INT38303

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 15.84
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
plasma 3
Blood 1
hepatocytes 1
liver 1
body 1
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
diclofenac 3 99.66 Very High Very High Very High
Paracetamol 131 99.04 Very High Very High Very High
cINOD 30 97.70 Very High Very High Very High
imagery 27 96.96 Very High Very High Very High
fibrosis 104 96.72 Very High Very High Very High
depression 14 94.00 High High
headache 6 93.04 High High
Migraine 1 92.64 High High
Arthritis 24 92.16 High High
Disease Link Frequency Relevance Heat
Obesity 47 100.00 Very High Very High Very High
Hepatotoxicity 58 99.80 Very High Very High Very High
Congenital Anomalies 7 99.64 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 15 99.56 Very High Very High Very High
Hepatitis C Virus Infection 111 99.54 Very High Very High Very High
Hepatitis B Virus Infection 116 99.52 Very High Very High Very High
Hepatocellular Cancer 89 99.14 Very High Very High Very High
Toxicity 54 99.00 Very High Very High Very High
Pressure And Volume Under Development 9 98.96 Very High Very High Very High
Pleural Effusion 5 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, these hotspots induced by particles occurred at G or C residues in the gpt gene without association for specific sequences.


gpt gene Binding (association) of
1) Confidence 0.47 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.10 Pain Relevance 0
Traditional in vivo methods using smaller mammals are mechanistically restrictive in that measures of hepatotoxicity, such as plasma glutamic-pyruvic transaminase (GPT), and chemical covalent binding to hepatocellular protein are performed at different times in separate groups of animals.
plasma glutamic-pyruvic transaminase Binding (binding) of in plasma associated with hepatotoxicity
2) Confidence 0.40 Published 1986 Journal Fundam Appl Toxicol Section Abstract Doc Link 3732668 Disease Relevance 0.43 Pain Relevance 0.38
On the other hand, when acetaminophen at the same dose was injected in ICR mice, the activity of plasma GPT was increased by 9-fold at 6 h, or 16-fold at 24 h after the drug injection.
GPT Binding (activity) of in plasma associated with paracetamol
3) Confidence 0.37 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8553366 Disease Relevance 0.48 Pain Relevance 0.51
This suggests that ALT, AST and BUN may be valid early indicators for monitoring emerging toxicity in patients undergoing treatment with sunitinib and paracetamol.


ALT Binding (indicators) of associated with toxicity and paracetamol
4) Confidence 0.33 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.60 Pain Relevance 0.40
A better association between ALT and steatosis versus GGT and steatosis has also been observed using proton magnetic resonance imaging [32].
ALT Binding (association) of associated with imagery
5) Confidence 0.22 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.54 Pain Relevance 0.07
However, the incidence rate for lumiracoxib 100 mg o.d. is similar to that reported in the prescribing information for many NSAIDs (1% or less), such as naproxen and ibuprofen [33,34], and less than that observed with diclofenac, which has been associated with ALT and AST abnormalities in 3.2% and 1.8% of patients, respectively [35].
ALT Binding (associated) of associated with congenital anomalies, cinod and diclofenac
6) Confidence 0.19 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2322990 Disease Relevance 0.26 Pain Relevance 0.34
Loguercio et al. [31] observed that in 305 patients with abnormal GGT or ALT, age, ferritin and tissue 4-hydroxynonenal were associated with steatosis.
ALT Binding (associated) of
7) Confidence 0.17 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.86 Pain Relevance 0
In the training group the most significant components associated with the presence of grade 2–4 steatosis in univariate analysis were body mass index (BMI), age, ALT, aspartate aminotransferase (AST), GGT, glucose, and triglycerides.
ALT Binding (associated) of in body associated with obesity
8) Confidence 0.17 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.99 Pain Relevance 0.04
Efficacy was measured at the end of therapy and after follow-up by normalization of alanine aminotransferase (ALT), improvement in liver histology, reduction in hepatitis C virus (HCV) RNA level and improvement of symptoms.
ALT Binding (normalization) of in liver associated with hepatitis c virus infection and hepatitis
9) Confidence 0.10 Published 1997 Journal Hepatology Section Abstract Doc Link 9252161 Disease Relevance 0.75 Pain Relevance 0.04
In the remaining 14 non-HCC patients, judging by their annual average ALT pattern, maintaining ALT below ?
ALT Binding (pattern) of associated with hepatocellular cancer
10) Confidence 0.07 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.52 Pain Relevance 0.08
The patient responded well to therapy, with AST and ALT declining to 145 and 479 U/L respectively over the next 48 hours.
ALT Binding (declining) of
11) Confidence 0.05 Published 2009 Journal Semin Diagn Pathol Section Abstract Doc Link 19292023 Disease Relevance 0.49 Pain Relevance 0.53
Two other studies considered the association between ALT measures and quality of life [10,15], and did not find an association, as we did.
ALT Binding (association) of
12) Confidence 0.04 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.46 Pain Relevance 0.40
As shown in Figure 2, both showed rapid improvement of serum ALT and PT-INR after hospitalization, without any particular support.
serum ALT Binding (improvement) of
13) Confidence 0.04 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2527551 Disease Relevance 0.59 Pain Relevance 0
As we all know, liver Injury after ethanol treatment is a common phenomenon, and the obvious indicator of liver injury is the leakage of cellular enzymes into plasma.[51] The increase in serum enzymes levels associated with ALT and AST has been observed in ethanol-treated rats, which shows the enhanced permeability, injury and necrosis of hepatocytes.[52] The hepatoprotective effect of quercetin on liver injury is well evident, which significantly inhibits the increases in these enzymes levels caused by ethanol for keeping the liver structural integrity from ethanol injury.
ALT Binding (associated) of in hepatocytes associated with necrosis and injury
14) Confidence 0.03 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900062 Disease Relevance 1.25 Pain Relevance 0.08
This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian.
serum glutamate pyruvate transaminase Spec (examination) Binding (comparing) of associated with glutamate
15) Confidence 0.03 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 8030617 Disease Relevance 0.16 Pain Relevance 0.19
We measured the activities of ALT, AST and ALP before starting the treatment (as baseline values) and after the treatment of rats with the drugs.
ALT Binding (activities) of
16) Confidence 0.03 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2491620 Disease Relevance 0.19 Pain Relevance 0
In the present experiment, ALT activity tended to be lower in the ?
ALT Binding (activity) of
17) Confidence 0.03 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.65 Pain Relevance 0.05
In addition to HBV genotype, lower HBV DNA levels, and higher ALT levels, female sex, older age, and no prior treatment with IFN were also recognized as significant predictors of response at baseline.
ALT Binding (recognized) of associated with hepatitis b virus infection
18) Confidence 0.02 Published 2010 Journal Curr Hepat Rep Section Body Doc Link PMC2861769 Disease Relevance 0.63 Pain Relevance 0
Those who are inactive carriers (HBeAg-negative with < 105 copies/mL of HBV DNA and normal ALTs) do not need treatment, but should have periodic monitoring of ALT, aspartate aminotransferase (AST), and HBV DNA.
ALT Binding (monitoring) of associated with hepatitis b virus infection
19) Confidence 0.02 Published 2005 Journal J Int AIDS Soc Section Body Doc Link PMC2740790 Disease Relevance 1.65 Pain Relevance 0.04
Blood tests, including albumin, bilirubin, alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST) were performed prior to and at 24 and 48 hours following SIRT in the majority of patients.
ALT Binding (albumin) of in Blood
20) Confidence 0.02 Published 2005 Journal BMC Nucl Med Section Body Doc Link PMC1360059 Disease Relevance 0.40 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox