INT38384

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2005
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.58
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Por) oxidoreductase activity (Por) endoplasmic reticulum (Por)
enzyme binding (Por)
Anatomy Link Frequency
output neurons 1
nerve 1
Leydig cells 1
Por (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
c fibre 1 100.00 Very High Very High Very High
GABA receptor 1 99.76 Very High Very High Very High
nociceptor 3 98.88 Very High Very High Very High
gABA 6 95.36 Very High Very High Very High
Endogenous opioid 2 95.28 Very High Very High Very High
aspirin 6 87.92 High High
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Nociception 1 92.28 High High
Pain 1 84.16 Quite High
INFLAMMATION 1 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of ATP, especially at low concentration (10(-5) M or less), on C-fiber polymodal receptor (CPR) activity using a rat skin-nerve preparation in vitro.
Spec (examined) Regulation (effects) of CPR in nerve associated with c fibre
1) Confidence 0.47 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 15740803 Disease Relevance 0.18 Pain Relevance 0.53
Therefore, cupric ions, free or chelated, as well as their reduction to Cu+ by microsomes did not affect the activity of NADPH-dependent cytochrome P-450 reductase.
Neg (not) Regulation (affect) of cytochrome P-450 reductase
2) Confidence 0.46 Published 1986 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 3751624 Disease Relevance 0.07 Pain Relevance 0.27
It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
Neg (little) Regulation (effect) of P or in output neurons associated with gaba receptor, enkephalin and substance p
3) Confidence 0.44 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.02
NMB treatment antagonized the inhibitory effect of IMO on P450c17 and NADPH-P450 reductase activities.
Regulation (effect) of NADPH-P450 reductase
4) Confidence 0.41 Published 1998 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 9712411 Disease Relevance 0.14 Pain Relevance 0.28
The effect of acute stress and opioid antagonist on the activity of NADPH-P450 reductase in rat Leydig cells.
Regulation (effect) of NADPH-P450 reductase in Leydig cells associated with stress, antagonist and opioid
5) Confidence 0.24 Published 1998 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 9712411 Disease Relevance 0.20 Pain Relevance 0.29

General Comments

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