INT3840

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 8.90
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3B) plasma membrane (FCGR3B)
Anatomy Link Frequency
spinal 1
monocytes 1
NK cells 1
respiratory 1
FCGR3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 37 100.00 Very High Very High Very High
algil 2 99.76 Very High Very High Very High
Intractable pain 3 99.32 Very High Very High Very High
Pain threshold 6 98.92 Very High Very High Very High
depression 3 97.68 Very High Very High Very High
Analgesic 11 97.28 Very High Very High Very High
Migraine 6 96.64 Very High Very High Very High
headache 6 95.72 Very High Very High Very High
Inflammation 77 95.48 Very High Very High Very High
epidural 3 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 30 100.00 Very High Very High Very High
Intractable Pain 3 99.32 Very High Very High Very High
Pain 33 99.28 Very High Very High Very High
Heart Rate Under Development 2 98.32 Very High Very High Very High
Depression 7 98.28 Very High Very High Very High
Cancer 79 97.88 Very High Very High Very High
Systemic Lupus Erythematosus 34 97.68 Very High Very High Very High
Disease 24 97.64 Very High Very High Very High
Headache 9 96.64 Very High Very High Very High
Metastasis 2 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A progressive increase in heart rate and in respiratory frequency, as well as a facilitation in H reflex parallel to an inhibition of RIII reflex (threshold increased) were observed in all subjects as a function of repetition of stress during 45 min.
Negative_regulation (inhibition) of RIII in respiratory associated with stress and heart rate under development
1) Confidence 0.59 Published 1980 Journal Brain Res. Section Abstract Doc Link 7407606 Disease Relevance 0.61 Pain Relevance 0.33
In contrast, pethidine provoked a decrease in the RIII,Su threshold and an increase in RIII,Cu threshold, parallel with an increase in pain threshold sensation.
Negative_regulation (decrease) of RIII associated with pain threshold and algil
2) Confidence 0.57 Published 1977 Journal Pain Section Abstract Doc Link 876670 Disease Relevance 0.63 Pain Relevance 0.72
Flexion reflex RIII was depressed or suppressed by AN in 11 patients (52.4%), while no modification was observed in 9 cases and a paradoxical increase during AN was evidenced in 1 case.
Negative_regulation (suppressed) of RIII
3) Confidence 0.51 Published 1989 Journal Pain Section Abstract Doc Link 2594393 Disease Relevance 0.55 Pain Relevance 0.51
These depressive effects were maximal during the 2nd min of the conditioning period, showing an almost complete inhibition of the RIII reflex which gradually recovered its baseline value 6-9 min after the end of the conditioning period.
Negative_regulation (inhibition) of RIII associated with depression
4) Confidence 0.51 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2168836 Disease Relevance 0.25 Pain Relevance 0.25
In this study a reduction of RIII reflex threshold, strictly related to the severity of the disease, is described in migraine with interval headache (MIH), that is considered a severe and evolutive form of common migraine (CM).
Negative_regulation (reduction) of RIII associated with migraine, headache, migraine without aura and disease
5) Confidence 0.50 Published 1986 Journal Funct. Neurol. Section Abstract Doc Link 3609872 Disease Relevance 1.53 Pain Relevance 1.30
From a translational perspective, inhibition of the CD16- to CD16+ transition in circulating monocytes may have clinical applications for the treatment of metabolic and inflammatory bone disorders.


Negative_regulation (inhibition) of CD16 in monocytes associated with inflammation and bone cancer
6) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.08 Pain Relevance 0.44
CONCLUSIONS: Gastric distention produces volume-dependent inhibition of the somatic RIII reflex in humans.
Negative_regulation (inhibition) of RIII
7) Confidence 0.38 Published 1994 Journal Gastroenterology Section Body Doc Link 7926488 Disease Relevance 0 Pain Relevance 0
In all but 2 patients, RIII changes were rapidly reversible after AN interruption.
Negative_regulation (reversible) of RIII
8) Confidence 0.37 Published 1989 Journal Pain Section Abstract Doc Link 2594393 Disease Relevance 0.72 Pain Relevance 0.53
RIII depression was significantly associated with subjective pain relief, as assessed by conventional self-rating; moreover, in 2 patients it was possible to ameliorate the pain-suppressing effects of AN by selecting those stimulation parameters (intensity and frequency) that maximally depressed nociceptive reflex RIII.
Negative_regulation (depressed) of RIII associated with nociception, pain and depression
9) Confidence 0.37 Published 1989 Journal Pain Section Abstract Doc Link 2594393 Disease Relevance 0.79 Pain Relevance 0.56
BACKGROUND/AIMS: The spinal nociceptive RIII reflex, an exteroceptive cutaneous-muscular flexion reflex, is powerfully and specifically inhibited by painful heterotopic somatic stimuli.
Negative_regulation (inhibited) of RIII in spinal associated with nociception and pain
10) Confidence 0.37 Published 1994 Journal Gastroenterology Section Abstract Doc Link 7926488 Disease Relevance 0.17 Pain Relevance 0.19
These depressive effects were maximal during the second min of the conditioning period, showing a 80% inhibition of the RIII reflex which gradually recovered to its baseline value 7 min after the end of the conditioning period.
Negative_regulation (inhibition) of RIII associated with depression
11) Confidence 0.37 Published 1992 Journal Pain Section Abstract Doc Link 1738569 Disease Relevance 0.32 Pain Relevance 0.50
Cutaneous application of naphthalene provoked a decrease in the RIII,Cu threshold and relative pain threshold, whereas lignocaine increased them.
Negative_regulation (decrease) of RIII associated with pain threshold
12) Confidence 0.37 Published 1977 Journal Pain Section Abstract Doc Link 876670 Disease Relevance 0.57 Pain Relevance 0.51
The 30% reduction of basal MFI for CD16b from 1552 ± 188 in controls to 1092 ± 187 in feG-treated rats was maintained in OA-exposed animals, with MFI in these challenged rats being 1513 ± 158 in controls and 914 ± 134 in feG-treated rats.


Negative_regulation (reduction) of CD16b
13) Confidence 0.22 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.22 Pain Relevance 0.07
We also observed a significant decrease in CD16/Fc?
Negative_regulation (decrease) of CD16
14) Confidence 0.19 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0 Pain Relevance 0
Many mechanisms have been proposed for the functional inactivation of tumor associated NK cells including the over-expression of Fas ligand, the loss of mRNA for granzyme B [2] and decreased CD16 and its associated zeta chain [15].
Negative_regulation (decreased) of CD16 in NK cells associated with cancer
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.96 Pain Relevance 0.05
RESULTS: Non-noxious TENS1 stimulation applied segmentally produced inhibitions of the RIII reflex only during the 2-minute conditioning period.
Negative_regulation (inhibitions) of RIII
16) Confidence 0.10 Published 1998 Journal Arch Phys Med Rehabil Section Body Doc Link 9474003 Disease Relevance 0 Pain Relevance 0
There is a significant decrease of CD16 MFI (p?
Negative_regulation (decrease) of CD16
17) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.52 Pain Relevance 0
The administration of TENS2 heterotopically resulted in inhibitions of the RIII reflex both during and after the 2-minute conditioning period.
Negative_regulation (inhibitions) of RIII
18) Confidence 0.09 Published 1998 Journal Arch Phys Med Rehabil Section Body Doc Link 9474003 Disease Relevance 0 Pain Relevance 0

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