INT38266

Context Info Confidence 0.68 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 30 Total Number 30 Disease Relevance 17.05 Pain Relevance 1.68

plasma membrane (PTPRC)

Anatomy Link Frequency eustachian tube 2 urine 2 bone tissue 2 middle ear 1 neural crest 1 PTPRC (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 1 98.72 Inflammation 705 97.04 Neuropathic pain 1 96.12 rheumatoid arthritis 7 95.20 Inflammatory mediators 144 92.96 cytokine 421 89.00 Pain 15 87.12 Inflammatory response 76 86.68 interstitial cystitis 3 85.20 ischemia 2 84.96

Disease Link Frequency Relevance Heat Dengue 15 100.00 Cancer 354 99.84 Colon Cancer 24 99.76 Skin Cancer 3 99.60 Ovarian Cancer 46 99.58 Otitis Media 804 99.12 Obesity 7 99.12 Breast Cancer 86 98.88 Asthma 198 97.80 Stress 49 97.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An analysis is presented of a comparative study of the Delta T and Copper T 200 IUDs.

Localization (presented) of T 200

1) Confidence 0.68 Published 1986 Journal Acta Eur. Fertil. Section Abstract Doc Link 3727892 Disease Relevance 0.38 Pain Relevance 0.15

An analysis is presented of a study of the Copper-T 200 (CuT 200) intrauterine device at the Barros Luco Hospital in Santiago, Chile.

Localization (presented) of T 200

2) Confidence 0.68 Published 1983 Journal Int J Gynaecol Obstet Section Abstract Doc Link 6133798 Disease Relevance 0 Pain Relevance 0

These cells were distinct from the hematopoietic lineage as CD11b, CD14, and CD45 mRNA were not expressed.

Localization (lineage) of CD45

3) Confidence 0.32 Published 2008 Journal Stem Cells Section Abstract Doc Link 18583536 Disease Relevance 0.31 Pain Relevance 0.16

The presence of CD3+ and CD45+ cells was used as an indicator of T cell infiltration and the prevalence of CD4+, CD8+, CD56+ cells as indicators of T helper, T cytotoxic and NK cells, respectively and CD1a was used as a marker for antigen presenting cells (APC).

Localization (presence) of CD45 in T cell

4) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 1.02 Pain Relevance 0

This glycoprotein is produced and secreted by the transitional epithelium of the genitourinary tract, and has been isolated from human urine.

Localization (secreted) of glycoprotein in urine

5) Confidence 0.10 Published 1999 Journal J. Urol. Section Abstract Doc Link 10332435 Disease Relevance 0.16 Pain Relevance 0.24

A cross tabulation of the empiric classification and LCA classification is presented in Table 2.

Localization (presented) of LCA

6) Confidence 0.08 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.65 Pain Relevance 0

Similarly, the concentrations of MUC-1, a progesterone-dependent glycoprotein secreted by the glands, are lower at day LH + 10 in women suffering recurrent spontaneous miscarriage than in fertile controls [55].

Localization (secreted) of glycoprotein in glands associated with reprotox - general 1

7) Confidence 0.07 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.25 Pain Relevance 0.03

Quantitatively, the major glandular product detected in maternal serum is a dimeric glycoprotein that is now referred to as glycodelin A, but has been termed PP14 and ?

Localization (referred) of glycoprotein

8) Confidence 0.07 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0

Ulinastatin (Ulistin®, Han Lim Pharmaceutical, Seoul, Korea), a urinary trypsin inhibitor, is a glycoprotein derived from human urine [12].

Localization (derived) of glycoprotein in urine

9) Confidence 0.07 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.84 Pain Relevance 0.27

Mucin 6 is a secreted glycoprotein that forms a protective gel layer around the producing cell [58].

Localization (secreted) of glycoprotein

10) Confidence 0.03 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 1.28 Pain Relevance 0

Clusterin is a secreted heterodimeric 70-80 kDa glycoprotein composed of alpha and beta chains linked by five inter-chain disulfide bonds [4,5].

Localization (secreted) of glycoprotein

11) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.70 Pain Relevance 0

Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival.

Localization (secreted) of glycoprotein associated with stress

12) Confidence 0.02 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2856549 Disease Relevance 0.62 Pain Relevance 0

The observation that clusterin over-expression also stimulates invasion and metastatic progression, at least to the lungs, suggests that the secreted glycoprotein has additional extracellular functions.

Localization (secreted) of glycoprotein in lungs

13) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.43 Pain Relevance 0

BSP is a secreted glycoprotein mainly localized to the extracellular matrix of bone tissue [39].

Localization (localized) of glycoprotein in bone tissue

14) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0.09 Pain Relevance 0

BSP is a secreted glycoprotein mainly localized to the extracellular matrix of bone tissue [39].

Localization (secreted) of glycoprotein in bone tissue

15) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0.09 Pain Relevance 0

Glycans were released from approximately 25ug of recombinant soluble dengue virus E-glycoprotein and labelled by reductive amination with the fluorophore 2-aminobenzamide [39,40].

Localization (released) of glycoprotein associated with dengue

16) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.18 Pain Relevance 0

Fibulin-1 (FBLN-1), a secreted glycoprotein, assists in stabilizing the ECM.

Localization (secreted) of glycoprotein

17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.57 Pain Relevance 0.04

However, the expression and function of fibulin-1, a secreted glycoprotein which interacts with fibronectin, has not been reported.

Localization (secreted) of glycoprotein

18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954173 Disease Relevance 0.32 Pain Relevance 0

A commonly followed biomarker in ovarian cancer trials is CA-125, a glycoprotein secreted by cancer cells.36 The relationship between the efficacy of PLD and CA-125 concentration changes has been extensively explored.

Localization (secreted) of glycoprotein associated with cancer and ovarian cancer

19) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731020 Disease Relevance 0.67 Pain Relevance 0

Sclerostin, a glycoprotein secreted by osteocytes and to a lesser extent other cell types (vascular, kidney), is a potent inhibitor of osteoblastogenesis.

Localization (secreted) of glycoprotein in kidney

20) Confidence 0.01 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0 Pain Relevance 0

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