INT3841

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Context Info
Confidence 0.75
First Reported 1977
Last Reported 2011
Negated 4
Speculated 7
Reported most in Body
Documents 117
Total Number 124
Disease Relevance 58.99
Pain Relevance 28.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3B) plasma membrane (FCGR3B)
Anatomy Link Frequency
monocytes 25
lymphocytes 4
neutrophil 4
DCs 3
NK cells 3
FCGR3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1840 100.00 Very High Very High Very High
rheumatoid arthritis 849 100.00 Very High Very High Very High
depression 22 100.00 Very High Very High Very High
methotrexate 12 100.00 Very High Very High Very High
cytokine 1013 99.92 Very High Very High Very High
Arthritis 5383 99.84 Very High Very High Very High
Enkephalin 24 99.46 Very High Very High Very High
psoriasis 1282 99.40 Very High Very High Very High
Intractable pain 1 99.32 Very High Very High Very High
Opioid 15 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1471 100.00 Very High Very High Very High
Rheumatoid Arthritis 899 100.00 Very High Very High Very High
Depression 25 100.00 Very High Very High Very High
Seronegative Spondarthritis 4758 99.84 Very High Very High Very High
Psoriasis 1343 99.40 Very High Very High Very High
Hypercalcemia 370 99.36 Very High Very High Very High
Nociception 35 99.34 Very High Very High Very High
Intractable Pain 1 99.32 Very High Very High Very High
Disease 663 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 230 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Freshly isolated human monocytes are heterogeneous in regard to CD16 surface expression, and the majority of cells are CD16- (blue line in Figure 2(a)-a).
Gene_expression (expression) of CD16 in monocytes
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.20 Pain Relevance 0.08
Moreover, intermediate surface expression of CD16 noted in many Ps and PsA subjects may represent a transitional state in which monocytes are primed for osteoclastogenesis in response to environmental signals.
Gene_expression (expression) of CD16 in monocytes associated with psoriasis and arthritis
2) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.08 Pain Relevance 0.66
In contrast, the majority of CD14+ cells upregulated CD16 expression and became CD16+ in the absence of TNF?
Gene_expression (expression) of CD16
3) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.42 Pain Relevance 0.18
Finally, we showed a positive correlation between the level of CD16 cell surface expression and the extent of bone resorption.
Gene_expression (expression) of CD16 associated with hypercalcemia
4) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.13 Pain Relevance 0.57
It will be important to determine if the CD14+ cells with high CD16 expression are more likely to differentiate into OC compared with CD14+ cells with an intermediate level of CD16.
Gene_expression (expression) of CD16
5) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.41 Pain Relevance 0.26
We postulated that the surface expression of CD16 on monocytes might be essential for OC development but not for DC differentiation.
Gene_expression (expression) of CD16 in monocytes
6) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.40 Pain Relevance 0.22
We also examined the relation between CD16 expression, osteoclastogenesis potential and bone erosion activity.


Gene_expression (expression) of CD16
7) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.06 Pain Relevance 0.59
Collectively, these data (Figure 2(b)) suggest that monocytes undergo a transition stage with intermediate expression of CD16 before differentiating into OC, presumably following exposure to RANKL and M-CSF in the bone marrow, circulation, and the joint.
Gene_expression (expression) of CD16 in joint
8) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.00 Pain Relevance 0.54
To test this hypothesis, we compared the effect of RANKL + M-CSF with GM-CSF + IL-4 on CD16 surface expression.
Gene_expression (expression) of CD16
9) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.28 Pain Relevance 0.15
The cell surface expression of CD16 was monitored at two different time points after monocytes were purified from PBMC and cultured in plain, OC-promoting (RANKL + M-CSF), or DC-promoting (GM-CSF + IL-4) media (Figure 2(a)).
Gene_expression (expression) of CD16 in monocytes
10) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.28 Pain Relevance 0.15
, cells isolated from PsA patients had higher mean fluorescence intensities of CD16 expression than HC cells (compare CD16 expression on X-axis for CD14+CD16+ cells gated in rectangles, Figure 6(d) vs. 6(f)).


Gene_expression (expression) of CD16 associated with arthritis
11) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.49 Pain Relevance 0.20
Additional support for the plasticity of CD16 expression in these cells was the successful conversion of freshly sterile-sorted CD16- monocytes into CD16+ cells following overnight culture in media without exogenous cytokines (data not shown).
Gene_expression (expression) of CD16 in monocytes associated with cytokine
12) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.91 Pain Relevance 0.43
To this end, we examined the expression of the CD16 molecule in a cohort of HC, Ps, RA, and PsA patients.
Spec (examined) Gene_expression (expression) of CD16 associated with psoriasis, rheumatoid arthritis and arthritis
13) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.99 Pain Relevance 0.53
upregulation of CD16 cell surface expression on CD14+CD16+ cells was significantly greater in PsA patients than in HC.
Gene_expression (expression) of CD16 associated with arthritis
14) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.69 Pain Relevance 0.31
Collectively, our results suggest a model in which a subset of CD16- cells undergoes a transition to intermediate CD16 expression in response to inflammation, and subsequently differentiate into CD16+ cells prior to OC formation.
Gene_expression (expression) of CD16 associated with inflammation
15) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.88 Pain Relevance 0.36
on CD16 expression, human PBMC were cultured in either plain media or media supplemented with TNF?
Gene_expression (expression) of CD16
16) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0
We also demonstrated an expansion of circulating CD14+CD16+ monocytes in PsA subjects and identified cells that express intermediate levels of CD16.
Gene_expression (express) of CD16 in monocytes associated with arthritis
17) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.70 Pain Relevance 0.30
This model provides a mechanism to explain the regulation of OC formation and provides an explanation for the positive correlation between the CD16 surface expression and bone erosion activity shown in this study.
Gene_expression (expression) of CD16
18) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.11 Pain Relevance 0
CD16 surface expression is up-regulated by osteoclastogenic cytokines
Gene_expression (expression) of CD16 associated with cytokine
19) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.77 Pain Relevance 0.43
blocks CD16 expression in a particular monocyte subset, resulting in two distinct CD14+ populations (Figures 6(d) and 6(f), upper left and right panels).
Gene_expression (expression) of CD16 in monocyte
20) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.28 Pain Relevance 0.21

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