INT38467

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Context Info
Confidence 0.33
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.42
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Dpa (Mus musculus)
Pain Link Frequency Relevance Heat
Acupuncture 266 100.00 Very High Very High Very High
Pain threshold 38 99.98 Very High Very High Very High
narcan 11 99.98 Very High Very High Very High
analgesia 96 98.84 Very High Very High Very High
Enkephalin 12 98.60 Very High Very High Very High
tolerance 2 97.48 Very High Very High Very High
Physical dependence 1 96.92 Very High Very High Very High
Morphine 4 96.00 Very High Very High Very High
Analgesic 29 90.96 High High
Dorsal horn 2 90.76 High High
Disease Link Frequency Relevance Heat
Pain 130 99.98 Very High Very High Very High
Drug Dependence 1 96.92 Very High Very High Very High
Stress 10 91.00 High High
Nociception 2 75.00 Quite High
Opiate Addiction 2 75.00 Quite High
Cancer 6 60.32 Quite High
Polyps 2 52.72 Quite High
Ganglion Cysts 2 8.16 Low Low
Neuralgia 22 5.00 Very Low Very Low Very Low
Reflex Sympathetic Dystrophy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although naloxone reduced the depressant action of DPA, this was associated with increases in spontaneous firing.
Negative_regulation (reduced) of DPA associated with narcan
1) Confidence 0.33 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6094212 Disease Relevance 0.15 Pain Relevance 0.58
The effect of D-Phenylalanine (D-Phe), putative carboxypeptidase A inhibitor and its four derivatives (T1-T4) on analgesia, development of tolerance and physical dependence to morphine, and on degradation of both exogenous and endogenous enkephalins was investigated.
Negative_regulation (inhibitor) of D-Phenylalanine associated with physical dependence, tolerance, enkephalin, morphine and analgesia
2) Confidence 0.21 Published 1986 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 3763485 Disease Relevance 0.24 Pain Relevance 1.00
DPA is thought to suppress the activity of carboxypeptidase, which decomposes endorphins.
Negative_regulation (suppress) of DPA
3) Confidence 0.08 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2396469 Disease Relevance 0.31 Pain Relevance 2.18
It was found that all four respondents whose rise in pain threshold persisted after DPA+LFEA, experienced a drop in PT after intravenous injections of naloxone.
Negative_regulation (persisted) of DPA+LFEA associated with pain threshold, narcan and acupuncture
4) Confidence 0.08 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2396469 Disease Relevance 0.72 Pain Relevance 2.19

General Comments

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