 Very High Very High Very High
Myocardial Infarction 4 78.08 Quite High
Hypoxia 52 77.84 Quite High
Coronary Heart Disease 1 77.36 Quite High
Reperfusion Injury 4 75.00 Quite High
Rhabdomyolysis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But the contracture and the release of CK were suppressed with the omission of Ca ion.
Negative_regulation (suppressed) of Localization (release) of CK associated with contracture
1) Confidence 0.56 Published 1986 Journal Nippon Seikeigeka Gakkai Zasshi Section Abstract Doc Link 3722966 Disease Relevance 0.27 Pain Relevance 0.07
Postconditioning with three cycles of 1-min ischemia and 1-min reperfusion produced a marked improvement of cardiac function and decreased CK release and infarct size, concomitantly with an increase in the release of CGRP release in coronary effluent.
Negative_regulation (decreased) of Localization (release) of CK associated with ischemia and calcitonin gene-related peptide
2) Confidence 0.44 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18166234 Disease Relevance 0.10 Pain Relevance 0.62
Lidocaine protects against myofilament damage in the Ca(2+)-paradox but not in the O2-paradox and caffeine protocols, even though CK release is inhibited.
Negative_regulation (inhibited) of Localization (release) of CK associated with lidocaine
3) Confidence 0.42 Published 1996 Journal Pathobiology Section Abstract Doc Link 9031331 Disease Relevance 0 Pain Relevance 0.52
Hyperthermia treatment significantly reduced infarct size and CK release concomitantly with a dramatic increase in plasma concentrations of CGRP and the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, which was completely abolished by pretreatment with capsazepine (38 mg/kg, s.c.), a competitive vanilloid receptor 1 antagonist.
Negative_regulation (reduced) of Localization (release) of CK in plasma associated with antagonist, fever and calcitonin gene-related peptide
4) Confidence 0.40 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906841 Disease Relevance 0.49 Pain Relevance 0.44
Pretreatment with hyperthermia significantly reduced infarct size and CK release.
Negative_regulation (reduced) of Localization (release) of CK associated with fever
5) Confidence 0.39 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 12060099 Disease Relevance 0.76 Pain Relevance 0.69
The inactive isomer L-naloxone decreased the CK release by half.
Negative_regulation (decreased) of Localization (release) of CK associated with narcan
6) Confidence 0.38 Published 2000 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 10808507 Disease Relevance 0.07 Pain Relevance 0.58
RESULTS: Capsaicin (50 mg.kg-1, s.c.) improved the recovery of cardiac function and decreased the release of CK.
Negative_regulation (decreased) of Localization (release) of CK
7) Confidence 0.37 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 11270991 Disease Relevance 0 Pain Relevance 0
Retrograde hyperthermic perfusion (42 degrees C) for 5 min improved the recovery of cardiac function, decreased the release of CK and elevated the content of CGRP-LI in the coronary effluent.
Negative_regulation (decreased) of Localization (release) of CK associated with calcitonin gene-related peptide
8) Confidence 0.36 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10431759 Disease Relevance 0.63 Pain Relevance 0.62
Heat stress induced by pretreatment with whole body hyperthermia (rectal 42 degrees C) for 15 min produced a significant increase in the plasma content of CGRP, an improvement of cardiac function and a decrease in the release of CK.
Negative_regulation (decrease) of Localization (release) of CK in plasma associated with heat stress disorders, fever and calcitonin gene-related peptide
9) Confidence 0.27 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10100927 Disease Relevance 0.52 Pain Relevance 0.47
It has been reported that thiopental depresses the release of reactive oxygen species (ROS) from neutrophils12 and inhibits lipid peroxidation as antioxidant properties.13 Thiopental is also primarily known as an anesthetic that protects the brain against I/R injury.14,15 Although thiopental reduces creatine kinase (CK) release, an indicator of cell damage, in isolated ischemic heart muscle16 and restores recovery of heart function at extremely high concentrations in the ischemic rat heart,17 its role in cardioprotection remains a matter of debate.
Negative_regulation (reduces) of Localization (release) of CK in heart associated with injury
10) Confidence 0.08 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.73 Pain Relevance 0.10

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