INT3837

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Context Info
Confidence 0.40
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.39
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
kidney 1
su (Mus musculus)
Pain Link Frequency Relevance Heat
algil 1 99.76 Very High Very High Very High
Pain threshold 3 96.88 Very High Very High Very High
aspirin 23 93.20 High High
Pain 4 86.72 High High
Inflammation 9 86.68 High High
cINOD 3 86.24 High High
corticosteroid 6 84.64 Quite High
Analgesic 2 78.80 Quite High
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 36 99.84 Very High Very High Very High
Pain 6 96.88 Very High Very High Very High
Disease 6 92.76 High High
INFLAMMATION 9 86.68 High High
Diuresis 1 86.36 High High
Nociception 2 75.00 Quite High
Apoptosis 3 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allopurinol and benzbromarone remain the cornerstone drugs for reducing SU levels lower than the saturation threshold to dissolve urate deposits effectively.
Negative_regulation (reducing) of SU
1) Confidence 0.40 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19463070 Disease Relevance 0.78 Pain Relevance 0.17
The importance of long-term management of gout is the reduction and maintenance of SU in a goal range, usually defined as less than 6.0 mg/dL.
Negative_regulation (reduction) of SU associated with crystal associated disease
2) Confidence 0.29 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19463070 Disease Relevance 0.95 Pain Relevance 0.21
When treating gout one needs to treat acute attacks, and lower excess stores of uric acid to achieve dissolution of monosodium urate crystals through a long-term reduction of SU concentrations far beyond the threshold for saturation of urate and provide prophylaxis to prevent acute flares.
Negative_regulation (reduction) of SU associated with crystal associated disease
3) Confidence 0.25 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19463070 Disease Relevance 0.95 Pain Relevance 0.25
Moreover, in a study of SA metabolism (to SU) using the isolated perfused rat kidney, the addition of the competitive substrate benzoic acid produced a rapid formation and excretion of hippuric acid with corresponding inhibition of SU formation and excretion (24).
Negative_regulation (inhibition) of SU in kidney
4) Confidence 0.13 Published 2008 Journal Journal of Agricultural and Food Chemistry Section Body Doc Link PMC2800778 Disease Relevance 0.09 Pain Relevance 0
In contrast, pethidine provoked a decrease in the RIII,Su threshold and an increase in RIII,Cu threshold, parallel with an increase in pain threshold sensation.
Negative_regulation (decrease) of Su associated with pain threshold and algil
5) Confidence 0.02 Published 1977 Journal Pain Section Abstract Doc Link 876670 Disease Relevance 0.63 Pain Relevance 0.73

General Comments

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