INT38421

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.52
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zbtb7a) nucleus (Zbtb7a) intracellular (Zbtb7a)
DNA binding (Zbtb7a)
Anatomy Link Frequency
LRF 3
Zbtb7a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 23 100.00 Very High Very High Very High
tail-flick 10 93.76 High High
Dorsal horn neuron 2 90.16 High High
midbrain 11 86.12 High High
withdrawal 10 85.84 High High
Spinal cord 2 75.00 Quite High
Dorsal horn 2 65.12 Quite High
analgesia 3 53.44 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 23 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degree of suppression of unit responses increased with graded increases in PAG or LRF stimulation intensity.
Positive_regulation (increases) of LRF in LRF associated with central grey
1) Confidence 0.50 Published 1986 Journal Brain Res. Section Abstract Doc Link 3756519 Disease Relevance 0.68 Pain Relevance 0.53
The same animals were tested with the use of a tail flick paradigm modified to allow measurement of the force of tail movements in three orthogonal planes and thereby calculate the overall force vector of tail flicks elicited by graded noxious radiant heat pulses (38-58 degrees C, 5 s, 2-min intervals) delivered to the tail, again with and without concomitant PAG or LRF stimulation.
Neg (without) Positive_regulation (stimulation) of LRF in LRF associated with tail-flick and central grey
2) Confidence 0.42 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7666131 Disease Relevance 0.48 Pain Relevance 0.81
PAG stimulation significantly reduced the mean slope of the stimulus-response function (to 73%; n = 15), whereas LRF stimulation shifted it toward the right with a smaller slope reduction (to 85%) and 3 degrees C increase in threshold.
Positive_regulation (stimulation) of LRF in LRF associated with central grey
3) Confidence 0.42 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7666131 Disease Relevance 0.36 Pain Relevance 0.52

General Comments

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