INT38306

Context Info Confidence 0.01 First Reported 1986 Last Reported 1986 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.42 Pain Relevance 0.39

transferase activity, transferring glycosyl groups (Dpagt1) endoplasmic reticulum (Dpagt1) nucleus (DACT1) cytoplasm (DACT1)

Anatomy Link Frequency plasma 1 Dpagt1 (Mus musculus) DACT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 6 85.76 anesthesia 1 75.92

Disease Link Frequency Relevance Heat Hepatotoxicity 6 99.04 Death 1 93.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Traditional in vivo methods using smaller mammals are mechanistically restrictive in that measures of hepatotoxicity, such as plasma glutamic-pyruvic transaminase (GPT), and chemical covalent binding to hepatocellular protein are performed at different times in separate groups of animals.

GPT Binding (binding) of hepatocellular protein in plasma associated with hepatotoxicity

1) Confidence 0.01 Published 1986 Journal Fundam Appl Toxicol Section Abstract Doc Link 3732668 Disease Relevance 0.42 Pain Relevance 0.39

General Comments

This test has worked.