INT3842
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Stimulation-induced GSR was completely abolished in a dose-dependent manner by systemically (intravenously) administered atropine. | |||||||||||||||
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Following drug pretreatments, the activities of cytosolic superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR) were elevated 30-70%, 5-25% and 8-25%, respectively. | |||||||||||||||
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Activities of serum glutathione reductase, glutathione transferase and catalase and hepatic glutathione reductase in normal rats and serum glutathione peroxidase in hypercholesterolemic rats were enhanced by dietary spice principles. | |||||||||||||||
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Activities of serum glutathione reductase, glutathione transferase and catalase and hepatic glutathione reductase in normal rats and serum glutathione peroxidase in hypercholesterolemic rats were enhanced by dietary spice principles. | |||||||||||||||
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Hepatic glutathione reductase and glutathione peroxidase were significantly elevated by dietary spice principles in high-fat-fed animals. | |||||||||||||||
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Despite inhibiting cyclooxygenase activity, the attenuation of (S)-(+)-ketoprofen-induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity and glutathione levels but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa. | |||||||||||||||
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Significant decrease was also observed in the level of reduced glutathione (GSH), superoxide dismutase (SOD), glutathione-s-transferase and catalase activities for aspirin and nimesulide group while Celecoxib caused an increase in glutathione reductase (GR). | |||||||||||||||
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Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities as well as vitamins C and E, and glutathione levels were significantly (P<0.05) elevated by the extract. | |||||||||||||||
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In cisplatin-treated rats, the serum activities of aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase and alkaline phosphatase were significantly decreased, whereas the activities of isocitric dehydrogenase and glutathione reductase were increased. | |||||||||||||||
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Epoxide hydrolase, glutathione S-transferase, glutathione reductase, cytochrome P450 2B2, cytochrome P450 3A1, aldehyde dehydrogenase and UDP-glucuronosyltransferase were all induced by PB (table 3). | |||||||||||||||
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Silymarin, a flavonolignan obtained from Silybum marianum, comprises of silybin as the most active component that counteracts the leakage of alanine transaminase (ALT) and gamma glutamyl transferase and prevent lipid peroxidation (LPO).[2] The fruits of Terminalia chebula were used as common household remedy,[3] and its phenolics prevent nickel chloride-induced oxidative stress by decreasing LPO, restoring the activity of glutathione-S-transferase, glutathione reductase, and glutathione peroxidase.[4] The present investigation was carried out to study the hepato- and renoprotective effects of silymarin and T. chebula.
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Since glutathione functions as a cofactor of GPx [12], it appears plausible that the livers of BSO-treated rats showed a compensatory increase of glutathione reductase activity. | |||||||||||||||
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Subset analysis revealed that in unstable angina and acute myocardial infarction, superoxide anion, malonyldialdehyde and glutathione reductase were elevated while superoxide dismutase and catalase levels were reduced. | |||||||||||||||
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This investigation tested the hypothesis that aqueous extracts of T. polium maintains intracellular glutathione levels by augmenting glutathione peroxidase and glutathione reductase activity in cultured hepatocytes. | |||||||||||||||
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General Comments
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