INT38312

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Context Info
Confidence 0.07
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
hippocampus 2
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.54 Very High Very High Very High
Morphine 8 97.80 Very High Very High Very High
medulla 2 86.24 High High
tetrodotoxin 1 86.08 High High
Opioid 3 84.64 Quite High
addiction 4 84.08 Quite High
drug abuse 1 67.92 Quite High
antagonist 1 48.64 Quite Low
Disease Link Frequency Relevance Heat
Opiate Addiction 2 84.64 Quite High
Drug Dependence 1 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of NE (10(-8) to 10(-6) M) at the plateau of contraction produced by K+ (22.8 mM), histamine (10(-6) M) or acetylcholine (5 X 10(-8) M) produced a further phentolamine-sensitive contraction which was potentiated by beta adrenoceptor blockade with propranolol (10(-5) M).
Positive_regulation (potentiated) of Gene_expression (blockade) of adrenoceptor
1) Confidence 0.07 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3735137 Disease Relevance 0 Pain Relevance 0.09
Chronic (but not acute) morphine downregulated mRNA levels of alpha(2A)- and alpha(2C)-adrenoceptors in the hippocampus, while simultaneously increased the expression of the alpha(2B)-adrenoceptor gene.
Positive_regulation (increased) of Gene_expression (expression) of adrenoceptor gene in hippocampus associated with hippocampus and morphine
2) Confidence 0.01 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.22 Pain Relevance 1.25

General Comments

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