INT385

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 182
Total Number 194
Disease Relevance 63.62
Pain Relevance 37.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
blood 13
myocytes 11
cardiac myocytes 9
heart 6
plasma 6
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 682 100.00 Very High Very High Very High
agonist 255 100.00 Very High Very High Very High
Neurotransmitter 192 100.00 Very High Very High Very High
Enkephalin 110 100.00 Very High Very High Very High
narcan 39 100.00 Very High Very High Very High
Inflammatory response 29 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
Intracerebroventricular 23 99.98 Very High Very High Very High
bradykinin 63 99.90 Very High Very High Very High
Neuropeptide 73 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 3082 100.00 Very High Very High Very High
Stress 656 100.00 Very High Very High Very High
INFLAMMATION 548 100.00 Very High Very High Very High
Cancer 253 100.00 Very High Very High Very High
Necrosis 35 100.00 Very High Very High Very High
Heart Rate Under Development 124 99.98 Very High Very High Very High
Pressure And Volume Under Development 76 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 106 99.96 Very High Very High Very High
Obesity 140 99.84 Very High Very High Very High
Coronary Heart Disease 85 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both angiotensin II and naloxone also produced significant decreases in core temperatures that were not altered by restraint.
Gene_expression (produced) of angiotensin II associated with narcan
1) Confidence 0.78 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8951958 Disease Relevance 0.15 Pain Relevance 0.36
[Accelerated angiotensinogen gene expression in the rat brain made tolerant to morphine or electroacupuncture stimulation].
Gene_expression (expression) of angiotensinogen gene in brain associated with electroacupuncture and morphine
2) Confidence 0.78 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.73
Using this assay, baseline levels of Ang IV in dialysates from different brain structures were undetectable.
Gene_expression (levels) of Ang IV in brain structures
3) Confidence 0.78 Published 2007 Journal J Sep Sci Section Abstract Doc Link 17688302 Disease Relevance 0 Pain Relevance 0.06
These data may indicate that Ang IV is mainly present intracellularly.
Gene_expression (present) of Ang IV
4) Confidence 0.78 Published 2007 Journal J Sep Sci Section Abstract Doc Link 17688302 Disease Relevance 0 Pain Relevance 0.09
AngII, 7-nitroindazole (7NI)-nNOS blocker, or both were centrally administered (5 mul, bolus) under light chloroform anesthesia prior to each experimental paradigms: (1) In vivo: measurements of skin-vasodilatation (VTsh) and salivation-cooling (STsh) thresholds, and heat endurance in conscious heat/hypohydrated stressed rats; (2) expression of AT(1) and AT(2) AngII receptors and nNOS were measured in the hypothalamus (Western blot); (3) transcript levels of the coding genes were measured using real-time PCR.
Gene_expression (expression) of AngII in hypothalamus associated with anesthesia and increased venous pressure under development
5) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519680 Disease Relevance 0.52 Pain Relevance 0.10
A supposition is made about the increase of angiotensin II brain synthesis under conditions of emotional stress.
Gene_expression (synthesis) of angiotensin II in brain associated with stress
6) Confidence 0.77 Published 1985 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 4040686 Disease Relevance 0.35 Pain Relevance 0.21
We used three experimental paradigms: (1) heat defense responses [salivation (STsh), vasodilatation (VTsh) temperature thresholds and heat-endurance] in conscious, heat-stressed (39 degrees C) rats; (2) Western immunoblotting to detect AngII AT(1) and AT(2) receptors and nNOS protein expression; (3) real-time PCR to measure gene transcripts.
Gene_expression (expression) of AngII associated with increased venous pressure under development
7) Confidence 0.77 Published 2004 Journal Brain Res. Section Abstract Doc Link 15051521 Disease Relevance 0.32 Pain Relevance 0.17
These findings confirm that both angiotensin II and angiotensin-(1-7) express biological activity through receptor-mediated actions in the dorsal medulla oblongata.
Gene_expression (express) of angiotensin in medulla oblongata associated with medulla
8) Confidence 0.77 Published 1990 Journal Hypertension Section Abstract Doc Link 2298474 Disease Relevance 0.14 Pain Relevance 0.17
The expression of angiotensinogen protein in neonatal cultured cardiac myocytes was assessed by immunoblot.
Gene_expression (expression) of angiotensinogen protein in cardiac myocytes
9) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.18 Pain Relevance 0
Although, the absence of the ACE2 inhibitor did not change the 125I-Ang-(1–12) level in the medium of the SHR myocytes, removal of the chymostatin inhibitor increased production of Ang I (20%) and Ang II (21%). 125I-Ang-(1–12) metabolism by SHR myocytes was significantly increased in the absence of chymostatin.
Gene_expression (production) of Ang II in myocytes associated with hypertension
10) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.64 Pain Relevance 0
Angiotensin-(1–12) [Ang-(1–12)] functions as an endogenous substrate for the productions of Ang II and Ang-(1–7) by a non-renin dependent mechanism.
Gene_expression (productions) of Ang II
11) Confidence 0.77 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3018413 Disease Relevance 0.06 Pain Relevance 0
Angiotensinogen protein expression in the neonatal WKY and SHR cardiac myocytes maintained in serum-free medium for 48 hours was determined by Western blot analysis using appropriate antibodies.
Gene_expression (expression) of Angiotensinogen protein in cardiac myocytes associated with hypertension
12) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.62 Pain Relevance 0
Although, the absence of the ACE2 inhibitor did not change the 125I-Ang-(1–12) level in the medium of the SHR myocytes, removal of the chymostatin inhibitor increased production of Ang I (20%) and Ang II (21%). 125I-Ang-(1–12) metabolism by SHR myocytes was significantly increased in the absence of chymostatin.
Gene_expression (production) of Ang I in myocytes associated with hypertension
13) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.63 Pain Relevance 0
After correcting the angiotensinogen protein expression level with loading control (EF-1?)
Gene_expression (expression) of angiotensinogen protein
14) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.62 Pain Relevance 0
The heart is an organ where local formation of Ang II is implicated to regulate cardiac remodeling due to increased afterload or ischemia. [16], [17] Central to this concept is the demonstration that Ang II can be produced locally and function as a paracrine [16], [17] or autocrine factor. [18] Through the use of radiolabeled 125I-Ang I and 125I-Ang II van Kats et al. [19] concluded that most of the Ang I and Ang II found in the heart was produced locally.
Gene_expression (produced) of Ang II in heart associated with ischemia
15) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.49 Pain Relevance 0.05
Before collecting the myocytes for angiotensinogen protein expression, the cells were cultured for 48 hours in serum-deprived medium.
Gene_expression (expression) of angiotensinogen protein in myocytes
16) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.22 Pain Relevance 0
The angiotensinogen protein (60 KD band size) was present in both WKY and SHR myocytes (Figure 6).
Gene_expression (present) of angiotensinogen protein in myocytes associated with hypertension
17) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.62 Pain Relevance 0
In the controlled environment of a cell culture system, neonatal cardiac myocytes of SHR and WKY metabolized 125I-Ang-(1–12) into Ang I, leading to sequential production of Ang II, Ang-(1–7), and other smaller angiotensin fragments.
Gene_expression (production) of Ang II in cardiac myocytes associated with hypertension
18) Confidence 0.77 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.41 Pain Relevance 0
Angiotensin IV, a hexapeptide fragment (3-8) of angiotensin II metabolism, has been reported to produce vasodilatation within the renal vasculature by activation of the putative AT4 receptor.
Gene_expression (produce) of Angiotensin IV in vasculature associated with increased venous pressure under development
19) Confidence 0.76 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10445671 Disease Relevance 0.10 Pain Relevance 0
Although the synthesis and distribution of the putative neurotransmitter angiotensin (ANG) has been well established, little is known about the mechanism for its release.
Gene_expression (synthesis) of angiotensin associated with neurotransmitter
20) Confidence 0.76 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.05

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