INT38479

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Context Info
Confidence 0.40
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.00
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcne2) lysosome (Kcne2)
Anatomy Link Frequency
coronary artery 1
muscle 1
brain 1
Kcne2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 2 99.10 Very High Very High Very High
Dopamine 5 99.02 Very High Very High Very High
beta blocker 1 97.40 Very High Very High Very High
anesthesia 3 91.52 High High
Catecholamine 3 80.40 Quite High
cocaine 1 70.96 Quite High
Thalamus 1 37.68 Quite Low
Sciatic nerve 12 21.28 Low Low
Bioavailability 1 18.84 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 4 99.84 Very High Very High Very High
Nerve Compression Syndromes 30 98.64 Very High Very High Very High
Myocardial Infarction 4 95.76 Very High Very High Very High
Cancer 5 95.36 Very High Very High Very High
Hypertension 7 94.92 High High
Acute Monocytic Leukemia 1 75.28 Quite High
Colon Cancer 1 71.04 Quite High
Hypersensitivity 1 55.32 Quite High
Injury 20 50.00 Quite Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The N-dealkylation of morphine based on product formed X mg protein-1 X 20 min-1 was significantly increased between animals kept at normoxic and at 1.2-ATA He-O2 conditions (17.6%, P less than 0.05) and between animals kept at normoxic and at 21 ATA He-O2 conditions (28.2%, P less than 0.05).
Positive_regulation (increased) of min-1 associated with morphine
1) Confidence 0.40 Published 1983 Journal Undersea Biomed Res Section Abstract Doc Link 6675228 Disease Relevance 0 Pain Relevance 0.22
During dopamine infusion (approximately 200 micrograms X kg-1 X min-1), overall CBF-to-GU ratio throughout the brain was elevated (P less than 0.0001) when compared with saline controls.
Positive_regulation (elevated) of min-1 in brain associated with dopamine
2) Confidence 0.08 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3766759 Disease Relevance 0.23 Pain Relevance 0.37
In contrast, 3 miRNAs (miR-499, miR-1, miR-133a, and miR-466b) were upregulated in the denervated muscle and 3 miRNAs (miR-329, miR-204, and miR-139-3p) were downregulated after 6 months.
Positive_regulation (upregulated) of miR-1 in muscle
3) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.24 Pain Relevance 0
Recent studies demonstrated the increase of miR-1 in coronary artery diseases (CAD) and miR-1 is downregulated by beta-blocker propranolol in rat model of myocardial infarction [29].
Positive_regulation (increase) of miR-1 in coronary artery associated with coronary artery disease, beta blocker and myocardial infarction
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.54 Pain Relevance 0.05

General Comments

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