INT38366

Context Info Confidence 0.62 First Reported 1984 Last Reported 2010 Negated 23 Speculated 3 Reported most in Abstract Documents 45 Total Number 49 Disease Relevance 23.45 Pain Relevance 5.34

cytosol (Cat) mitochondrion (Cat) aging (Cat) Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)

Anatomy Link Frequency liver 4 stomach 3 plasma 2 lenses 2 kidney 2 Cat (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 69 100.00 cINOD 39 100.00 qutenza 2 99.58 Spinal cord 9 99.32 diclofenac 9 99.28 Paracetamol 7 98.88 Dorsal horn 1 97.96 ischemia 57 95.96 Sciatic nerve 2 93.80 Hyperalgesia 1 93.68

Disease Link Frequency Relevance Heat Diabetes Mellitus 660 100.00 Poisoning 118 100.00 INFLAMMATION 100 100.00 Injury 315 99.82 Stress 306 99.82 Apoptosis 69 98.96 Ulcers 84 98.72 Middle Cerebral Artery Infarction 19 98.64 Body Weight Changes 3 97.84 Body Weight 256 97.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Catalase activity did not change in these groups.

Neg (not) Regulation (change) of Catalase

1) Confidence 0.62 Published 2007 Journal Toxicol Ind Health Section Abstract Doc Link 18669169 Disease Relevance 0.17 Pain Relevance 0.07

We observed that l-histidine provoked an increase of chemiluminescence and a reduction of TRAP at concentrations of 2.5 mM and higher, while TBA-RS measurement, GSH-Px, CAT and SOD activities were not affected.

Neg (not) Regulation (affected) of CAT

2) Confidence 0.60 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15036381 Disease Relevance 0.33 Pain Relevance 0.14

Capsaicin pretreatment had no effect on CAT activity in any spinal cord region.

Neg (no) Regulation (effect) of CAT in spinal cord associated with qutenza and spinal cord

3) Confidence 0.60 Published 1986 Journal J. Neural Transm. Section Abstract Doc Link 3746289 Disease Relevance 0 Pain Relevance 0.46

The effects of superoxide dismutase, catalase, NaN3 and L-ascorbic acid on the generation of active oxygen from rat phagocytic cells were different between CL and LDH-NADH methods.

Regulation (effects) of catalase

4) Confidence 0.51 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6745813 Disease Relevance 0.17 Pain Relevance 0.36

In contrast, the activities of catalase, glutathione peroxidase and superoxide dismutase were not modified by proline acute treatment.

Neg (not) Regulation (modified) of catalase

5) Confidence 0.47 Published 2003 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 12615086 Disease Relevance 0.29 Pain Relevance 0.22

However, catalase and glutathione peroxidase activities were not affected by the presence of proline in the medium.

Neg (not) Regulation (affected) of catalase

6) Confidence 0.47 Published 2003 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 12615086 Disease Relevance 0.29 Pain Relevance 0.23

Kidney morphology and the levels of urea, creatinine and nitric oxide metabolites (NOx) in the plasma and the enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the level of malondialdehyde (MDA) in the kidney were determined.

Spec (determined) Regulation (determined) of CAT in kidney

7) Confidence 0.44 Published 2004 Journal Ren Fail Section Abstract Doc Link 15526905 Disease Relevance 0.37 Pain Relevance 0.13

Therefore, we decided to study the protective effect of taurine in ibuprofen-induced gastropathy and the effects of administration of taurine on the endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and reduced glutathione (GSH) of stomach.

Regulation (effects) of CAT in stomach

8) Confidence 0.44 Published 2004 Journal ScientificWorldJournal Section Abstract Doc Link 15632983 Disease Relevance 0.18 Pain Relevance 0.18

The antioxidant enzymes, catalase (CAT) and the reducing peptide glutathione (GSH), decreased in lenses of untreated diabetic rats 13 weeks after the STZ injection (Table 5; p<0.05, when compared with the control rats?

Regulation (control) of CAT in lenses associated with diabetes mellitus

9) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2600521 Disease Relevance 0.73 Pain Relevance 0.08

We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat.

Regulation (effect) of CAT

10) Confidence 0.44 Published 1995 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 7472901 Disease Relevance 0.41 Pain Relevance 0.28

However, the PKC inhibitors, chelerthyrine and G07874, abrogated ethanol's effect of CAT activity but did not alter isoproterenol's effects.

Regulation (effect) of CAT

11) Confidence 0.44 Published 2000 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 10923996 Disease Relevance 0 Pain Relevance 0

There was also a significant decrease in CAT levels in NAP PS group (P < 0.001), but no significant difference in cardiac tissue CAT levels was observed in TMZ PS group (P > 0.05) as compared to normal CTR group.

Neg (no) Regulation (difference) of CAT

12) Confidence 0.44 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0

The effect of coffee intake and exercise on catalase activities is shown in Table 4.

Regulation (effect) of catalase

13) Confidence 0.39 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.45 Pain Relevance 0

We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat.

Regulation (effect) of catalase

14) Confidence 0.37 Published 1995 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 7472901 Disease Relevance 0.41 Pain Relevance 0.28

Kidney morphology and the levels of urea, creatinine and nitric oxide metabolites (NOx) in the plasma and the enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the level of malondialdehyde (MDA) in the kidney were determined.

Spec (determined) Regulation (determined) of catalase in kidney

15) Confidence 0.37 Published 2004 Journal Ren Fail Section Abstract Doc Link 15526905 Disease Relevance 0.37 Pain Relevance 0.13

The antioxidant enzymes, catalase (CAT) and the reducing peptide glutathione (GSH), decreased in lenses of untreated diabetic rats 13 weeks after the STZ injection (Table 5; p<0.05, when compared with the control rats?

Regulation (control) of catalase in lenses associated with diabetes mellitus

16) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2600521 Disease Relevance 0.73 Pain Relevance 0.08

There was no significant effect on catalase levels in rats administered with natansnin alone.

Neg (no) Regulation (effect) of catalase

17) Confidence 0.34 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0 Pain Relevance 0

Similarly, erythrocyte catalase levels were diminished without a significant change in the liver catalase levels.

Neg (without) Regulation (change) of catalase in liver

18) Confidence 0.33 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.55 Pain Relevance 0.03

The same doses of TJ-10 administered to ANIT-untreated rats did not affect hepatic SOD, catalase, Se-GSHpx, and GSSG-R activities but the herbal medicine administered at a dose 2.6 g/kg BW caused a significant increase in hepatic G-6-PDH activity.

Neg (not) Regulation (affect) of catalase associated with body weight

19) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.90 Pain Relevance 0.06

The same doses of octacosanol given to rats without CCl4 intoxication had no effect on the hepatic SOD, catalase, and Se-GSHpx activities.

Neg (no) Regulation (effect) of catalase associated with poisoning

20) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 1.05 Pain Relevance 0.04

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