INT38504

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
tail 2
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 14 100.00 Very High Very High Very High
narcan 3 99.92 Very High Very High Very High
Morphine 11 99.84 Very High Very High Very High
tolerance 10 99.48 Very High Very High Very High
Opioid 1 98.56 Very High Very High Very High
tail-flick 2 96.60 Very High Very High Very High
Analgesic 2 87.32 High High
antinociception 6 83.12 Quite High
antagonist 3 79.44 Quite High
Antinociceptive 4 77.68 Quite High
Disease Link Frequency Relevance Heat
Syndrome 2 86.08 High High
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several differences between CCK-8-S and opioid substances included the need for relatively large doses of naloxone to block the effects of CCK-8-S in the phenylquinone-induced writhing test and the lack of effect of CCK-8-S in the tail-flick test.
Negative_regulation (block) of Regulation (effects) of CCK-8-S in tail associated with tail-flick, narcan and opioid
1) Confidence 0.42 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3774112 Disease Relevance 0.17 Pain Relevance 0.65
Low doses of L-365, 260 diminished the effect of cholecystokinin-8 on morphine tolerance.
Negative_regulation (diminished) of Regulation (effect) of cholecystokinin-8 associated with tolerance, cholecystokinin and morphine
2) Confidence 0.41 Published 1999 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9974190 Disease Relevance 0 Pain Relevance 2.24

General Comments

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