INT38276

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 9.26
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
plasma 2
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
visual analogue scale 5 98.58 Very High Very High Very High
chemokine 289 98.52 Very High Very High Very High
rheumatoid arthritis 135 97.82 Very High Very High Very High
Inflammation 151 97.52 Very High Very High Very High
Arthritis 103 94.24 High High
lidocaine 7 88.72 High High
depression 1 82.72 Quite High
cytokine 42 78.24 Quite High
antagonist 23 71.36 Quite High
psoriasis 3 50.56 Quite High
Disease Link Frequency Relevance Heat
Infection 211 100.00 Very High Very High Very High
Syndrome 18 100.00 Very High Very High Very High
Severe Acute Respiratory Syndrome 3 99.60 Very High Very High Very High
Viral Meningitis 6 98.64 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 20 98.48 Very High Very High Very High
Pulmonary Disease 107 98.40 Very High Very High Very High
Rheumatoid Arthritis 135 97.82 Very High Very High Very High
INFLAMMATION 147 97.52 Very High Very High Very High
Viral Infection 6 97.48 Very High Very High Very High
Systemic Lupus Erythematosus 39 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variable selection by multiple linear regression analysis of the six SSEP measurements gave a statistical model that sensory block duration (SVAS greater than or equal to 8) could be specified by the duration of the reduced C-7 amplitude (r = 0.96).
Negative_regulation (reduced) of C-7 associated with visual analogue scale
1) Confidence 0.42 Published 1986 Journal Anesth. Analg. Section Abstract Doc Link 3729020 Disease Relevance 0.08 Pain Relevance 0.65
RESULTS: There was excellent visualization of the C-3, C-4, C-5, C-6 and C-7 transverse processes in all cases.
Negative_regulation (visualization) of C-7
2) Confidence 0.41 Published 2010 Journal Surg Radiol Anat Section Body Doc Link 20082079 Disease Relevance 0 Pain Relevance 0
, CXCL10 (IP-10) and CCL5 (RANTES) were measured in plasma and paired SF (prepared by identical method) from a subset of 14 of the patients (4 persistent oligoarticular, 6 extended oligoarticular, 4 polyarticular JIA), and in plasma from 14 healthy control children.
Negative_regulation (paired) of IP-10 in plasma associated with arthritis
3) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.51 Pain Relevance 0.34
, CXCL10 (IP-10) and CCL5 (RANTES) were measured in plasma and paired SF (prepared by identical method) from a subset of 14 of the patients (4 persistent oligoarticular, 6 extended oligoarticular, 4 polyarticular JIA), and in plasma from 14 healthy control children.
Negative_regulation (paired) of CXCL10 in plasma associated with arthritis
4) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.51 Pain Relevance 0.34
In both sera from the different patient groups and from healthy controls only low levels of CXCL10 were detectable (about 200 pg/ml; Fig. 9).
Negative_regulation (levels) of CXCL10
5) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.30 Pain Relevance 0.31
SF PMN from patients with RA exhibit a characteristic chemokine expression pattern resembling the upregulation of CCL3, CCL18, CXCL8 and CXCL10 mRNAs and the downregulation of CCL21 mRNA.
Negative_regulation (downregulation) of CXCL10 associated with chemokine and rheumatoid arthritis
6) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.79 Pain Relevance 0.45
In SARS patients, elevated IP-10 early in infection was shown to be a predictor for a more severe outcome [34].
Negative_regulation (predictor) of IP-10 associated with severe acute respiratory syndrome and infection
7) Confidence 0.12 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.13 Pain Relevance 0.24
B could all induce the production of IP-10 and I-TAC, prevention of IP-10 and I-TAC via NF-?
Negative_regulation (prevention) of IP-10
8) Confidence 0.12 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.21 Pain Relevance 0.09
B inhibition clearly reduced the IP-10 level in HepG2 cells.
Negative_regulation (reduced) of IP-10
9) Confidence 0.12 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.25 Pain Relevance 0.09
These data implicate MCP-1 and IP-10 in the pathogenesis of GBS, and IP-10 and MIP-3beta in the pathogenesis of CIDP.
Spec (implicate) Negative_regulation (implicate) of IP-10 associated with chronic inflammatory demyelinating polyradiculoneuropathy and syndrome
10) Confidence 0.07 Published 2003 Journal J. Clin. Immunol. Section Abstract Doc Link 12959218 Disease Relevance 1.22 Pain Relevance 0.16
These data implicate MCP-1 and IP-10 in the pathogenesis of GBS, and IP-10 and MIP-3beta in the pathogenesis of CIDP.
Spec (implicate) Negative_regulation (implicate) of IP-10 associated with chronic inflammatory demyelinating polyradiculoneuropathy and syndrome
11) Confidence 0.07 Published 2003 Journal J. Clin. Immunol. Section Abstract Doc Link 12959218 Disease Relevance 1.22 Pain Relevance 0.16
Specific inhibitors of CXCL10/CXCR3 interaction might therefore be useful for COPD treatment.
Negative_regulation (inhibitors) of CXCL10 associated with pulmonary disease
12) Confidence 0.05 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.03 Pain Relevance 0.35

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