INT38268

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Context Info
Confidence 0.17
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.54
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BEST1) plasma membrane (BEST1)
Anatomy Link Frequency
coronary artery 2
joints 1
vesicles 1
pallidum 1
BEST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 99.92 Very High Very High Very High
Angina 38 99.90 Very High Very High Very High
Inflammation 44 98.02 Very High Very High Very High
rheumatoid arthritis 109 96.96 Very High Very High Very High
Pain 26 94.88 High High
imagery 36 91.20 High High
abatacept 138 58.16 Quite High
cINOD 4 42.80 Quite Low
c fibre 1 33.20 Quite Low
withdrawal 6 28.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 331 100.00 Very High Very High Very High
Coronary Artery Disease 17 100.00 Very High Very High Very High
Pulmonary Disease 11 100.00 Very High Very High Very High
Skin Diseases 10 100.00 Very High Very High Very High
Cv Unclassified Under Development 1 99.92 Very High Very High Very High
Worm Infection 26 99.90 Very High Very High Very High
Cv General 3 Under Development 23 99.90 Very High Very High Very High
Treponema Pallidum Infection 8 99.78 Very High Very High Very High
Rupture 1 99.02 Very High Very High Very High
Enteritis 2 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a structured worksheet, the BestPROMPT copy that was generated during this exercise was used in the second part of the usability session to elicit feedback on format (e.g., font, spacing), readability, and understandability using a five-point Likert scale.
Positive_regulation (generated) of BestPROMPT
1) Confidence 0.17 Published 2010 Journal Implement Sci Section Body Doc Link PMC3016442 Disease Relevance 0.23 Pain Relevance 0
Median levels of the bone markers were not elevated (compared with the reference values) in spite of active disease.
Neg (not) Positive_regulation (elevated) of disease associated with disease
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 1.23 Pain Relevance 0.15
Briefly, these patients had a diagnosis of RA according to the American College of Rheumatology criteria [23], were between 18 and 80 years of age, had a disease duration of less than one year and had active disease defined as a Disease Activity Score of 28 joints (DAS28) of more than 3.0.
Positive_regulation (had) of disease in joints associated with rheumatoid arthritis and disease
3) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.76 Pain Relevance 0.20
Because acute inflammation may play a role in coronary artery plaque rupture, it was hypothesized that NF-kappaB activation correlated with coronary artery disease (CAD) activity.
Spec (hypothesized) Positive_regulation (activation) of disease in coronary artery associated with coronary artery disease, inflammation and rupture
4) Confidence 0.02 Published 1998 Journal Circulation Section Abstract Doc Link 9788823 Disease Relevance 0.83 Pain Relevance 0.20
The increases in aBMD in the two groups were similar to those previously observed [21–23].
Positive_regulation (increases) of aBMD
5) Confidence 0.01 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0 Pain Relevance 0
The result of this perturbation is a net rapid increase in aBMD with alendronate [10].
Positive_regulation (increase) of aBMD
6) Confidence 0.01 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0.18 Pain Relevance 0
Defining these changes is important because only a small proportion of the fracture risk reduction with antiresorptives is accounted for by the increase in aBMD.
Positive_regulation (increase) of aBMD
7) Confidence 0.01 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0.24 Pain Relevance 0
Yaws

Yaws is a skin disease caused by Treponema pallidum, subspecies pertennae, and Africa has the highest concentration of the disease [135].

Positive_regulation (caused) of disease in pallidum associated with skin diseases, treponema pallidum infection and disease
8) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.82 Pain Relevance 0
In addition, based on revised estimates for schistosomiasis that fully consider the morbidities of chronic infection including effects on anemia, malnutrition, growth stunting, and diminished child development [22],[23], and the observation that many of these same sequelae occur for STH and other helminth infections [4], [5], [50], [51], [57]–[61], the possibility remains that maternal and child helminthiases may increase even further in their disease control priority rankings.
Positive_regulation (increase) of disease associated with appetite loss, anaemia, worm infection, disease, infection and schistosomiasis
9) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.53 Pain Relevance 0
This may have induced an artificial disease flare that could account for the high baseline disease activity and could potentially also lead to a high placebo response rate.
Positive_regulation (induced) of disease associated with disease
10) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936358 Disease Relevance 0.68 Pain Relevance 0.26
This may have induced an artificial disease flare that could account for the high baseline disease activity and could potentially also lead to a high placebo response rate.
Positive_regulation (account) of disease associated with disease
11) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936358 Disease Relevance 0.67 Pain Relevance 0.25
Children with comorbidities are at increased risk of severe H1N1 disease, and for this reason we did not exclude children with pre-existing medical conditions (except immunodeficiency), making our findings particularly relevant to the general paediatric population.
Positive_regulation (increased) of disease associated with disease and immunodeficiency
12) Confidence 0.00 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2877808 Disease Relevance 0.49 Pain Relevance 0
Pacing-induced angina pectoris and induction of ventricular arrhythmias in coronary artery disease.
Positive_regulation (induction) of disease in coronary artery associated with angina and coronary artery disease
13) Confidence 0.00 Published 1986 Journal Am. J. Cardiol. Section Title Doc Link 3728338 Disease Relevance 0.87 Pain Relevance 0.32
They show that the earliest manifestation of chronic obstructive pulmonary disease (COPD) is an increase in residual volume suggesting that the natural history of COPD is a progressive increase in gas trapping with a decreasing vital capacity (VC).
Positive_regulation (increase) of disease associated with pulmonary disease
14) Confidence 0.00 Published 2010 Journal Eur. Respir. J. Section Abstract Doc Link 20190332 Disease Relevance 0.44 Pain Relevance 0
This increase is unlikely to be related to an increase in underlying disease prevalence, since the rate of hospitalization for AMI in the same population has been nearly constant [37,38].
Positive_regulation (increase) of disease associated with disease and myocardial infarction
15) Confidence 0.00 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2435520 Disease Relevance 0.93 Pain Relevance 0.20
We conclude that the antiphospholipid antibody IgG-PS may contribute to coagulation activation in HbSS disease and that IgG-PS, protein C, and protein S relate to each other and jointly to measures of coagulation activation.
Positive_regulation (activation) of HbSS disease associated with disease
16) Confidence 0.00 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10521081 Disease Relevance 0.85 Pain Relevance 0.20
The increased level of IgG-PS in HbSS disease most likely reflects exposure of the procoagulant phosphatidylserine on the surfaces of red cell-shed vesicles and sickle red cells, which would further affect coagulation activation.
Positive_regulation (increased) of HbSS disease in vesicles associated with disease
17) Confidence 0.00 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10521081 Disease Relevance 0.80 Pain Relevance 0.16

General Comments

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