INT38292

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (COX1) mitochondrion (COX1) oxidoreductase activity (COX1)
aging (COX1) molecular_function (COX1)
COX1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
licofelone 4 99.82 Very High Very High Very High
Hyperalgesia 6 97.84 Very High Very High Very High
allodynia 4 96.96 Very High Very High Very High
Pain 6 95.32 Very High Very High Very High
Potency 1 51.52 Quite High
Perioperative pain 2 30.88 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 98.58 Very High Very High Very High
Hyperalgesia 6 97.84 Very High Very High Very High
Neuropathic Pain 4 96.96 Very High Very High Very High
Pain 6 95.32 Very High Very High Very High
Post Operative Pain 2 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was aimed to examine the effect of licofelone, a dual inhibitor of cyclooxygenases (COX-1/COX-2) and 5-lipoxygenase (5-LOX) against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain.
Negative_regulation (inhibitor) of COX-1 associated with pain, hyperalgesia, allodynia and licofelone
1) Confidence 0.41 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 15985722 Disease Relevance 1.00 Pain Relevance 1.27
A combined deficiency of Apo C-I and C-II assessed by mono and bidimensional electrophoresis as well as immunoelectrophoresis is described.
Negative_regulation (deficiency) of C-I
2) Confidence 0.01 Published 1986 Journal Clin. Chim. Acta Section Abstract Doc Link 3731486 Disease Relevance 0.21 Pain Relevance 0.08
HDL3 predominance in decreased HDL fraction and strongly decreased CE/TC ratio could be dependent of Apo C-I deficiency.
Negative_regulation (deficiency) of C-I associated with disorder of lipid metabolism
3) Confidence 0.01 Published 1986 Journal Clin. Chim. Acta Section Abstract Doc Link 3731486 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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