INT3845

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Context Info
Confidence 0.76
First Reported 1977
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 79
Total Number 82
Disease Relevance 44.69
Pain Relevance 11.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
liver 2
erythrocytes 2
spinal cord 2
platelets 2
brain 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 91 99.84 Very High Very High Very High
cytokine 260 99.48 Very High Very High Very High
rheumatoid arthritis 411 99.36 Very High Very High Very High
Inflammation 889 99.30 Very High Very High Very High
Paracetamol 345 98.50 Very High Very High Very High
Angina 4 98.00 Very High Very High Very High
alcohol 4 97.44 Very High Very High Very High
Inflammatory mediators 61 96.60 Very High Very High Very High
aspirin 52 96.36 Very High Very High Very High
dexamethasone 31 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gingival Recession 7 100.00 Very High Very High Very High
Occupational Lung Diseases 196 99.98 Very High Very High Very High
Stress 1141 99.92 Very High Very High Very High
Targeted Disruption 38 99.82 Very High Very High Very High
Stroke 333 99.72 Very High Very High Very High
Rheumatoid Arthritis 411 99.36 Very High Very High Very High
INFLAMMATION 1009 99.30 Very High Very High Very High
Asthma 366 99.14 Very High Very High Very High
Sepsis 105 98.80 Very High Very High Very High
Repression 22 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of glutathione reductase and glutathione peroxidase of human platelets in unstable angina and myocardial infarction.
Gene_expression (Levels) of glutathione reductase in platelets associated with angina and myocardial infarction
1) Confidence 0.76 Published 1999 Journal Boll Chim Farm Section Title Doc Link 10622110 Disease Relevance 0.38 Pain Relevance 0.19
Levels of glutathione peroxidase and glutathione reductase were measured in the platelets of 30 patients, 10 of them affected by unstable angina, 10 of them reperfused after myocardial infarction and 10 matched healthy controls.
Gene_expression (Levels) of glutathione reductase in platelets associated with angina and myocardial infarction
2) Confidence 0.76 Published 1999 Journal Boll Chim Farm Section Abstract Doc Link 10622110 Disease Relevance 0.34 Pain Relevance 0.17
The presence of multiple GR monomers and dimers expressed in a cell-specific fashion at different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic.
Gene_expression (expressed) of GR
3) Confidence 0.74 Published 2007 Journal Stress Section Abstract Doc Link 17514590 Disease Relevance 1.05 Pain Relevance 0.18
The GC-independent repression of AP-1 and NF-kappa B activities was further demonstrated by overexpressing a ligand-binding deficient GR mutant.
Gene_expression (overexpressing) of GR associated with repression
4) Confidence 0.71 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.69 Pain Relevance 0.31
Since qualitative and quantitative defects of the GR have been reported in corticoresistant patients, the transfer of the GR gene in the lung epithelium, the primary site of inflammation in asthma, may restore sensitivity to GC in these patients.
Gene_expression (transfer) of GR gene in lung epithelium associated with asthma and inflammation
5) Confidence 0.71 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.66 Pain Relevance 0.28
After the mask, in experiment 2, GR was presented with a still screen picture asking her to report whether she had consciously seen the stimulus or not, pressing one of two buttons.
Gene_expression (presented) of GR
6) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507770 Disease Relevance 0 Pain Relevance 0
A post-mortem study of bipolar patients showed decreased expression of GR mRNA (Perlman et al 2004; Webster et al 2002) and an exaggerated responses to the dex/CRH test in healthy first degree relatives of mood disorder patients has been found (Lauer et al 1998).
Gene_expression (expression) of GR associated with affective disorder
7) Confidence 0.64 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.34 Pain Relevance 0
Using AP-1 and NF-kappa B-dependent reporter gene assays and an immunoassay for the pro-inflammatory cytokine RANTES, we show that the over-expressed GR significantly repressed AP-1 and NF-kappa B activities in the absence of hormone and that the GC dexamethasone produced an additive inhibitory effect.
Gene_expression (over-expressed) of GR associated with inflammation, dexamethasone and cytokine
8) Confidence 0.62 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.72 Pain Relevance 0.33
Assay of GR activity
Gene_expression (activity) of GR
9) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 0 Pain Relevance 0
A positive correlation between LOOH level and GPx and GR activities in endometrium was also recorded.
Gene_expression (activities) of GR in endometrium
10) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.22 Pain Relevance 0.17
As a prerequisite to in vivo studies, we have transfected A549 human lung epithelial cells with a GR expression vector.
Gene_expression (expression) of GR in epithelial cells
11) Confidence 0.55 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.72 Pain Relevance 0.32
The mean GR improved from 2.0?
Gene_expression (improved) of GR associated with gingival recession
12) Confidence 0.55 Published 2008 Journal Clin Oral Investig Section Body Doc Link PMC2491434 Disease Relevance 0.10 Pain Relevance 0
As expected, NQO1 and GSR activities and total GSH levels were significantly higher in cancer cells (Figure 5).
Gene_expression (activities) of GSR associated with cancer
13) Confidence 0.47 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.17 Pain Relevance 0
Predictably, the NQO1 and GSR enzyme activities and GSH levels were significantly higher in cancer cells.
Gene_expression (activities) of GSR enzyme associated with cancer
14) Confidence 0.47 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.99 Pain Relevance 0
The two populations in our study did not show a difference in mean baseline GSR levels before the aversive stimulus (see Results), suggesting (according to Mandryk and Inkpen) that our pre-aversive-stimulus baseline tasks (observation alone vs observation with imagery) were probably indistinguishable in terms of enjoyment.
Gene_expression (levels) of GSR associated with imagery
15) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2517650 Disease Relevance 0.12 Pain Relevance 0.18
Investigations into GR expression yielded heterogeneous findings.
Gene_expression (expression) of GR
16) Confidence 0.43 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 1.10 Pain Relevance 0.21
Although the mineralocorticoid receptor has a higher affinity for circulating glucocorticoids than the GR, the GR is expressed in much higher amounts in immune tissues [52].
Gene_expression (expressed) of GR
17) Confidence 0.43 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.41 Pain Relevance 0.25
We measured the transcript levels of NRF2, NQO1, GSR, GCLc, GCLm, MRP1, and MRP2 by real-time RT-PCR.
Gene_expression (levels) of GSR
18) Confidence 0.42 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.60 Pain Relevance 0
Figure 1 shows the averaged GSR for each group, expressed relative to baseline (see Methods).
Gene_expression (expressed) of GSR
19) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2517650 Disease Relevance 0.14 Pain Relevance 0.06
The hypothesis of GR compartmentalization may be supported by the fact that LPS and IL-1?
Gene_expression (compartmentalization) of GR
20) Confidence 0.37 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.75 Pain Relevance 0.20

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