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Context Info
Confidence 0.35
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.60
Pain Relevance 1.75

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signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
plasma 2
liver 1
uterine 1
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 3 99.40 Very High Very High Very High
Analgesic 1 97.40 Very High Very High Very High
Clonidine 2 97.00 Very High Very High Very High
Dismenorea 1 95.32 Very High Very High Very High
antagonist 8 94.04 High High
Fibrositis 14 93.72 High High
agonist 64 93.36 High High
rheumatoid arthritis 77 93.20 High High
anesthesia 4 87.72 High High
local anesthetic 1 86.24 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 99.84 Very High Very High Very High
Disease 132 97.56 Very High Very High Very High
Desmoid Disease 2 96.92 Very High Very High Very High
Dysmenorrhea 1 95.32 Very High Very High Very High
Fibromyalgia 13 93.72 High High
Rheumatoid Arthritis 77 93.20 High High
Syndrome 3 89.76 High High
Fatigue 2 82.04 Quite High
Pain 5 81.60 Quite High
Obesity 14 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevation of plasma IGFBP-1 immunoreactivity was associated with reduced concentrations of glucose and insulin, the regulators of IGFBP-1 in humans and rats.
Regulation (regulators) of IGFBP-1 in plasma
1) Confidence 0.35 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7520930 Disease Relevance 0 Pain Relevance 0.03
Finally, IGF and IGFBP levels are consistently dysregulated in diabetes,76–79 a metabolic condition frequently linked to DD predisposition.6,80,81 How all these findings will translate into clinical treatment is as yet unclear, but delineation of the abnormal molecular pathophysiology of DD is necessary to design rational molecular treatment methods.
Regulation (dysregulated) of IGFBP associated with diabetes mellitus and disease
2) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940746 Disease Relevance 1.62 Pain Relevance 0
BACKGROUND/AIMS: To determine predictive values of fetal fibronectin and phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in cervicovaginal secretions and ultrasonographic measurement of cervical length for delivery <35 weeks in patients with uterine contractions.
Spec (determine) Regulation (values) of phosphorylated insulin-like growth factor binding protein-1 in uterine associated with dismenorea
3) Confidence 0.14 Published 2007 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 17339775 Disease Relevance 0.25 Pain Relevance 0.10
IGFBP-1, which is also derived from the liver, binds to free IGF-I and is negatively regulated by nutrition and insulin [20].
Regulation (regulated) of IGFBP-1 in liver
4) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.56 Pain Relevance 0.15
At baseline, IGFBP-I and IGFBP-III values were significantly higher in patients compared with healthy subjects at baseline (Table 2), whereas GHBP values in healthy subjects at baseline were almost double those in patients (P = 0·01).
Regulation (values) of IGFBP-I
5) Confidence 0.06 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0 Pain Relevance 0
To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH, and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human (h)GH.
Regulation (responses) of IGF binding protein
6) Confidence 0.05 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 1.17 Pain Relevance 0.54
Although plasma progesterone concentrations in humans have been well-documented, the cerebrospinal fluid (CSF) progesterone levels, which may also be important in this regard, have not been determined.
Regulation (important) of cerebrospinal fluid in plasma
7) Confidence 0.03 Published 1986 Journal Anesth. Analg. Section Abstract Doc Link 3740493 Disease Relevance 0 Pain Relevance 0.40
In this study we tested whether a similar approach, targeting concentrations in cerebrospinal fluid (CSF), could be used with epidural administration of the alpha 2-adrenergic analgesic clonidine.
Regulation (targeting) of cerebrospinal fluid in CSF associated with analgesic, epidural and clonidine
8) Confidence 0.01 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7605017 Disease Relevance 0 Pain Relevance 0.36
The function of and binding to receptors and enzymes may further be modulated by allosteric compounds [1-6].
Spec (may) Regulation (modulated) of binding
9) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.17
Furthermore, in order to look at the system with a reasonably high response, initially I choose parameter a, as the intrinsic efficacy on ligand binding at the orthosteric binding sites, to be well above unity, a >> 1, although, due to symmetry of the model, values for the intrinsic efficacy constants b and a may be interchanged without affecting the response curve, indicating that the concepts of the ligand as either primary ligand or modulator molecule can be switched freely.
Regulation (efficacy) of binding
10) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0

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