INT38373

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3b1) transport (Ap3b1) vesicle-mediated transport (Ap3b1)
Golgi apparatus (Ap3b1)
Anatomy Link Frequency
hippocampus 1
Ap3b1 (Mus musculus)
Ap3b1 - I362T (1)
Pain Link Frequency Relevance Heat
amygdala 6 99.72 Very High Very High Very High
Hippocampus 6 98.48 Very High Very High Very High
Enkephalin 8 82.96 Quite High
cva 9 80.48 Quite High
member 8 1 68.36 Quite High
Nucleus accumbens 2 64.80 Quite High
Bioavailability 8 23.76 Low Low
agonist 5 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Postmenopausal Osteoporosis 9 94.36 High High
Heart Disease 1 87.96 High High
Breast Cancer 20 86.80 High High
Frailty 14 86.20 High High
Deep Vein Thrombosis 7 83.20 Quite High
Osteoporosis 41 81.72 Quite High
Pulmonary Embolism 2 81.28 Quite High
Cramps 3 79.04 Quite High
Death 2 75.52 Quite High
Reprotox - General 1 6 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical stimulation of the amygdala causes early increases in the PE mRNA content in that structure and in the hippocampus.
Positive_regulation (increases) of PE mRNA in hippocampus associated with hippocampus and amygdala
1) Confidence 0.37 Published 1986 Journal J. Neurosci. Res. Section Abstract Doc Link 3746949 Disease Relevance 0 Pain Relevance 0.44
The dynamic state of the proenkephalin (PE) gene products during and after development of amygdaloid kindling was assayed by monitoring changes of the accumulation of PE mRNA and changes in proenkephalin-related peptides.
Positive_regulation (accumulation) of PE mRNA
2) Confidence 0.37 Published 1986 Journal J. Neurosci. Res. Section Abstract Doc Link 3746949 Disease Relevance 0 Pain Relevance 0.32
Some concerns on the overall risk/benefit profile of lasofoxifene are related to the slight increase in the number of deaths observed at five years in the PEARL study in subjects treated with lasofoxifene 0.25 mg/day versus placebo (90 vs 65, respectively).
Positive_regulation (increase) of PEARL
3) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.93 Pain Relevance 0.04
The I362T mutation results in an inactive channel, but the channel properties of TRPML3(I362T/A419P) are similar to those of TRPML3(A419P).
Positive_regulation (results) of I362T mutation (I362T)
4) Confidence 0.01 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17962195 Disease Relevance 0.08 Pain Relevance 0.07

General Comments

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