INT38265

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 10.59
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPL) small molecule metabolic process (LPL) extracellular region (LPL)
plasma membrane (LPL) lipid metabolic process (LPL)
Anatomy Link Frequency
plasma 5
adipose tissue 4
lipid droplets 2
liver 1
monocytes 1
LPL (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 127 99.64 Very High Very High Very High
abdominal pain 7 95.88 Very High Very High Very High
Endocannabinoid 41 90.00 High High
Inflammation 89 77.04 Quite High
antagonist 4 60.32 Quite High
chemokine 3 49.52 Quite Low
cytokine 38 46.76 Quite Low
imagery 10 44.04 Quite Low
Angina 8 37.64 Quite Low
Bile 30 31.28 Quite Low
Disease Link Frequency Relevance Heat
Obesity 628 100.00 Very High Very High Very High
Stress 23 99.24 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

13 98.44 Very High Very High Very High
Congenital Anomalies 4 98.20 Very High Very High Very High
Xanthomatosis 2 98.16 Very High Very High Very High
Disease 54 97.64 Very High Very High Very High
Pancreatitis 13 96.68 Very High Very High Very High
Abdominal Pain 7 95.88 Very High Very High Very High
Disorder Of Lipid Metabolism 70 94.80 High High
Hyperlipidemia 44 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite an absolute deficiency of LPL mass and activity demonstrated by analysis of patient post-heparin plasma, in vitro expression of both LPL mutants was normal, suggesting that the absence of LPL in patient post-heparin plasma was a result of altered in vivo processing.
Gene_expression (expression) of LPL in plasma
1) Confidence 0.78 Published 1996 Journal J. Lipid Res. Section Abstract Doc Link 8728326 Disease Relevance 0.15 Pain Relevance 0.05
However, efficacy was transient, because of an anti-hLPL immune response blunting LPL expression.
Gene_expression (expression) of LPL
2) Confidence 0.75 Published 2006 Journal Hum. Gene Ther. Section Abstract Doc Link 16716106 Disease Relevance 0.13 Pain Relevance 0
The lack of functional LPL in patients with LPL deficiency causes an accumulation of triglyceride (TG)-rich lipoproteins in the plasma.
Gene_expression (deficiency) of LPL in plasma
3) Confidence 0.67 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.54 Pain Relevance 0.10
The first clinical trials in patients with LPL deficiency appear promising, with a significant decrease in the levels of plasma TGs observed in the first 3 months following the administration of alipogene tiparvovec, and an increase in local LPL activity and protein levels observed after 6 months.
Gene_expression (deficiency) of LPL in plasma
4) Confidence 0.67 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.58 Pain Relevance 0.08
Apropos of 2 cases].
Gene_expression (Apropos) of Lipoprotein lipase
5) Confidence 0.65 Published 1986 Journal Pediatrie Section Title Doc Link 3725507 Disease Relevance 0.27 Pain Relevance 0.09
By varying the dose per site, linear LPL expression was demonstrated over a wide range of local doses (4 x 10(10)-1 x 10(12) GC/site).
Gene_expression (expression) of LPL
6) Confidence 0.58 Published 2006 Journal Hum. Gene Ther. Section Abstract Doc Link 16716106 Disease Relevance 0.24 Pain Relevance 0.05
Morphological changes in BM-MPCs and T-MPCs and the formation of cytoplasmic lipid droplets were noticeable as early as 1 week of adipogenic induction, as visualized by Oil red O staining (Figure 3a). mRNA expression of LPL and PPAR?
Gene_expression (expression) of LPL in lipid droplets
7) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.05 Pain Relevance 0
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Gene_expression (p85aPI3K) of LPL
8) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0
This SNP has been also associated to altered plasma levels of LPL, leptin, adiponectin, and resistin.
Gene_expression (levels) of LPL in plasma
9) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.31 Pain Relevance 0
Some cells were partially able to overcome the effects of ouabain depolarization at later time points, as seen by their ability to increase LPL expression and form lipid droplets.


Gene_expression (expression) of LPL in lipid droplets
10) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
On all days, however, LPL expression in AD-ouab cells, while lower than that of untreated AD cells, was greater than that of AD-80K cells (34.0-, 7.0-, 5.2-, and 13.5-fold greater for Days 2, 7, 14, and 22, respectively, p<0.0005, Fig. 3).
Gene_expression (expression) of LPL
11) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Exposure to 10 nM ouabain for two days did not significantly change PPARG or LPL expression (Fig. 5A), but a four-day exposure resulted in a 2.5-fold decrease in PPARG and 3.7-fold decrease in LPL expression (Fig. 5B, p<0.02) compared to untreated AD.
Gene_expression (expression) of LPL
12) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
On Days 2, 7, and 14, samples treated with 80 mM K+ (denoted AD-80K) had significantly lower LPL expression compared to untreated AD samples (decrease of 50.7-fold, 219.7-fold, and 43.5-fold, respectively, p<0.007, Fig. 3).
Gene_expression (expression) of LPL
13) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Exposure to 10 nM ouabain for two days did not significantly change PPARG or LPL expression (Fig. 5A), but a four-day exposure resulted in a 2.5-fold decrease in PPARG and 3.7-fold decrease in LPL expression (Fig. 5B, p<0.02) compared to untreated AD.
Gene_expression (expression) of LPL
14) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Lipoprotein lipase was markedly expressed in adipogenic cultured cells (Figure 2a).
Gene_expression (expressed) of Lipoprotein lipase
15) Confidence 0.21 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.21 Pain Relevance 0
Expression of Lpl in liver is restricted to Kupffer cells and upregulated by PPAR?
Gene_expression (Expression) of Lpl in liver
16) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.33 Pain Relevance 0.19
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Gene_expression (cause) of LPL in Adipose tissue associated with obesity
17) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.84 Pain Relevance 0
Fibrates work by lowering hepatic apoC-III production and increasing lipoprotein lipase that will results in a decrease in VLDL production [10].
Gene_expression (production) of lipoprotein lipase
18) Confidence 0.18 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1963453 Disease Relevance 1.24 Pain Relevance 0
However, it remains to be elucidated whether an impaired adipose tissue LPL activity during ?
Spec (whether) Gene_expression (activity) of LPL in adipose tissue associated with obesity
19) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.72 Pain Relevance 0
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Gene_expression (cause) of tissue lipoprotein lipase in Adipose tissue associated with obesity
20) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.85 Pain Relevance 0

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