INT3835

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Context Info
Confidence 0.62
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.04
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 2
Notch 1
ScN 1
nerve 1
dorsal horn 1
su (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 16 100.00 Very High Very High Very High
Sciatic nerve 6 100.00 Very High Very High Very High
c fibre 2 99.76 Very High Very High Very High
tail-flick 18 99.60 Very High Very High Very High
Dorsal horn 1 99.40 Very High Very High Very High
Morphine 48 99.20 Very High Very High Very High
Pain 16 98.56 Very High Very High Very High
aspirin 4 95.92 Very High Very High Very High
Pain threshold 6 92.04 High High
nociceptor 2 89.68 High High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 12 99.56 Very High Very High Very High
Bradycardia 14 99.48 Very High Very High Very High
Pain 14 98.56 Very High Very High Very High
Nociception 8 92.44 High High
Aids-related Complex 3 81.52 Quite High
Urological Neuroanatomy 10 81.32 Quite High
INFLAMMATION 4 78.92 Quite High
Herpes Simplex Virus 1 62.60 Quite High
Disease 2 56.48 Quite High
Fibromyalgia 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The level of SU was increased among individuals with widespread pain (>5 locations) independent of underlying diagnoses compared to those with fewer pain sites (270.5 vs. 241.2 micromol/L).
Positive_regulation (increased) of SU
1) Confidence 0.62 Published 2006 Journal Scand. J. Rheumatol. Section Body Doc Link 16882588 Disease Relevance 0.07 Pain Relevance 0
BVB was largely inhibited by activation of A delta-fibers of the ScN or SU, but C-fiber contribution to BVB inhibition was also ascertained by means of selective C-fiber activation.
Positive_regulation (activation) of SU in ScN associated with c fibre, sciatic nerve and bradycardia
2) Confidence 0.39 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2802001 Disease Relevance 1.27 Pain Relevance 0.61
Besides known factors such as impaired renal function and obesity, widespread pain and sleep disturbances were related to an increase in SU.
Positive_regulation (increase) of SU
3) Confidence 0.36 Published 2006 Journal Scand. J. Rheumatol. Section Body Doc Link 16882588 Disease Relevance 0 Pain Relevance 0
The importance of long-term management of gout is the reduction and maintenance of SU in a goal range, usually defined as less than 6.0 mg/dL.
Positive_regulation (maintenance) of SU associated with crystal associated disease
4) Confidence 0.32 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19463070 Disease Relevance 0.94 Pain Relevance 0.21
The field potentials of TTX-r GS afferents had a maximum in laminae IV-VI of the dorsal horn, whereas the SFPs induced by SU stimulation were more evenly distributed over all laminae.
Positive_regulation (stimulation) of SU in dorsal horn associated with dorsal horn
5) Confidence 0.13 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17045398 Disease Relevance 0.20 Pain Relevance 0.13
Since (+)-morphine, (-)-morphine and (+)-naloxone do not have any affinity for the naloxone-inaccessible sigma receptors, we therefore propose that (+)-morphine and (-)-morphine attenuate the (-)-morphine-produced tail-flick inhibition via the activation of the naloxone-sensitive sigma receptor originally proposed by Tsao and Su [Tsao, L.T., Su, T.P., 1997.
Positive_regulation (activation) of Su in tail associated with tail-flick, narcan and morphine
6) Confidence 0.07 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17597599 Disease Relevance 0.23 Pain Relevance 2.17
Since (+)-morphine, (-)-morphine and (+)-naloxone do not have any affinity for the naloxone-inaccessible sigma receptors, we therefore propose that (+)-morphine and (-)-morphine attenuate the (-)-morphine-produced tail-flick inhibition via the activation of the naloxone-sensitive sigma receptor originally proposed by Tsao and Su [Tsao, L.T., Su, T.P., 1997.
Positive_regulation (activation) of Su in tail associated with tail-flick, narcan and morphine
7) Confidence 0.07 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17597599 Disease Relevance 0.23 Pain Relevance 2.16
The ratio RIII,Cu/RIII,Su was lowered to 10% with naphthalene and increased to 110% with lignocaine.
Positive_regulation (increased) of Su
8) Confidence 0.06 Published 1977 Journal Pain Section Abstract Doc Link 876670 Disease Relevance 0.66 Pain Relevance 0.71
These reflexes were used as an index of pain and were recorded in the biceps femoris muscle, elicited by electrical stimulation of the ipsilateral sural nerve (RIII,su) and of the skin in the distal receptive field of this nerve (RIII,Cu).
Positive_regulation (stimulation) of su in nerve associated with pain
9) Confidence 0.04 Published 1977 Journal Pain Section Abstract Doc Link 876670 Disease Relevance 0.38 Pain Relevance 0.22
Compared to wild-type embryos (Figure 5B), we found that the deltaC-positive area in the ventral ectoderm was 5.7-fold increased in mibta52b (Figure 5C; Table 1), 5.5-fold increased in destit446 (Figure 5D; Table 1) and 3.9-fold increased in X-Su(H)DBM mRNA-injected embryos (Figure 5E; Table 1), whose Notch activity was compromised due to a failure of deltaC ubiquitination, deltaC ligand expression, and transmission of the Notch signal through Su(H), respectively.
Positive_regulation (increased) of Su in Notch
10) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1810426 Disease Relevance 0.06 Pain Relevance 0

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