INT38433

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Context Info
Confidence 0.06
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GRHPR) oxidoreductase activity (GRHPR) cellular nitrogen compound metabolic process (GRHPR)
cytoplasm (GRHPR)
Anatomy Link Frequency
liver 2
pancreatic islets 1
GRHPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 100.00 Very High Very High Very High
methadone 2 100.00 Very High Very High Very High
alcohol 1 97.40 Very High Very High Very High
tolerance 41 72.64 Quite High
Paracetamol 1 25.00 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Avian Sarcoma 1 84.64 Quite High
Respiratory Syncytial Virus 1 83.04 Quite High
Impaired Glucose Tolerance 43 73.28 Quite High
Obesity 35 71.20 Quite High
Insulin Resistance 25 56.12 Quite High
Reprotox - General 1 1 49.60 Quite Low
Polycystic Ovary Syndrome 5 44.72 Quite Low
Weight Loss 3 30.32 Quite Low
Diabetes Mellitus 15 13.00 Low Low
Thrombosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytochromes P-450 and b5, NADPH and NADH cytochrome c reductase, methadone and meperidine N-demethylase and morphine glucuronyltransferase activities were detected in microsomes from both maternal and fetal livers.
Gene_expression (detected) of reductase in livers associated with methadone and morphine
1) Confidence 0.06 Published 1986 Journal Dev Pharmacol Ther Section Abstract Doc Link 3757733 Disease Relevance 0 Pain Relevance 0.39
This cell line expressed cytochrome b5 (58 +/- 12 pmol/mg microsomal protein vs 528 +/- 80 pmol/mg in microsomal human liver) and a high level of NADPH: cytochrome P450 reductase (140 +/- 20 nmol.min-1.mg microsomal protein-1 vs 68 +/- 48 nmol.min-1.mg-1 in microsomal human liver).
Gene_expression (expressed) of reductase in liver
2) Confidence 0.03 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.17 Pain Relevance 0.05
However, this remains highly speculative, bearing in mind that evidence of A-ring reductase expression in human pancreatic islets is lacking.
Gene_expression (expression) of A-ring reductase in pancreatic islets
3) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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