INT3831

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Context Info
Confidence 0.28
First Reported 1977
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.99
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TGFBR2)
Anatomy Link Frequency
lung 2
TGFBR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 97.16 Very High Very High Very High
calcitonin gene related peptide 2 39.84 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 124 99.64 Very High Very High Very High
Squamous Cell Carcinoma 122 99.36 Very High Very High Very High
Nociception 8 97.52 Very High Very High Very High
Cancer 124 97.16 Very High Very High Very High
Pain 8 97.16 Very High Very High Very High
Uterine Fibroids 144 96.40 Very High Very High Very High
Apoptosis 18 74.56 Quite High
Lung Cancer 112 33.72 Quite Low
Disease 18 11.88 Low Low
Rheumatoid Arthritis 46 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the 11 datasets, majority of them show that BMP7 is up-regulated and TGFBR2/FOS are down-regulated in both AD and SCC compared to normal lung, whereas between AD and SCC, BMP7 has an opposite expression pattern to TGFBR2/FOS (Figure 5).
Negative_regulation (down) of TGFBR2 in lung associated with squamous cell carcinoma and adenocarcinoma
1) Confidence 0.28 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.16 Pain Relevance 0
Among the 11 datasets, majority of them show that BMP7 is up-regulated and TGFBR2/FOS are down-regulated in both AD and SCC compared to normal lung, whereas between AD and SCC, BMP7 has an opposite expression pattern to TGFBR2/FOS (Figure 5).
Negative_regulation (regulated) of TGFBR2 in lung associated with squamous cell carcinoma and adenocarcinoma
2) Confidence 0.28 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.16 Pain Relevance 0
due to a reduction or absence of the type II receptor (TGF-?
Negative_regulation (reduction) of type II receptor
3) Confidence 0.23 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.77 Pain Relevance 0
due to a reduction or absence of the type II receptor (TGF-?
Negative_regulation (absence) of type II receptor
4) Confidence 0.23 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.77 Pain Relevance 0
In this case, a decrease of the RII reflex was observed in BF, together with an increase of both RIII and pain sensation.
Negative_regulation (decrease) of RII associated with nociception and pain
5) Confidence 0.11 Published 1977 Journal Pain Section Abstract Doc Link 876668 Disease Relevance 1.13 Pain Relevance 0.55

General Comments

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