INT38466

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Context Info
Confidence 0.29
First Reported 1986
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.36
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
spinal cord 4
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 47 100.00 Very High Very High Very High
cytokine 36 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
analgesia 9 99.60 Very High Very High Very High
Spinal cord 8 98.92 Very High Very High Very High
Kappa opioid receptor 3 98.92 Very High Very High Very High
antinociception 18 98.86 Very High Very High Very High
Delta opioid receptors 3 98.76 Very High Very High Very High
Analgesic 16 97.50 Very High Very High Very High
opioid receptor 32 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 95 99.68 Very High Very High Very High
Skin Diseases 4 97.76 Very High Very High Very High
INFLAMMATION 28 96.80 Very High Very High Very High
Bordatella Infection 1 92.04 High High
Dermatitis 18 89.12 High High
Opiate Addiction 2 82.76 Quite High
Nociception 31 82.32 Quite High
Pressure And Volume Under Development 12 81.52 Quite High
Drug Dependence 1 71.76 Quite High
Urological Neuroanatomy 1 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CPE-induced alterations in cytokine secretion
Positive_regulation (induced) of Localization (secretion) of CPE associated with cytokine
1) Confidence 0.29 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913569 Disease Relevance 0.29 Pain Relevance 0.19
CPE-induced contact irritation and sensitization
Positive_regulation (induced) of Localization (sensitization) of CPE
2) Confidence 0.29 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913569 Disease Relevance 0.25 Pain Relevance 0.08
The enhancement cannot be attributed to endogenous enkephalin release as the KO mice were shown to be deficient in enkephalin.
Positive_regulation (attributed) of Localization (release) of enkephalin associated with targeted disruption and enkephalin
3) Confidence 0.13 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.41 Pain Relevance 1.45
These results suggest that peripheral analgesic effects of kyotorphin are mediated through mechanisms of kyotorphin specific receptor and PTX-sensitive Gi/Go, and that the enkephalin release is not necessary for this analgesia.
Neg (not) Positive_regulation (necessary) of Localization (release) of enkephalin associated with analgesic, enkephalin and analgesia
4) Confidence 0.08 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9404952 Disease Relevance 0.17 Pain Relevance 1.13
The antinociception induced by beta-endorphin given intracerebroventricularly (i.c.v.) has been previously demonstrated to be mediated by the release of Met-enkephalin and subsequent stimulation of delta receptors in the spinal cord for antinociception.
Positive_regulation (stimulation) of Localization (release) of Met-enkephalin in spinal cord associated with antinociception, enkephalin and spinal cord
5) Confidence 0.06 Published 1993 Journal Life Sci. Section Abstract Doc Link 8387138 Disease Relevance 0 Pain Relevance 0.88
The antinociception induced by supraspinally administered beta-endorphin is mediated by the release of Met-enkephalin and subsequent stimulation of delta-opioid receptors from the spinal cord in mice.
Positive_regulation (mediated) of Localization (release) of Met-enkephalin in spinal cord associated with antinociception, delta opioid receptors, enkephalin and spinal cord
6) Confidence 0.05 Published 1994 Journal Life Sci. Section Abstract Doc Link 8041224 Disease Relevance 0 Pain Relevance 0.98
The antinociception induced by endomophin-2 contains additional components, which are mediated by the release of dynorphin A-(1-17) and [Met(5)]enkephalin which subsequently act on kappa-opioid receptors and delta(2)-opioid receptors to produce antinociception.
Positive_regulation (mediated) of Localization (release) of enkephalin associated with antinociception, dynorphin, kappa opioid receptor, opioid receptor and enkephalin
7) Confidence 0.04 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11567650 Disease Relevance 0 Pain Relevance 1.17
Moreover, the addition of D-Phe or its derivatives seemed to increase the per cent of recovered endogenous Met5-enkephalin released from veratridine-depolarized striatal particles.
Spec (seemed) Positive_regulation (increase) of Localization (released) of Met5-enkephalin associated with enkephalin
8) Confidence 0.03 Published 1986 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 3763485 Disease Relevance 0.23 Pain Relevance 1.31

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