INT3851

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1977
Last Reported 2011
Negated 0
Speculated 3
Reported most in Abstract
Documents 58
Total Number 61
Disease Relevance 29.15
Pain Relevance 10.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 12
plasma 4
blood 2
hepatocyte 1
bile 1
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 52 100.00 Very High Very High Very High
cytokine 10 100.00 Very High Very High Very High
Paracetamol 186 99.64 Very High Very High Very High
ischemia 30 99.12 Very High Very High Very High
Pain 7 97.44 Very High Very High Very High
fibrosis 29 96.24 Very High Very High Very High
anesthesia 18 93.40 High High
Gabapentin 2 93.08 High High
addiction 2 93.00 High High
Inflammatory response 14 92.44 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 147 100.00 Very High Very High Very High
Urological Neuroanatomy 9 100.00 Very High Very High Very High
Disease 58 99.64 Very High Very High Very High
Inflammatory Bowel Disease 11 99.28 Very High Very High Very High
Congenital Anomalies 8 99.28 Very High Very High Very High
Cirrhosis 40 99.20 Very High Very High Very High
Cv Unclassified Under Development 33 99.12 Very High Very High Very High
Death 25 99.08 Very High Very High Very High
Burns 4 99.00 Very High Very High Very High
Coagulation Disorder 1 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, treatment with AAP + PYP produced levels of caspase-3 activity, DNA fragmentation, GSH and GOT/GPT that matched the values seen in the control group.
Gene_expression (produced) of GOT
1) Confidence 0.65 Published 2008 Journal Phytother Res Section Abstract Doc Link 18729249 Disease Relevance 0.41 Pain Relevance 0.07
Acetaminophen-induced liver function abnormalities were characterized by elevation of transaminase levels with ALT higher than AST(6/6), coagulopathy(5/6), thrombocytopenia (1/6), but absence of jaundice(6/6).
Gene_expression (levels) of transaminase in liver associated with coagulation disorder, paracetamol, congenital anomalies, thrombocytopenia and jaundice
2) Confidence 0.62 Published 1997 Journal Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Section Abstract Doc Link 9473817 Disease Relevance 0.96 Pain Relevance 0.47
The quantity of acetaminophen ingested varied from 5 to 50 g and 19 patients developed raised transaminase levels in the serum during the initial period.
Gene_expression (levels) of transaminase associated with paracetamol
3) Confidence 0.56 Published 1977 Journal Am J Dig Dis Section Abstract Doc Link 879126 Disease Relevance 0.40 Pain Relevance 0.40
Moreover, a significant correlation was found between the ranitidine dose and the survival rate, as evidenced by transaminase levels in the serum and histology of the liver.
Gene_expression (levels) of transaminase in liver
4) Confidence 0.56 Published 1990 Journal Dig. Dis. Sci. Section Abstract Doc Link 2307085 Disease Relevance 0.31 Pain Relevance 0.49
The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) raised serum ALP, GOT and GPT levels to 328 +/- 30, 493 +/- 102 and 357 +/- 109 IU/l (n = 10) respectively, compared to respective control values of 177 +/- 21, 106 +/- 15 and 47 +/- 12. 6.
Gene_expression (raised) of GOT
5) Confidence 0.52 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.23 Pain Relevance 0.37
Gradual weight loss, control of blood glucose levels, and use of medications (e.g., pioglitazone, metformin) may normalize hepatic transaminase levels, but the clinical benefit of aggressively treating nonalcoholic fatty liver disease is unknown.
Gene_expression (levels) of transaminase in liver associated with fatty liver and weight loss
6) Confidence 0.49 Published 2008 Journal Am Fam Physician Section Abstract Doc Link 18619079 Disease Relevance 1.83 Pain Relevance 0.17
METHODS: Questionnaires mailed to the medical directors of 76 poison centres in North America and 48 poison centres in Europe asked respondents to comment on the management of a hypothetical case of a child who had received repeated doses of paracetamol at a daily dose of 90 mg/kg during a febrile illness and who presented to the emergency department with mildly elevated serum transaminase levels.
Gene_expression (levels) of transaminase
7) Confidence 0.49 Published 2002 Journal Drug Saf Section Body Doc Link 12113645 Disease Relevance 0.07 Pain Relevance 0
Acetaminophen at a dose of 640 mg/kg produced liver damage in rats as manifested by the rise in serum levels of alkaline phosphatase (ALP), glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) to 430 +/- 68, 867 +/- 305 and 732 +/- 212 IU/l (n = 10) respectively, compared to respective control values of 202 +/- 36, 59 +/- 14 and 38 +/- 7. 4.
Gene_expression (produced) of GOT in liver associated with glutamate, paracetamol and hepatotoxicity
8) Confidence 0.47 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.27 Pain Relevance 0.46
The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP).
Gene_expression (levels) of transaminase
9) Confidence 0.44 Published 2000 Journal Phytother Res Section Abstract Doc Link 10960902 Disease Relevance 0.17 Pain Relevance 0.17
KEY FINDINGS: Levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatases, which were increased in the serum, were found to be significantly reduced by the treatment of lutein in a dose-dependent manner, indicating that lutein may reduce the hepatotoxicity induced by these agents(. )Serum bilirubin was also significantly lower in lutein-treated groups compared with control.
Gene_expression (glutamate) of transaminase
10) Confidence 0.40 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663040 Disease Relevance 0 Pain Relevance 0
KEY FINDINGS: Levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatases, which were increased in the serum, were found to be significantly reduced by the treatment of lutein in a dose-dependent manner, indicating that lutein may reduce the hepatotoxicity induced by these agents(. )Serum bilirubin was also significantly lower in lutein-treated groups compared with control.
Gene_expression (glutamate) of transaminase
11) Confidence 0.40 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663040 Disease Relevance 0 Pain Relevance 0
Animals fed corn oil and/or low protein levels showed significant increases in both GOT and GPT levels (Fig. 1).
Gene_expression (levels) of GOT
12) Confidence 0.40 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.56 Pain Relevance 0.39
Animals fed PUFA and/or low protein diet had significantly elevated plasma GPT and GOT levels and decreased GSH levels after acetaminophen challenge.
Gene_expression (levels) of GOT in plasma associated with paracetamol
13) Confidence 0.40 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.28 Pain Relevance 0.26
Plasma GOT and GPT levels increased significantly after acute intoxication with acetaminophen.
Gene_expression (levels) of GOT in Plasma associated with paracetamol and poisoning
14) Confidence 0.40 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.52 Pain Relevance 0.23
The liver damage was evidenced by elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD).
Gene_expression (levels) of serum glutamate oxaloacetate transaminase in liver associated with glutamate and hepatotoxicity
15) Confidence 0.38 Published 2003 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 15266956 Disease Relevance 0.28 Pain Relevance 0.29
Overlap in proteomic coverage was limited (Figure 4A), with no commonality between DIGE and Luminex, and only one species (Got1) detected by both iTRAQ and Luminex.
Gene_expression (detected) of Got1
16) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.18 Pain Relevance 0
Their effect on the body and organs weight and certain biochemical profiles including total serum protein, cholesterol, triglycerides, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum testosterone, and FSH levels were also measured.
Gene_expression (levels) of serum glutamic oxaloacetic transaminase in body
17) Confidence 0.35 Published 2004 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 15349082 Disease Relevance 0 Pain Relevance 0.25
Acetaminophen at a dose of 640 mg/kg produced liver damage in rats as manifested by the rise in serum levels of GOT and GPT to 1528 +/- 310 and 904 +/- 261 IU/l (n = 10) respectively, compared to respective control values of 80 +/- 11 and 38 +/- 09. 4.
Gene_expression (levels) of GOT in liver associated with paracetamol and hepatotoxicity
18) Confidence 0.34 Published 1993 Journal Gen. Pharmacol. Section Abstract Doc Link 8112519 Disease Relevance 0.27 Pain Relevance 0.35
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC).
Gene_expression (levels) of serum glutamate oxaloacetate transaminase associated with paracetamol and glutamate
19) Confidence 0.28 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15875720 Disease Relevance 0 Pain Relevance 0.35
Oxytocin treatment significantly reversed the I/R-induced elevations in serum transaminase and TNF-alpha levels and in hepatic MPO and collagen levels, and reduced the hepatic damage scores.
Gene_expression (levels) of serum transaminase associated with urological neuroanatomy
20) Confidence 0.25 Published 2008 Journal Peptides Section Abstract Doc Link 18403049 Disease Relevance 1.20 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox