INT38446

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Context Info
Confidence 0.64
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.28
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1) plasma membrane (Ryr1) cytoplasm (Ryr1)
Anatomy Link Frequency
foot 1
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 8 98.74 Very High Very High Very High
addiction 11 87.60 High High
Potency 3 75.36 Quite High
anesthesia 6 75.00 Quite High
tail-flick 1 72.08 Quite High
agonist 8 52.96 Quite High
antagonist 2 29.04 Quite Low
Adelta 1 25.00 Low Low
c fibre 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 3 79.68 Quite High
Tremor 1 58.88 Quite High
Malignant Hyperthermia 15 50.00 Quite Low
Contracture 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ryanodine (RyR) channels release Ca2+ into the cytosol when activated by Ca2+ influx through voltage-gated channels, or by cyclicADP ribose.
Localization (release) of RyR
1) Confidence 0.64 Published 2004 Journal Eur J Pain Section Abstract Doc Link 14987625 Disease Relevance 0 Pain Relevance 0.24
Because the inactivation of ECC leads to a cessation of SR Ca2+ release via RYR1, it seems reasonable to hypothesize that cytoplasmic domains of the DHPR, and the foot of RYR1, assume a different conformation than in the ECC-activated state (Fig. 6).
Localization (release) of RYR1 in foot
2) Confidence 0.63 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0.04
The protective effects of clonidine are likely to involve multiple effects, including blockade of acetylcholine release and postsynaptic muscarinic receptors and transient inhibition of acetylcholinesterase.
Localization (release) of acetylcholine release associated with clonidine
3) Confidence 0.03 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3761196 Disease Relevance 0.28 Pain Relevance 0.57

General Comments

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